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ISIS PHARMACEUTICALS INC
US895 patents
Top patents by PatentIndex Score
US9181549B2Nov 10, 2015
Conjugated antisense compounds and their use
ISIS PHARMACEUTICALS INC69 citations99
US9127276B2Sep 8, 2015
Conjugated antisense compounds and their use
ISIS PHARMACEUTICALS INC136 citations99
US9005906B2Apr 14, 2015
Tetrahydropyran nucleic acid analogs
ISIS PHARMACEUTICALS INC163 citations99
US8030467B2Oct 4, 2011
5′-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC327 citations99
US8022193B2Sep 20, 2011
6-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC335 citations99
US7750131B2Jul 6, 2010
5′-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC202 citations99
US7745609B2Jun 29, 2010
Antisense modulation of CD40 expression
ISIS PHARMACEUTICALS INC189 citations99
US7741457B2Jun 22, 2010
6-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC542 citations99
US7741305B2Jun 22, 2010
Modulation of apolipoprotein (a) expression
ISIS PHARMACEUTICALS INC135 citations99
US7732590B2Jun 8, 2010
Modulation of diacylglycerol acyltransferase 2 expression
ISIS PHARMACEUTICALS INC132 citations99
US7723508B2May 25, 2010
Modulation of apolipoprotein (A) expression
ISIS PHARMACEUTICALS INC136 citations99
US7695902B2Apr 13, 2010
Oligoribonucleotides and ribonucleases for cleaving RNA
ISIS PHARMACEUTICALS INC201 citations99
US7696345B2Apr 13, 2010
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
ISIS PHARMACEUTICALS INC426 citations99
US7666854B2Feb 23, 2010
Bis-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC308 citations99
US7629321B2Dec 8, 2009
Oligoribonucleotides and ribonucleases for cleaving RNA
ISIS PHARMACEUTICALS INC146 citations99
US7547684B2Jun 16, 2009
5′-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC413 citations99
US7468431B2Dec 23, 2008
Modulation of eIF4E-BP2 expression
ISIS PHARMACEUTICALS INC117 citations99
US7432250B2Oct 7, 2008
Oligoribonucleotides and ribonucleases for cleaving RNA
ISIS PHARMACEUTICALS INC198 citations99
US7432249B2Oct 7, 2008
Oligoribonucleotides and ribonucleases for cleaving RNA
ISIS PHARMACEUTICALS INC147 citations99
US7425545B2Sep 16, 2008
Modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC158 citations99
US7399853B2Jul 15, 2008
Modulation of glucagon receptor expression
ISIS PHARMACEUTICALS INC105 citations99
US7399845B2Jul 15, 2008
6-modified bicyclic nucleic acid analogs
ISIS PHARMACEUTICALS INC1,088 citations99
US7255992B2Aug 14, 2007
Methods for rapid detection and identification of bioagents for environmental and product testing
ISIS PHARMACEUTICALS INC154 citations99
US7226739B2Jun 5, 2007
Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
ISIS PHARMACEUTICALS INC146 citations99
US7217510B2May 15, 2007
Methods for providing bacterial bioagent characterizing information
ISIS PHARMACEUTICALS INC131 citations99
US7217572B2May 15, 2007
Modulation of HIF1α and HIF2α expression
ISIS PHARMACEUTICALS INC139 citations99
USRE39464EJan 9, 2007
Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages
ISIS PHARMACEUTICALS INC235 citations99
US7144999B2Dec 5, 2006
Modulation of hypoxia-inducible factor 1 alpha expression
ISIS PHARMACEUTICALS INC115 citations99
US7108974B2Sep 19, 2006
Method for rapid detection and identification of bioagents
ISIS PHARMACEUTICALS INC148 citations99
US7105499B2Sep 12, 2006
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
ISIS PHARMACEUTICALS INC233 citations99
US7037646B1May 2, 2006
Amine-derivatized nucleosides and oligonucleosides
ISIS PHARMACEUTICALS INC197 citations99
US7015315B1Mar 21, 2006
Gapped oligonucleotides
ISIS PHARMACEUTICALS INC409 citations99
US6900297B1May 31, 2005
Amine-derivatized nucleosides and oligonucleosides
ISIS PHARMACEUTICALS INC187 citations99
US6878805B2Apr 12, 2005
Peptide-conjugated oligomeric compounds
ISIS PHARMACEUTICALS INC218 citations99
US6867294B1Mar 15, 2005
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
ISIS PHARMACEUTICALS INC380 citations99
US6783931B1Aug 31, 2004
Amine-derivatized nucleosides and oligonucleosides
ISIS PHARMACEUTICALS INC194 citations99
US6762169B1Jul 13, 2004
Ligand-conjugated oligomeric compounds
ISIS PHARMACEUTICALS INC150 citations99
US6710174B2Mar 23, 2004
Antisense inhibition of vascular endothelial growth factor receptor-1 expression
ISIS PHARMACEUTICALS INC155 citations99
US6660720B2Dec 9, 2003
Targeted oligonucleotide conjugates
ISIS PHARMACEUTICALS INC168 citations99
US6656730B1Dec 2, 2003
Oligonucleotides conjugated to protein-binding drugs
ISIS PHARMACEUTICALS INC226 citations99
US6639062B2Oct 28, 2003
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
ISIS PHARMACEUTICALS INC259 citations99
US6600032B1Jul 29, 2003
2′-O-aminoethyloxyethyl-modified oligonucleotides
ISIS PHARMACEUTICALS INC338 citations99
US6566131B1May 20, 2003
Antisense modulation of Smad6 expression
ISIS PHARMACEUTICALS INC366 citations99
US6566135B1May 20, 2003
Antisense modulation of caspase 6 expression
ISIS PHARMACEUTICALS INC379 citations99
US6559279B1May 6, 2003
Process for preparing peptide derivatized oligomeric compounds
ISIS PHARMACEUTICALS INC181 citations99
US6534639B1Mar 18, 2003
Guanidinium functionalized oligonucleotides and method/synthesis
ISIS PHARMACEUTICALS INC261 citations99
US6528631B1Mar 4, 2003
Oligonucleotide-folate conjugates
ISIS PHARMACEUTICALS INC461 citations99
US6525031B2Feb 25, 2003
Targeted Oligonucleotide conjugates
ISIS PHARMACEUTICALS INC256 citations99
US6476205B1Nov 5, 2002
2′ Modified oligonucleotides
ISIS PHARMACEUTICALS INC305 citations99
US6451991B1Sep 17, 2002
Sugar-modified gapped oligonucleotides
ISIS PHARMACEUTICALS INC244 citations99
Showing the top 50 of 895 patents by PatentIndex Score.