Assignee
HYBRIDON INC
US·97 granted patents·14 pending applications·8,315 citations·filing 1990–2010
Top patents by PatentIndex Score
111 records- 0199US5510475AOligonucleotide multiple reporter precursorsHYBRIDON INC·Filed 1994·Granted Apr 23, 1996·853 cites·3 claims
- 0298US6608035B1Method of down-regulating gene expressionHYBRIDON INC·Filed 2000·Granted Aug 19, 2003·279 cites·2 claims
- 0398US6476000B1Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosidesHYBRIDON INC·Filed 2000·Granted Nov 5, 2002·156 cites·6 claims
- 0498US6383752B1Pseudo-cyclic oligonucleobasesHYBRIDON INC·Filed 2000·Granted May 7, 2002·200 cites·33 claims
- 0598US6346614B1Hybrid oligonucleotide phosphorothioatesHYBRIDON INC·Filed 2000·Granted Feb 12, 2002·381 cites·15 claims
- 0698US5652356AInverted chimeric and hybrid oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jul 29, 1997·603 cites·2 claims
- 0797US5814620AInhibition of neovascularization using vegf-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Sep 29, 1998·329 cites·8 claims
- 0897US5591721AMethod of down-regulating gene expressionHYBRIDON INC·Filed 1994·Granted Jan 7, 1997·426 cites·1 claims
- 0996US6936593B1Method of down-regulating gene expressionHYBRIDON INC·Filed 2001·Granted Aug 30, 2005·111 cites·20 claims
- 1096US6426334B1Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammalHYBRIDON INC·Filed 1997·Granted Jul 30, 2002·210 cites·1 claims
- 1196US5886165AMixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segmentsHYBRIDON INC·Filed 1996·Granted Mar 23, 1999·206 cites·15 claims
- 1296US5856462AOligonucleotides having modified CpG dinucleosidesHYBRIDON INC·Filed 1996·Granted Jan 5, 1999·231 cites·7 claims
- 1395US6815429B2Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosidesHYBRIDON INC·Filed 2001·Granted Nov 9, 2004·53 cites·8 claims
- 1494US5968909AMethod of modulating gene expression with reduced immunostimulatory responseHYBRIDON INC·Filed 1995·Granted Oct 19, 1999·148 cites·19 claims
- 1594US5773601AInverted chimeric and hybrid oligonucleotidesHYBRIDON INC·Filed 1997·Granted Jun 30, 1998·123 cites·2 claims
- 1694US5321131ASite-specific functionalization of oligodeoxynucleotides for non-radioactive labellingHYBRIDON INC·Filed 1990·Granted Jun 14, 1994·1.3k cites·1 claims
- 1793US5693773ATriplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidinesHYBRIDON INC·Filed 1995·Granted Dec 2, 1997·118 cites·14 claims
- 1891US5705629AMethods for H-phosphonate synthesis of mono- and oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jan 6, 1998·189 cites·18 claims
- 1991US5691316ACyclodextrin cellular delivery system for oligonucleotidesHYBRIDON INC·Filed 1994·Granted Nov 25, 1997·92 cites·16 claims
- 2090US6013786AMDM2-specific antisense oligonucleotidesHYBRIDON INC·Filed 1998·Granted Jan 11, 2000·120 cites·18 claims
- 2190US5912332AAffinity-based purification of oligonucleotides using soluble multimeric oligonucleotidesHYBRIDON INC·Filed 1996·Granted Jun 15, 1999·140 cites·14 claims
- 2290US5739308AIntegrated oligonucleotidesHYBRIDON INC·Filed 1995·Granted Apr 14, 1998·106 cites·4 claims
- 2390US5554744AMethod for loading solid supports for nucleic acid synthesisHYBRIDON INC·Filed 1994·Granted Sep 10, 1996·141 cites·27 claims
- 2487US5929226AAntisense oligonucleotide alkylphosphonothioates and arylphospohonothioatesHYBRIDON INC·Filed 1995·Granted Jul 27, 1999·151 cites·20 claims
- 2587US5614622A5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide synthesesHYBRIDON INC·Filed 1995·Granted Mar 25, 1997·95 cites·5 claims
- 2686US5739314AMethod for synthesizing 2'-O-substituted pyrimidine nucleosidesHYBRIDON INC·Filed 1997·Granted Apr 14, 1998·90 cites·6 claims
- 2786US5639872AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 17, 1997·54 cites·1 claims
- 2885US6117992AReagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkagesHYBRIDON INC·Filed 1997·Granted Sep 12, 2000·82 cites·14 claims
- 2985US5962674ASynthesis of oligonucleotides containing alkylphosphonate internucleoside linkagesHYBRIDON INC·Filed 1996·Granted Oct 5, 1999·89 cites·2 claims
- 3084US6140482APrimary phosphoramidate internucleoside linkages and oligonucleotides containing the sameHYBRIDON INC·Filed 1995·Granted Oct 31, 2000·84 cites·6 claims
- 3183US5955599AProcess for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkagesHYBRIDON INC·Filed 1995·Granted Sep 21, 1999·83 cites·14 claims
- 3283US5801156AInhibition of neovascularization using VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Sep 1, 1998·45 cites·8 claims
- 3382US6410322B1Antisense oligonucleotide inhibition of vascular endothelial growth factor expressionHYBRIDON INC·Filed 1993·Granted Jun 25, 2002·44 cites·10 claims
- 3482US5684147ATherapeutic anti-HIV anti-viral oligonucleotides and pharmaceutical formulations thereofHYBRIDON INC·Filed 1994·Granted Nov 4, 1997·67 cites·2 claims
- 3582US5661135AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Aug 26, 1997·43 cites·12 claims
- 3682US5639736AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 17, 1997·42 cites·1 claims
- 3780US6372427B1Cooperative oligonucleotidesHYBRIDON INC·Filed 1995·Granted Apr 16, 2002·46 cites·22 claims
- 3880US5545729AStabilized ribozyme analogsHYBRIDON INC·Filed 1994·Granted Aug 13, 1996·95 cites·28 claims
- 3979US5668268APassivated polymer supports for nucleic acid synthesisHYBRIDON INC·Filed 1995·Granted Sep 16, 1997·49 cites·8 claims
- 4079US5403709AMethod for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkagesHYBRIDON INC·Filed 1992·Granted Apr 4, 1995·65 cites·6 claims
- 4178US5710136AInhibition of neovascularization using VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jan 20, 1998·33 cites·8 claims
- 4276US6667293B1Use of cyclodextrins to modulate gene expression with reduced immunostimulatory responseHYBRIDON INC·Filed 1995·Granted Dec 23, 2003·34 cites·9 claims
- 4375US5807525AApparatus and process for multi stage solid phase synthesis of long chained organic moleculesHYBRIDON INC·Filed 1996·Granted Sep 15, 1998·54 cites·53 claims
- 4474US6489464B1Branched oligonucleotides as pathogen-inhibitory agentsHYBRIDON INC·Filed 1996·Granted Dec 3, 2002·45 cites·8 claims
- 4572US5641756AModified VEGF oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 24, 1997·32 cites·25 claims
- 4671US6605708B1Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefromHYBRIDON INC·Filed 1993·Granted Aug 12, 2003·24 cites·13 claims
- 4769US6399586B1Modified VEGF oligonucleotidesHYBRIDON INC·Filed 1999·Granted Jun 4, 2002·18 cites·8 claims
- 4868US6485973B1Oligonucleotides specific for the marORAB operonHYBRIDON INC·Filed 2000·Granted Nov 26, 2002·1 cites·21 claims
- 4968US6087491AExtremely high purity oligonucleotides and methods of synthesizing them using dimer blocksHYBRIDON INC·Filed 1997·Granted Jul 11, 2000·25 cites·1 claims
- 5067US6531589B1Base protecting groups and synthons for oligonucleotide synthesisHYBRIDON INC·Filed 1996·Granted Mar 11, 2003·24 cites·37 claims
Showing the top 50 of 111 patent records by PatentIndex Score.
Counts cover granted patents and pending applications in the PatentIndex corpus. How scoring works →