Assignee
CHANG CHIEN-HSING
US·21 granted patents·4 pending applications·655 citations·filing 2009–2012
Top patents by PatentIndex Score
25 records- 0198US8597659B2Tetrameric cytokines with improved biological activityCHANG CHIEN-HSING·Filed 2011·Granted Dec 3, 2013·50 cites·12 claims
- 0298US8562988B2Strategies for improved cancer vaccinesCHANG CHIEN-HSING·Filed 2010·Granted Oct 22, 2013·44 cites·16 claims
- 0398US8551480B2Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activityCHANG CHIEN-HSING·Filed 2010·Granted Oct 8, 2013·48 cites·3 claims
- 0498US8475794B2Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, Autoimmune disease and other diseasesCHANG CHIEN-HSING·Filed 2011·Granted Jul 2, 2013·44 cites·7 claims
- 0598US8282934B2Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technologyCHANG CHIEN-HSING·Filed 2011·Granted Oct 9, 2012·49 cites·17 claims
- 0698US8277817B2PEGylation by the dock and lock (DNL) techniqueCHANG CHIEN-HSING·Filed 2011·Granted Oct 2, 2012·44 cites·11 claims
- 0798US8246960B2Methods and compositions for generating bioactive assemblies of increased complexity and usesCHANG CHIEN-HSING·Filed 2011·Granted Aug 21, 2012·55 cites·21 claims
- 0898US8211440B2Multivalent immunoglobulin-based bioactive assembliesCHANG CHIEN-HSING·Filed 2010·Granted Jul 3, 2012·57 cites·25 claims
- 0998US8163291B2Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and usesCHANG CHIEN-HSING·Filed 2009·Granted Apr 24, 2012·52 cites·28 claims
- 1097US8491914B2Dock-and-lock (DNL) complexes for delivery of interference RNACHANG CHIEN-HSING·Filed 2010·Granted Jul 23, 2013·46 cites·2 claims
- 1197US8481041B2Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapyCHANG CHIEN-HSING·Filed 2011·Granted Jul 9, 2013·45 cites·11 claims
- 1297US8435540B2Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in VIVOCHANG CHIEN-HSING·Filed 2012·Granted May 7, 2013·47 cites·9 claims
- 1397US8158129B2Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivoCHANG CHIEN-HSING·Filed 2011·Granted Apr 17, 2012·49 cites·10 claims
- 1495US8865176B2Methods and compositions for generating bioactive assemblies of increased complexity and usesCHANG CHIEN-HSING·Filed 2012·Granted Oct 21, 2014·9 cites·4 claims
- 1585US8932593B2Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and usesCHANG CHIEN-HSING·Filed 2012·Granted Jan 13, 2015·5 cites·13 claims
- 1684US8883160B2Dock-and-lock (DNL) complexes for therapeutic and diagnostic useCHANG CHIEN-HSING·Filed 2011·Granted Nov 11, 2014·7 cites·3 claims
- 1781US8906377B2Stably tethered structures of defined compositions with multiple functions or binding specificitiesCHANG CHIEN-HSING·Filed 2010·Granted Dec 9, 2014·3 cites·11 claims
- 1870US9623115B2Dock-and-Lock (DNL) Complexes for Disease TherapyCHANG CHIEN-HSING·Filed 2011·Granted Apr 18, 2017·1 cites·3 claims
- 1967US9617531B2Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lockCHANG CHIEN-HSING·Filed 2012·Granted Apr 11, 2017·0 cites·6 claims
- 2062US9457072B2Dock-and-lock (DNL) vaccines for cancer therapyCHANG CHIEN-HSING·Filed 2011·Granted Oct 4, 2016·0 cites·9 claims
- 2162US9457100B2PEGylation by the dock and lock (DNL) techniqueCHANG CHIEN-HSING·Filed 2012·Granted Oct 4, 2016·0 cites·5 claims
- 2261US2012276608A1Multivalent Immunoglobulin-Based Bioactive AssembliesCHANG CHIEN-HSING·Filed 2012·Application pending·0 cites
- 2358US2013164214A1Antibody-Based Depletion of Antigen-Presenting Cells and Dendritic CellsCHANG CHIEN-HSING·Filed 2012·Application pending·0 cites
- 2450US2013306700A1Stapler with leg-flattening and anvil-limiting capabilityCHANG CHIEN-HSING·Filed 2012·Application pending·0 cites
- 2544US2012276100A1Compositions and Methods of Use of Immunotoxins Comprising Ranpirnase (Rap) Show Potent Cytotoxic ActivityCHANG CHIEN-HSING·Filed 2012·Application pending·0 cites
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