Assignee
CHUGAI PHARMACEUTICAL CO LTD
JP·746 granted patents·492 pending applications·11,047 citations·filing 1974–2025
Top patents by PatentIndex Score
1,238 records- 0198US12122840B2Method of modifying isoelectric point of antibody via amino acid substitution in CDRCHUGAI PHARMACEUTICAL CO LTD·Filed 2024·Granted Oct 22, 2024·5 cites·24 claims
- 0298US12116414B2Method of modifying isoelectric point of antibody via amino acid substitution in CDRCHUGAI PHARMACEUTICAL CO LTD·Filed 2024·Granted Oct 15, 2024·5 cites·21 claims
- 0398US11168344B2Methods for producing polypeptides by regulating polypeptide associationCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted Nov 9, 2021·18 cites·39 claims
- 0498US10934344B2Methods of modifying antibodies for purification of bispecific antibodiesCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted Mar 2, 2021·19 cites·30 claims
- 0598US10253091B2Antibody constant region variantCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Apr 9, 2019·27 cites·35 claims
- 0698US9828429B2Method of modifying isoelectric point of antibody via amino acid substitution in CDRCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Nov 28, 2017·40 cites·80 claims
- 0798US7479543B2Reshaped human antibody to human interleukin-6 receptorCHUGAI PHARMACEUTICAL CO LTD·Filed 2004·Granted Jan 20, 2009·239 cites·1 claims
- 0898US5795965AReshaped human to human interleukin-6 receptorCHUGAI PHARMACEUTICAL CO LTD·Filed 1992·Granted Aug 18, 1998·368 cites·6 claims
- 0997US11371039B2Antigen-binding molecule capable of binding to two or more antigen molecules repeatedlyCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Jun 28, 2022·4 cites·30 claims
- 1097US11359194B2Antigen-binding molecule capable of binding two or more antigen molecules repeatedlyCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Jun 14, 2022·4 cites·29 claims
- 1197US11332533B2Modified antibody constant regionCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted May 17, 2022·13 cites·21 claims
- 1297US11248053B2Method of modifying isoelectric point of antibody via amino acid substitution in CDRCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted Feb 15, 2022·16 cites·28 claims
- 1397US11142587B2Method for producing polypeptide hetero-oligomerCHUGAI PHARMACEUTICAL CO LTD·Filed 2016·Granted Oct 12, 2021·13 cites·14 claims
- 1497US10472623B2Antigen-binding molecule capable of binding two or more antigen molecules repeatedlyCHUGAI PHARMACEUTICAL CO LTD·Filed 2018·Granted Nov 12, 2019·29 cites·21 claims
- 1597US10066018B2Antibody constant region variantCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Sep 4, 2018·28 cites·47 claims
- 1697US9890377B2Antigen-binding molecule capable of binding to two or more antigen molecules repeatedlyCHUGAI PHARMACEUTICAL CO LTD·Filed 2013·Granted Feb 13, 2018·34 cites·24 claims
- 1797US9765135B2Anti-C5 antibodiesCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Sep 19, 2017·51 cites·66 claims
- 1897US7750126B2Antibodies that bind to a member of the IL-6/G-CSF/MGF familyCHUGAI PHARMACEUTICAL CO LTD·Filed 2007·Granted Jul 6, 2010·22 cites·10 claims
- 1997US7521052B2Methods for treating interleukin-6 related diseasesCHUGAI PHARMACEUTICAL CO LTD·Filed 2004·Granted Apr 21, 2009·92 cites·1 claims
- 2097US7320792B2Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonistCHUGAI PHARMACEUTICAL CO LTD·Filed 2001·Granted Jan 22, 2008·147 cites·3 claims
- 2197US6610285B1Cytokine-like proteins that promote cell proliferationCHUGAI PHARMACEUTICAL CO LTD·Filed 2000·Granted Aug 26, 2003·87 cites·10 claims
- 2297US5817790AReshaped human antibody to human interleukin-6 receptorCHUGAI PHARMACEUTICAL CO LTD·Filed 1995·Granted Oct 6, 1998·233 cites·6 claims
- 2396US11787836B2Method for synthesizing peptide containing N-substituted amino acidCHUGAI PHARMACEUTICAL CO LTD·Filed 2022·Granted Oct 17, 2023·12 cites·12 claims
- 2496US11718678B2Method for altering plasma retention and immunogenicity of antigen-binding moleculeCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Aug 8, 2023·7 cites·16 claims
- 2596US11454633B2Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of useCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Sep 27, 2022·4 cites·19 claims
- 2696US10858356B2Pyrazolopyridine derivative having GLP-1 receptor agonist effectCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted Dec 8, 2020·18 cites·17 claims
- 2796US10738111B2Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of useCHUGAI PHARMACEUTICAL CO LTD·Filed 2018·Granted Aug 11, 2020·17 cites·25 claims
- 2896US10662245B2Methods of reducing IL-6 activity for disease treatmentCHUGAI PHARMACEUTICAL CO LTD·Filed 2014·Granted May 26, 2020·22 cites·25 claims
- 2996US10253100B2Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearanceCHUGAI PHARMACEUTICAL CO LTD·Filed 2012·Granted Apr 9, 2019·37 cites·36 claims
- 3096US10000560B2Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of useCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Jun 19, 2018·26 cites·43 claims
- 3196US9868948B2Antigen-binding molecule capable of binding to two or more antigen molecules repeatedlyCHUGAI PHARMACEUTICAL CO LTD·Filed 2013·Granted Jan 16, 2018·27 cites·34 claims
- 3296US7919086B2Anti-glypican 3 antibodyCHUGAI PHARMACEUTICAL CO LTD·Filed 2005·Granted Apr 5, 2011·74 cites·56 claims
- 3396US7897792B2Coumarin derivative having antitumor activityCHUGAI PHARMACEUTICAL CO LTD·Filed 2007·Granted Mar 1, 2011·259 cites·13 claims
- 3496US7279558B2Genes associated with the maintenance of differentiation of smooth muscle cellsCHUGAI PHARMACEUTICAL CO LTD·Filed 2005·Granted Oct 9, 2007·37 cites·8 claims
- 3596US7052873B2Natural human antibodyCHUGAI PHARMACEUTICAL CO LTD·Filed 1998·Granted May 30, 2006·151 cites·8 claims
- 3696US6723319B1Method of treating inflammatory intestinal diseases containing as the ingredient IL-6 receptors antibodiesCHUGAI PHARMACEUTICAL CO LTD·Filed 1999·Granted Apr 20, 2004·240 cites·4 claims
- 3796US4666634Avitamin D3 derivatives having a substituent at 2-positionCHUGAI PHARMACEUTICAL CO LTD·Filed 1985·Granted May 19, 1987·185 cites·10 claims
- 3896US4200640ANitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical useCHUGAI PHARMACEUTICAL CO LTD·Filed 1978·Granted Apr 29, 1980·47 cites·17 claims
- 3995US11891457B2Peptide-compound cyclization methodCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Feb 6, 2024·12 cites·14 claims
- 4095US11814381B2Pyrazolopyridine derivative having GLP-1 receptor agonist effectCHUGAI PHARMACEUTICAL CO LTD·Filed 2020·Granted Nov 14, 2023·3 cites·1 claims
- 4195US11767363B2High concentration antibody-containing liquid formulationCHUGAI PHARMACEUTICAL CO LTD·Filed 2023·Granted Sep 26, 2023·2 cites·6 claims
- 4295US11584798B2High concentration antibody-containing liquid formulationCHUGAI PHARMACEUTICAL CO LTD·Filed 2022·Granted Feb 21, 2023·2 cites·6 claims
- 4395US11274151B2CD3-targeting and DLL3-targeting multispecific antigen-binding molecules and uses thereofCHUGAI PHARMACEUTICAL CO LTD·Filed 2021·Granted Mar 15, 2022·11 cites·28 claims
- 4495US11154615B2Library of antigen-binding molecules including modified antibody variable regionCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Oct 26, 2021·8 cites·11 claims
- 4595US11111311B2Anti-DLL3 antibodyCHUGAI PHARMACEUTICAL CO LTD·Filed 2015·Granted Sep 7, 2021·9 cites·17 claims
- 4695US10744201B2Method for treating rheumatoid arthritis with a human IL-6 receptor antibody and methotrexateCHUGAI PHARMACEUTICAL CO LTD·Filed 2018·Granted Aug 18, 2020·6 cites·15 claims
- 4795US10450381B2Methods of treatment that include the administration of bispecific antibodiesCHUGAI PHARMACEUTICAL CO LTD·Filed 2016·Granted Oct 22, 2019·28 cites·84 claims
- 4895US9975966B2Cytotoxicity-inducing theraputic agentCHUGAI PHARMACEUTICAL CO LTD·Filed 2017·Granted May 22, 2018·25 cites·10 claims
- 4995US9969800B2IL-8 antibodiesCHUGAI PHARMACEUTICAL CO LTD·Filed 2016·Granted May 15, 2018·37 cites·36 claims
- 5095US6908610B1Long-term stabilized formulationsCHUGAI PHARMACEUTICAL CO LTD·Filed 2000·Granted Jun 21, 2005·76 cites·20 claims
Showing the top 50 of 1,238 patent records by PatentIndex Score.
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