Assignee
HYBRIDON INC
US·97 granted patents·14 pending applications·8,315 citations·filing 1990–2010
Top patents by PatentIndex Score
111 records- 0199US5510475AOligonucleotide multiple reporter precursorsHYBRIDON INC·Filed 1994·Granted Apr 23, 1996·853 cites·3 claims
- 0298US6608035B1Method of down-regulating gene expressionHYBRIDON INC·Filed 2000·Granted Aug 19, 2003·279 cites·2 claims
- 0398US6476000B1Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosidesHYBRIDON INC·Filed 2000·Granted Nov 5, 2002·156 cites·6 claims
- 0498US6383752B1Pseudo-cyclic oligonucleobasesHYBRIDON INC·Filed 2000·Granted May 7, 2002·200 cites·33 claims
- 0598US6346614B1Hybrid oligonucleotide phosphorothioatesHYBRIDON INC·Filed 2000·Granted Feb 12, 2002·381 cites·15 claims
- 0698US5652356AInverted chimeric and hybrid oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jul 29, 1997·603 cites·2 claims
- 0797US5814620AInhibition of neovascularization using vegf-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Sep 29, 1998·329 cites·8 claims
- 0897US5591721AMethod of down-regulating gene expressionHYBRIDON INC·Filed 1994·Granted Jan 7, 1997·426 cites·1 claims
- 0996US6936593B1Method of down-regulating gene expressionHYBRIDON INC·Filed 2001·Granted Aug 30, 2005·111 cites·20 claims
- 1096US6426334B1Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammalHYBRIDON INC·Filed 1997·Granted Jul 30, 2002·210 cites·1 claims
- 1196US5886165AMixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segmentsHYBRIDON INC·Filed 1996·Granted Mar 23, 1999·206 cites·15 claims
- 1296US5856462AOligonucleotides having modified CpG dinucleosidesHYBRIDON INC·Filed 1996·Granted Jan 5, 1999·231 cites·7 claims
- 1395US6815429B2Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosidesHYBRIDON INC·Filed 2001·Granted Nov 9, 2004·53 cites·8 claims
- 1494US5968909AMethod of modulating gene expression with reduced immunostimulatory responseHYBRIDON INC·Filed 1995·Granted Oct 19, 1999·148 cites·19 claims
- 1594US5773601AInverted chimeric and hybrid oligonucleotidesHYBRIDON INC·Filed 1997·Granted Jun 30, 1998·123 cites·2 claims
- 1694US5321131ASite-specific functionalization of oligodeoxynucleotides for non-radioactive labellingHYBRIDON INC·Filed 1990·Granted Jun 14, 1994·1.3k cites·1 claims
- 1793US5693773ATriplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidinesHYBRIDON INC·Filed 1995·Granted Dec 2, 1997·118 cites·14 claims
- 1891US5705629AMethods for H-phosphonate synthesis of mono- and oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jan 6, 1998·189 cites·18 claims
- 1991US5691316ACyclodextrin cellular delivery system for oligonucleotidesHYBRIDON INC·Filed 1994·Granted Nov 25, 1997·92 cites·16 claims
- 2090US6013786AMDM2-specific antisense oligonucleotidesHYBRIDON INC·Filed 1998·Granted Jan 11, 2000·120 cites·18 claims
- 2190US5912332AAffinity-based purification of oligonucleotides using soluble multimeric oligonucleotidesHYBRIDON INC·Filed 1996·Granted Jun 15, 1999·140 cites·14 claims
- 2290US5739308AIntegrated oligonucleotidesHYBRIDON INC·Filed 1995·Granted Apr 14, 1998·106 cites·4 claims
- 2390US5554744AMethod for loading solid supports for nucleic acid synthesisHYBRIDON INC·Filed 1994·Granted Sep 10, 1996·141 cites·27 claims
- 2487US5929226AAntisense oligonucleotide alkylphosphonothioates and arylphospohonothioatesHYBRIDON INC·Filed 1995·Granted Jul 27, 1999·151 cites·20 claims
- 2587US5614622A5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide synthesesHYBRIDON INC·Filed 1995·Granted Mar 25, 1997·95 cites·5 claims
- 2686US5739314AMethod for synthesizing 2'-O-substituted pyrimidine nucleosidesHYBRIDON INC·Filed 1997·Granted Apr 14, 1998·90 cites·6 claims
- 2786US5639872AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 17, 1997·54 cites·1 claims
- 2885US6117992AReagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkagesHYBRIDON INC·Filed 1997·Granted Sep 12, 2000·82 cites·14 claims
- 2985US5962674ASynthesis of oligonucleotides containing alkylphosphonate internucleoside linkagesHYBRIDON INC·Filed 1996·Granted Oct 5, 1999·89 cites·2 claims
- 3084US6140482APrimary phosphoramidate internucleoside linkages and oligonucleotides containing the sameHYBRIDON INC·Filed 1995·Granted Oct 31, 2000·84 cites·6 claims
- 3183US5955599AProcess for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkagesHYBRIDON INC·Filed 1995·Granted Sep 21, 1999·83 cites·14 claims
- 3283US5801156AInhibition of neovascularization using VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Sep 1, 1998·45 cites·8 claims
- 3382US6410322B1Antisense oligonucleotide inhibition of vascular endothelial growth factor expressionHYBRIDON INC·Filed 1993·Granted Jun 25, 2002·44 cites·10 claims
- 3482US5684147ATherapeutic anti-HIV anti-viral oligonucleotides and pharmaceutical formulations thereofHYBRIDON INC·Filed 1994·Granted Nov 4, 1997·67 cites·2 claims
- 3582US5661135AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Aug 26, 1997·43 cites·12 claims
- 3682US5639736AHuman VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 17, 1997·42 cites·1 claims
- 3780US6372427B1Cooperative oligonucleotidesHYBRIDON INC·Filed 1995·Granted Apr 16, 2002·46 cites·22 claims
- 3880US5545729AStabilized ribozyme analogsHYBRIDON INC·Filed 1994·Granted Aug 13, 1996·95 cites·28 claims
- 3979US5668268APassivated polymer supports for nucleic acid synthesisHYBRIDON INC·Filed 1995·Granted Sep 16, 1997·49 cites·8 claims
- 4079US5403709AMethod for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkagesHYBRIDON INC·Filed 1992·Granted Apr 4, 1995·65 cites·6 claims
- 4178US5710136AInhibition of neovascularization using VEGF-specific oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jan 20, 1998·33 cites·8 claims
- 4276US6667293B1Use of cyclodextrins to modulate gene expression with reduced immunostimulatory responseHYBRIDON INC·Filed 1995·Granted Dec 23, 2003·34 cites·9 claims
- 4375US5807525AApparatus and process for multi stage solid phase synthesis of long chained organic moleculesHYBRIDON INC·Filed 1996·Granted Sep 15, 1998·54 cites·53 claims
- 4474US6489464B1Branched oligonucleotides as pathogen-inhibitory agentsHYBRIDON INC·Filed 1996·Granted Dec 3, 2002·45 cites·8 claims
- 4572US5641756AModified VEGF oligonucleotidesHYBRIDON INC·Filed 1995·Granted Jun 24, 1997·32 cites·25 claims
- 4671US6605708B1Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefromHYBRIDON INC·Filed 1993·Granted Aug 12, 2003·24 cites·13 claims
- 4769US6399586B1Modified VEGF oligonucleotidesHYBRIDON INC·Filed 1999·Granted Jun 4, 2002·18 cites·8 claims
- 4868US6485973B1Oligonucleotides specific for the marORAB operonHYBRIDON INC·Filed 2000·Granted Nov 26, 2002·1 cites·21 claims
- 4968US6087491AExtremely high purity oligonucleotides and methods of synthesizing them using dimer blocksHYBRIDON INC·Filed 1997·Granted Jul 11, 2000·25 cites·1 claims
- 5067US6531589B1Base protecting groups and synthons for oligonucleotide synthesisHYBRIDON INC·Filed 1996·Granted Mar 11, 2003·24 cites·37 claims
Showing the top 50 of 111 patent records by PatentIndex Score.
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