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US21 patents

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US8063015B2Nov 22, 2011

Glycopegylation methods and proteins/peptides produced by the methods

DEFREES SHAWN54 citations96
US8247381B2Aug 21, 2012

Branched water-soluble polymers and their conjugates

DEFREES SHAWN21 citations93
US8716239B2May 6, 2014

Granulocyte colony stimulating factor: remodeling and glycoconjugation G-CSF

DEFREES SHAWN23 citations92
US8716240B2May 6, 2014

Erythropoietin: remodeling and glycoconjugation of erythropoietin

DEFREES SHAWN27 citations92
US8633157B2Jan 21, 2014

Glycopegylated erythropoietin

DEFREES SHAWN24 citations92
US8268967B2Sep 18, 2012

Glycopegylated interferon α

DEFREES SHAWN24 citations91
US8969532B2Mar 3, 2015

Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography

DEFREES SHAWN24 citations88
US9200049B2Dec 1, 2015

Remodeling and glycopegylation of fibroblast growth factor (FGF)

DEFREES SHAWN6 citations84
US9187532B2Nov 17, 2015

Glycosylation of peptides via O-linked glycosylation sequences

DEFREES SHAWN14 citations84
US8853161B2Oct 7, 2014

Glycopegylation methods and proteins/peptides produced by the methods

DEFREES SHAWN13 citations84
US8791066B2Jul 29, 2014

Branched PEG remodeling and glycosylation of glucagon-like peptide-1 [GLP-1]

DEFREES SHAWN11 citations84
US8198045B2Jun 12, 2012

Expression of O-glycosylated therapeutic proteins in prokaryotic microorganisms

DEFREES SHAWN12 citations82
US8076292B2Dec 13, 2011

Factor VIII: remodeling and glycoconjugation of factor VIII

DEFREES SHAWN6 citations74
US8911967B2Dec 16, 2014

One pot desialylation and glycopegylation of therapeutic peptides

DEFREES SHAWN5 citations68
US9005625B2Apr 14, 2015

Antibody toxin conjugates

DEFREES SHAWN3 citations62
US9029331B2May 12, 2015

Glycopegylated granulocyte colony stimulating factor

DEFREES SHAWN3 citations59
US8916360B2Dec 23, 2014

Glycopegylated erythropoietin

DEFREES SHAWN3 citations57
US8404809B2Mar 26, 2013

Glycopegylated factor IX

DEFREES SHAWN4 citations57
US9187546B2Nov 17, 2015

Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants

DEFREES SHAWN1 citations52
US8632770B2Jan 21, 2014

Glycopegylated factor IX

DEFREES SHAWN1 citations47
US9493499B2Nov 15, 2016

Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography

DEFREES SHAWN0 citations42