Inventor
EGHOLM MICHAEL
US42 patents
⚠️ This page may combine multiple inventors who share the name “EGHOLM MICHAEL”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
(unassigned)
17 patentsUS6395474B1May 28, 2002
Peptide nucleic acids
106 citations99
US5891625AApr 6, 1999
Use of nucleic acid analogues in the inhibition of nucleic acid amplification
236 citations98
US5773571AJun 30, 1998
Peptide nucleic acids
298 citations98
US5719262AFeb 17, 1998
Peptide nucleic acids having amino acid side chains
1,565 citations98
US5714331AFeb 3, 1998
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
1,692 citations98
US5539082AJul 23, 1996
Peptide nucleic acids
2,083 citations98
US6107470AAug 22, 2000
Histidine-containing peptide nucleic acids
99 citations97
US5736336AApr 7, 1998
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
258 citations97
US6357163B1Mar 19, 2002
Use of nucleic acid analogues in diagnostics and analytical procedures
72 citations96
US5972610AOct 26, 1999
Use of nucleic acid analogues in the inhibition of nucleic acid amplification
112 citations96
US5786461AJul 28, 1998
Peptide nucleic acids having amino acid side chains
207 citations96
US5766855AJun 16, 1998
Peptide nucleic acids having enhanced binding affinity and sequence specificity
151 citations96
US6228982B1May 8, 2001
Double-stranded peptide nucleic acids
74 citations93
US6713602B1Mar 30, 2004
Synthetic procedures for peptide nucleic acids
22 citations92
US6710163B1Mar 23, 2004
Peptide nucleic acid synthons
13 citations92
US6414112B1Jul 2, 2002
Peptide nucleic acids having 2,6-diaminopurine nucleobases
29 citations92
US6710164B1Mar 23, 2004
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
8 citations73
ISIS PHARMACEUTICALS INC
7 patentsUS5986053ANov 16, 1999
Peptide nucleic acids complexes of two peptide nucleic acid strands and one nucleic acid strand
ISIS PHARMACEUTICALS INC135 citations98
US7223833B1May 29, 2007
Peptide nucleic acid conjugates
ISIS PHARMACEUTICALS INC116 citations96
US5641625AJun 24, 1997
Cleaving double-stranded DNA with peptide nucleic acids
ISIS PHARMACEUTICALS INC63 citations95
US6613873B1Sep 2, 2003
Peptide nucleic acids having 2,6-diaminopurine nucleobases
ISIS PHARMACEUTICALS INC26 citations92
US6451968B1Sep 17, 2002
Peptide nucleic acids
ISIS PHARMACEUTICALS INC33 citations92
US6441130B1Aug 27, 2002
Linked peptide nucleic acids
ISIS PHARMACEUTICALS INC43 citations92
US6770738B1Aug 3, 2004
Higher order structure and binding of peptide nucleic acids
ISIS PHARMACEUTICALS INC8 citations73
APPLERA CORP
5 patentsUS6297016B1Oct 2, 2001
Template-dependent ligation with PNA-DNA chimeric probes
APPLERA CORP126 citations99
US6316230B1Nov 13, 2001
Polymerase extension at 3′ terminus of PNA-DNA chimera
APPLERA CORP130 citations98
US7057025B2Jun 6, 2006
Binary probe and clamp composition
APPLERA CORP13 citations84
US6887664B2May 3, 2005
Asynchronous primed PCR
APPLERA CORP15 citations84
US6787310B2Sep 7, 2004
Strand displacement methods employing competitor oligonucleotides for isolating one strand of a double-stranded nucleic acid
APPLERA CORP12 citations73
PE CORP NY
3 patentsUS6451588B1Sep 17, 2002
Multipartite high-affinity nucleic acid probes
PE CORP NY128 citations98
US6432642B1Aug 13, 2002
Binary probe and clamp composition and methods for a target hybridization detection
PE CORP NY48 citations96
US6331618B1Dec 18, 2001
Compositions of solvents and high concentrations of nucleic acid analogs
PE CORP NY16 citations78
PERSEPTIVE BIOSYSTEMS INC
2 patentsUS6133444AOct 17, 2000
Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
PERSEPTIVE BIOSYSTEMS INC42 citations90
US6172226B1Jan 9, 2001
Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
PERSEPTIVE BIOSYSTEMS INC21 citations88