Assignee
VICAL INC
US48 patents
Top patents by PatentIndex Score
US5589466ADec 31, 1996
Induction of a protective immune response in a mammal by injecting a DNA sequence
VICAL INC2,447 citations99
US5580859ADec 3, 1996
Delivery of exogenous DNA sequences in a mammal
VICAL INC3,073 citations99
US5194654AMar 16, 1993
Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
VICAL INC411 citations99
US6413942B1Jul 2, 2002
Methods of delivering a physiologically active polypeptide to a mammal
VICAL INC261 citations98
US6214804B1Apr 10, 2001
Induction of a protective immune response in a mammal by injecting a DNA sequence
VICAL INC481 citations98
US5693622ADec 2, 1997
Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
VICAL INC434 citations98
US5223263AJun 29, 1993
Liponucleotide-containing liposomes
VICAL INC446 citations98
US6586409B1Jul 1, 2003
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
VICAL INC121 citations97
US5459127AOct 17, 1995
Cationic lipids for intracellular delivery of biologically active molecules
VICAL INC1,243 citations97
US5264618ANov 23, 1993
Cationic lipids for intracellular delivery of biologically active molecules
VICAL INC957 citations97
US6147055ANov 14, 2000
Cancer treatment method utilizing plasmids suitable for IL-2 expression
VICAL INC167 citations96
US5910488AJun 8, 1999
Plasmids suitable for gene therapy
VICAL INC145 citations96
US7628993B2Dec 8, 2009
Compositions and methods for vaccinating against HSV-2
VICAL INC44 citations95
US7268120B1Sep 11, 2007
Methods for treating cancer using cytokine-expressing polynucleotides
VICAL INC127 citations95
US6710035B2Mar 23, 2004
Generation of an immune response to a pathogen
VICAL INC52 citations95
US6670332B1Dec 30, 2003
Complex cationic lipids having quarternary nitrogens therein
VICAL INC58 citations95
US6022874AFeb 8, 2000
Piperazine based cytofectins
VICAL INC74 citations95
US5861397AJan 19, 1999
Piperazine based cytofectins
VICAL INC86 citations95
US5364840ANov 15, 1994
Synthetic calcitonin peptides
VICAL INC53 citations95
US7888112B2Feb 15, 2011
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
VICAL INC34 citations94
US7537768B2May 26, 2009
Influenza virus vaccine composition and methods of use
VICAL INC41 citations94
US7410795B2Aug 12, 2008
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
VICAL INC36 citations94
US6875748B2Apr 5, 2005
Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
VICAL INC83 citations93
US6399588B1Jun 4, 2002
Cancer treatment method utilizing plasmids suitable for IL-2 expression
VICAL INC40 citations93
US5641665AJun 24, 1997
Plasmids suitable for IL-2 expression
VICAL INC66 citations93
US5561064AOct 1, 1996
Production of pharmaceutical-grade plasmid DNA
VICAL INC111 citations93
US6867195B1Mar 15, 2005
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
VICAL INC20 citations92
US6706694B1Mar 16, 2004
Expression of exogenous polynucleotide sequences in a vertebrate
VICAL INC22 citations92
US6228844B1May 8, 2001
Stimulating vascular growth by administration of DNA sequences encoding VEGF
VICAL INC49 citations92
US5175146ADec 29, 1992
Synthetic calcitonin peptides
VICAL INC26 citations92
US7935352B2May 3, 2011
Compositions and methods for vaccinating against HSV-2
VICAL INC9 citations91
US7879339B2Feb 1, 2011
Compositions and methods for vaccinating against HSV-2
VICAL INC11 citations91
US7785603B2Aug 31, 2010
Influenza virus vaccine composition and methods of use
VICAL INC20 citations91
US7105574B1Sep 12, 2006
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
VICAL INC35 citations91
US5994317ANov 30, 1999
Quaternary cytofectins
VICAL INC46 citations91
US5891718AApr 6, 1999
Tetracycline inducible/repressible systems
VICAL INC33 citations91
US5707812AJan 13, 1998
Purification of plasmid DNA during column chromatography
VICAL INC83 citations90
US6696424B1Feb 24, 2004
Cytofectin dimers and methods of use thereof
VICAL INC158 citations89
US5576196ANov 19, 1996
Process for reducing RNA concentration in a mixture of biological material using diatomaceous earth
VICAL INC31 citations88
US7521187B2Apr 21, 2009
Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
VICAL INC10 citations84
US9180162B2Nov 10, 2015
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
VICAL INC7 citations82
US7470675B2Dec 30, 2008
Methods for treating cancer using interferon-ω-expressing polynucleotides
VICAL INC9 citations80
US7381422B2Jun 3, 2008
Method for producing sterile polynucleotide based medicaments
VICAL INC9 citations80
US9102950B2Aug 11, 2015
Compositions and methods for enhancing immune responses to vaccines
VICAL INC9 citations77
US6673776B1Jan 6, 2004
Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
VICAL INC10 citations73
US9205146B2Dec 8, 2015
Compositions and methods for vaccinating against HSV-2
VICAL INC0 citations62
US9161973B2Oct 20, 2015
Compositions and methods for vaccinating against HSV-2
VICAL INC0 citations62
US7582613B2Sep 1, 2009
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
VICAL INC4 citations61