Assignee
GRAIL INC
US25 patents
Top patents by PatentIndex Score
US10144962B2Dec 4, 2018
Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
GRAIL INC5 citations79
US12410482B2Sep 9, 2025
Methylation markers and targeted methylation probe panel
GRAIL INC1 citations72
US10487358B2Nov 26, 2019
Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
GRAIL INC1 citations68
US11773450B2Oct 3, 2023
Methylation-based false positive duplicate marking reduction
GRAIL INC2 citations65
US12385037B2Aug 12, 2025
Enrichment of short nucleic acid fragments in sequencing library preparation
GRAIL INC0 citations61
US11459616B2Oct 4, 2022
Methods and systems for tumor detection
GRAIL INC1 citations61
US12509726B2Dec 30, 2025
Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing
GRAIL INC0 citations60
US12435375B2Oct 7, 2025
Methylation markers and targeted methylation probe panel
GRAIL INC1 citations60
US10822651B2Nov 3, 2020
Methods for single-stranded nucleic acid library preparation
GRAIL INC1 citations59
US12380964B2Aug 5, 2025
Convolutional neural network systems and methods for data classification
GRAIL INC0 citations58
US10907206B2Feb 2, 2021
Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
GRAIL INC0 citations58
US11473137B2Oct 18, 2022
Alignment free filtering for identifying fusions
GRAIL INC1 citations53
US12237053B2Feb 25, 2025
Detecting cross-contamination in sequencing data
GRAIL INC0 citations52
US11274344B2Mar 15, 2022
Enhanced ligation in sequencing library preparation
GRAIL INC0 citations51
US12006533B2Jun 11, 2024
Detecting cross-contamination in sequencing data using regression techniques
GRAIL INC0 citations50
US10982351B2Apr 20, 2021
Methods for high efficiency library preparation using double-stranded adapters
GRAIL INC0 citations50
US10626443B2Apr 21, 2020
Methods of analyzing nucleic acid fragments
GRAIL INC0 citations50
US12580051B2Mar 17, 2026
Identifying methylation patterns that discriminate or indicate a cancer condition
GRAIL INC0 citations49
US12100483B2Sep 24, 2024
Base coverage normalization and use thereof in detecting copy number variation
GRAIL INC0 citations49
US11414656B2Aug 16, 2022
Methods for enriching for duplex reads in sequencing and error correction
GRAIL INC0 citations49
US12497662B2Dec 16, 2025
Systems and methods for tumor fraction estimation from small variants
GRAIL INC0 citations47
US12499972B2Dec 16, 2025
Identifying false positive variants using a significance model
GRAIL INC0 citations46
US12460269B2Nov 4, 2025
Methods for analyzing viral nucleic acid
GRAIL INC0 citations45
US11961589B2Apr 16, 2024
Models for targeted sequencing
GRAIL INC0 citations42
US11118222B2Sep 14, 2021
Higher target capture efficiency using probe extension
GRAIL INC0 citations38