Assignee
BUCK INST RES AGING
US·32 granted patents·24 pending applications·144 citations·filing 2013–2025
Top patents by PatentIndex Score
56 records- 0198US10010546B2Treatment of ophthalmic conditions by selectively removing senescent cells from the eyeBUCK INST RES AGING·Filed 2017·Granted Jul 3, 2018·23 cites·11 claims
- 0297US9849128B2Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cellsBUCK INST RES AGING·Filed 2017·Granted Dec 26, 2017·24 cites·15 claims
- 0396US9993472B2Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2BUCK INST RES AGING·Filed 2015·Granted Jun 12, 2018·20 cites·7 claims
- 0496US9980962B2Use of sulfonamide inhibitors of Bcl-2 to treat senescence-associated lung conditions such as pulmonary fibrosis and chronic obstructive pulmonary diseaseBUCK INST RES AGING·Filed 2017·Granted May 29, 2018·6 cites·8 claims
- 0596US9855266B2Treatment for osteoarthritis by intra-articular administration of a cis-imidazolineBUCK INST RES AGING·Filed 2017·Granted Jan 2, 2018·12 cites·14 claims
- 0694US10478432B2Compositions of matter for treatment of ophthalmic conditions by selectively removing senescent cells from the eyeBUCK INST RES AGING·Filed 2018·Granted Nov 19, 2019·7 cites·18 claims
- 0794US9901080B2Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cellsBUCK INST RES AGING·Filed 2016·Granted Feb 27, 2018·16 cites·20 claims
- 0892US10258618B2Treating pulmonary conditions by selectively removing senescent cells from the lung using an intermittent dosing regimenBUCK INST RES AGING·Filed 2018·Granted Apr 16, 2019·5 cites·17 claims
- 0991US10213426B2Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell populationBUCK INST RES AGING·Filed 2017·Granted Feb 26, 2019·5 cites·13 claims
- 1090US11351167B2Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissueBUCK INST RES AGING·Filed 2019·Granted Jun 7, 2022·1 cites·14 claims
- 1190US10413542B2Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders using an inhibitor of Akt kinaseBUCK INST RES AGING·Filed 2018·Granted Sep 17, 2019·4 cites·12 claims
- 1287US9926280B2Hydantoins that modulate BACE-mediated APP processingBUCK INST RES AGING·Filed 2015·Granted Mar 27, 2018·4 cites·16 claims
- 1386US9884065B2Inhibiting activity of senescent cells using a glucocorticoidBUCK INST RES AGING·Filed 2016·Granted Feb 6, 2018·5 cites·15 claims
- 1485US10835546B2App specific BACE inhibitors (ASBIs) and uses thereofBUCK INST RES AGING·Filed 2019·Granted Nov 17, 2020·1 cites·16 claims
- 1584US10202355B2Hydantoins that modulate bace-mediated app processingBUCK INST RES AGING·Filed 2014·Granted Feb 12, 2019·4 cites·8 claims
- 1682US12285427B2Treatment of a senescence-associated ocular disease or disorder using a Bcl-xL selective inhibitorBUCK INST RES AGING·Filed 2023·Granted Apr 29, 2025·0 cites·4 claims
- 1782US9901081B2Transgenic mouse for determining the role of senescent cells in cancerBUCK INST RES AGING·Filed 2016·Granted Feb 27, 2018·2 cites·12 claims
- 1881US12037317B2Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compoundsBUCK INST RES AGING·Filed 2019·Granted Jul 16, 2024·1 cites·6 claims
- 1979US11980616B2Treating liver disease by selectively eliminating senescent cellsBUCK INST RES AGING·Filed 2020·Granted May 14, 2024·0 cites·23 claims
- 2078US11963957B2Treating cardiovascular disease by selectively eliminating senescent cellsBUCK INST RES AGING·Filed 2020·Granted Apr 23, 2024·0 cites·24 claims
- 2177US11773051B2S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using sameBUCK INST RES AGING·Filed 2018·Granted Oct 3, 2023·2 cites·16 claims
- 2277US2021030752A1Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissueBUCK INST RES AGING·Filed 2020·Application pending·0 cites
- 2377US2024317671A1Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compoundsBUCK INST RES AGING·Filed 2024·Application pending·0 cites
- 2476US10357508B2APP specific BACE inhibitors (ASBIs) and uses thereofBUCK INST RES AGING·Filed 2013·Granted Jul 23, 2019·2 cites·11 claims
- 2572US11091444B2Hydantoins that modulate BACE-mediated app processingBUCK INST RES AGING·Filed 2020·Granted Aug 17, 2021·0 cites·12 claims
- 2671US2019175623A1Chemical compounds for treating atherosclerosis by stabilizing atherosclerotic plaques or delaying atherogenesisBUCK INST RES AGING·Filed 2018·Application pending·0 cites
- 2770US2024269098A1Formulations for extending lifespan and healthspanBUCK INST RES AGING·Filed 2023·Application pending·0 cites
- 2869US2023127906A1Formulations for extending lifespan and healthspanBUCK INST RES AGING·Filed 2022·Application pending·0 cites
- 2967US2018110787A1Treatment for Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary DiseaseBUCK INST RES AGING·Filed 2017·Application pending·0 cites
- 3066USRE49873EAPP specific bace inhibitors (ASBIs) and uses thereofBUCK INST RES AGING·Filed 2013·Granted Mar 19, 2024·0 cites·11 claims
- 3166US10766867B2Hydantoins that modulate BACE-mediated APP processingBUCK INST RES AGING·Filed 2017·Granted Sep 8, 2020·0 cites·16 claims
- 3265US10844071B2Substituted [1,2,3]triazolo[4,5-d]pyrimidines that lower stress-induced p-tauBUCK INST RES AGING·Filed 2020·Granted Nov 24, 2020·0 cites·7 claims
- 3365US2020017449A1Hydantoins that modulate bace-mediated app processingBUCK INST RES AGING·Filed 2019·Application pending·0 cites
- 3463US10655144B2Nucleic acid construct with a p16 promoter that causes a prodrug converting enzyme to be expressed specifically in senescent cellsBUCK INST RES AGING·Filed 2018·Granted May 19, 2020·0 cites·10 claims
- 3560US2025282707A1Novel ketone ester compoundsBUCK INST RES AGING·Filed 2023·Application pending·0 cites
- 3658US2020188327A1Formulations for extending lifespan and healthspanBUCK INST RES AGING·Filed 2018·Application pending·0 cites
- 3757US2024216316A1Dihomo-gamma linolenic acid (dgla) is a novel senolyticBUCK INST RES AGING·Filed 2021·Application pending·0 cites
- 3856US2024180891A1Synergistic modulators of alpha-dicarbonyl detoxification and their use for inducing weight loss and the treatment of diabetic pathologiesBUCK INST RES AGING·Filed 2021·Application pending·0 cites
- 3955US2023390232A1N-propargylglycine: a unique inhibitor of proline dehydrogenase with brain-enhancing mitohormesis properties capable of mitigating the pathogenesis of neurodegenerative disordersBUCK INST RES AGING·Filed 2021·Application pending·0 cites
- 4054US2025283069A1Gene-drive in dna virusesBUCK INST RES AGING·Filed 2025·Application pending·0 cites
- 4152US2022265605A1Methods of inducing autophagy using coumarin derivatives and related compoundsBUCK INST RES AGING·Filed 2020·Application pending·0 cites
- 4252US2024122890A1Use of exogenous ketone esters to induce weight loss in mammalsBUCK INST RES AGING·Filed 2022·Application pending·0 cites
- 4350US12344837B2Gene-drive in DNA virusesBUCK INST RES AGING·Filed 2019·Granted Jul 1, 2025·0 cites·17 claims
- 4450US10618899B2Substituted [1,2,3]triazolo[4,5-d]pyrimidines that lower stress-induced p-tauBUCK INST RES AGING·Filed 2016·Granted Apr 14, 2020·0 cites·11 claims
- 4548US2022241316A125-hydroxycholesterol (25hc), cryab aggregation inhibitor, is a novel senolyticBUCK INST RES AGING·Filed 2020·Application pending·0 cites
- 4648US2022241229A1Methods and Compositions for Altering Senescence Associated Secretory PhenotypeBUCK INST RES AGING·Filed 2020·Application pending·0 cites
- 4748US2023092706A1Treatment of viral pathologies with exogenous ketonesBUCK INST RES AGING·Filed 2021·Application pending·0 cites
- 4847US10052305B2Lipoic acid and derivatives thereof for the treatment of cystinuriaBUCK INST RES AGING·Filed 2016·Granted Aug 21, 2018·0 cites·7 claims
- 4946US2022000873A1S3qels to protect against intestinal permeabilityBUCK INST RES AGING·Filed 2019·Application pending·0 cites
- 5045US2025049815A125-hydroxycholesterol (25hc), cryab aggregation inhibitor to amelioriate vascular stiffnessBUCK INST RES AGING·Filed 2022·Application pending·0 cites
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