Inventor
KAHAN FREDERICK M
US19 patents
Patents
19 patentsUS3950357AApr 13, 1976
Antibiotics
MERCK & CO INC153 citations96
US5147868ASep 15, 1992
Thienamycin renal peptidase inhibitors
MERCK & CO INC36 citations92
US4539208ASep 3, 1985
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
MERCK & CO INC21 citations81
US4031231AJun 21, 1977
Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor
MERCK & CO INC9 citations73
US4006060AFeb 1, 1977
Thienamycin production
MERCK & CO INC17 citations73
US4000161ADec 28, 1976
Process for purifying thienamycin
MERCK & CO INC9 citations73
US5071843ADec 10, 1991
Combination of 2-substituted carbapenems with dipeptidase inhibitors
MERCK & CO INC8 citations72
US4668504AMay 26, 1987
Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics
MERCK & CO INC18 citations72
US4616038AOct 7, 1986
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
MERCK & CO INC16 citations72
US4304867ADec 8, 1981
Culture of Streptomyces cattleya
MERCK & CO INC3 citations62
US4282322AAug 4, 1981
Process for enzymatic deacylation of antibiotics
MERCK & CO INC6 citations62
US4264734AApr 28, 1981
Process for producing antibiotic desacetyl 890A10
MERCK & CO INC3 citations62
US4229534AOct 21, 1980
Acetylthienamycin production
MERCK & CO INC4 citations62
US4165379AAug 21, 1979
N-acetyl thienamycin
MERCK & CO INC3 citations62
US4028405AJun 7, 1977
Fluorinated amino acids
MERCK & CO INC5 citations62
US4880793ANov 14, 1989
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
MERCK & CO INC5 citations61
US4135978AJan 23, 1979
Production of n-acyl-thienamycins
MERCK & CO INC1 citations51
US4081548AMar 28, 1978
Antibiotics
MERCK & CO INC1 citations51
US4162193AJul 24, 1979
Enzymatic cleavage of N-acyl-thienamycins
MERCK & CO INC0 citations42