Inventor
MATHRE DAVID J
US22 patents
Patents
22 patentsUS5336756AAug 9, 1994
Process for crystalline cyclic lipopeptides
MERCK & CO INC24 citations92
US5198421AMar 30, 1993
Phosphorylated cyclic lipopeptide
MERCK & CO INC34 citations92
US5883267AMar 16, 1999
Process for making phenyl heterocycles useful as cox-2 inhibitors
MERCK & CO INC23 citations91
US5157129AOct 20, 1992
Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
MERCK & CO INC23 citations90
US5189177AFeb 23, 1993
Chiral boron catalysts for reduction of ketones and process for their preparation
MERCK & CO INC19 citations81
US5039802AAug 13, 1991
Arylation process for preparation of chiral catalysts for ketone reduction
MERCK & CO INC20 citations81
US5688968ANov 18, 1997
Enantioselective synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno 2,3-B!thiopyran-2-sulfonamide 7,7-dioxide
MERCK & CO INC14 citations73
US5594134AJan 14, 1997
Process of synthesizing N-acyl auxiliaries
MERCK & CO INC8 citations73
US5461162AOct 24, 1995
Process of synthesizing n-acyl auxiliaries
MERCK & CO INC13 citations73
US5264585ANov 23, 1993
Chiral catalysts for reduction of ketones and process for their preparation
MERCK & CO INC15 citations73
US6153787ANov 28, 2000
Intermediates for making heterocycles useful as COX-2 inhibitors
MERCK & CO INC13 citations72
US5760249AJun 2, 1998
Synthesis of hydroxysulfone and related compounds
MERCK & CO INC15 citations71
US5264574ANov 23, 1993
Preparation of oxazaborolidine borane complex
MERCK & CO INC8 citations69
US5574176ANov 12, 1996
Synthesis of an intermediate for the preparation of 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h-thieno [2,3-b]thiopyran-2-sulfonamide 7,7-dioxide intermediates and related compounds
MERCK & CO INC7 citations68
US5777105AJul 7, 1998
Process for the preparation of imidazolyl macrolide immunosuppressants
MERCK & CO INC3 citations62
US4758661AJul 19, 1988
Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine
MERCK & CO INC3 citations62
US5233023AAug 3, 1993
Process for phosphate ester compounds of certain cyclohexapeptides
MERCK & CO INC2 citations61
US5773575AJun 30, 1998
Process for peptide segment condensation
MERCK & CO INC4 citations60
US5686607ANov 11, 1997
Pyridyl ethylation of lactam derivatives
MERCK & CO INC0 citations52
US5618934AApr 8, 1997
Boronic acid compound
MERCK & CO INC0 citations51
US5693805ADec 2, 1997
Process to derivatives of piperizinylcamphorsulfonyl oxytocin antagonists
MERCK & CO INC1 citations46
US5369093ANov 29, 1994
Lipopeptide derivatives
MERCK & CO INC0 citations42