Inventor
RATCLIFFE RONALD W
US72 patents
Patents
50 patentsUS6054434AApr 25, 2000
8a-azalides as veterinary antimicrobal agents
MERCK & CO INC59 citations92
US5756725AMay 26, 1998
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
MERCK & CO INC51 citations92
US5985844ANov 16, 1999
Homoerythromycin A derivatives modified at the 4"-and 8A-positions
MERCK & CO INC40 citations91
US6399597B1Jun 4, 2002
1,8-naphthosultamylmethyl carbapenem antibacterial compounds, compositions containing such compounds and methods treatment
MERCK & CO INC15 citations84
US7157604B2Jan 2, 2007
Selective estrogen receptor modulators
MERCK & CO INC20 citations82
US7087599B2Aug 8, 2006
Estrogen receptor modulators
MERCK & CO INC15 citations82
US4383946AMay 17, 1983
Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
MERCK & CO INC27 citations82
US4318912AMar 9, 1982
6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC20 citations82
US4309346AJan 5, 1982
Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
MERCK & CO INC24 citations82
US4273709AJun 16, 1981
Process for the preparation of thienamycin and intermediates
MERCK & CO INC21 citations82
US4226866AOct 7, 1980
Novel antibiotic analogues of cephalosporins
MERCK & CO INC22 citations82
US4217453AAug 12, 1980
6-Amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC25 citations82
US4174316ANov 13, 1979
4-Iodomethylazetidin-2-one
MERCK & CO INC17 citations82
US4290947ASep 22, 1981
Process for the preparation of thienamycin and intermediates
MERCK & CO INC23 citations78
US4833167AMay 23, 1989
2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
MERCK & CO INC7 citations74
US4820817AApr 11, 1989
Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid
MERCK & CO INC12 citations74
US4745188AMay 17, 1988
Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
MERCK & CO INC10 citations74
US4739048AApr 19, 1988
Process for the preparation of thienamycin and intermediates
MERCK & CO INC7 citations74
US4729993AMar 8, 1988
Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
MERCK & CO INC15 citations74
US4610823ASep 9, 1986
Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
MERCK & CO INC8 citations74
US4530841AJul 23, 1985
6- And 6,6-disubstituted-3-substituted amino-1-azabicyclo-[3.2.0]hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC10 citations74
US4424230AJan 3, 1984
6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo- 3.2.0!hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC16 citations74
US4378315AMar 29, 1983
Process for the preparation of thienamycin and intermediates
MERCK & CO INC6 citations74
US4310538AJan 12, 1982
3-Halo-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC11 citations74
US4298741ANov 3, 1981
6-Amido-3-substituted-1-azabicyclo[3.2.0]-hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC10 citations74
US4258040AMar 24, 1981
Cephalosporin compounds
MERCK & CO INC11 citations74
US4226870AOct 7, 1980
O-, N- and carboxyl derivatives of thienamycin
MERCK & CO INC13 citations74
US4032521AJun 28, 1977
Cephalosporin phosphonic acid, sulfonic acid and sulfonamide compounds
MERCK & CO INC16 citations74
US3962224AJun 8, 1976
Cephalosporin compounds
MERCK & CO INC9 citations74
US3947413AMar 30, 1976
3-α-Substituted cephalosporins
MERCK & CO INC7 citations74
US4675317AJun 23, 1987
2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
MERCK & CO INC12 citations73
US5496816AMar 5, 1996
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
MERCK & CO INC11 citations71
US4235922ANov 25, 1980
3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid
MERCK & CO INC13 citations67
US4957912ASep 18, 1990
7 acylamidocarbacephem antibacterial agents
MERCK & CO INC7 citations66
US4952397AAug 28, 1990
2-quaternary heteroarylalkylthio carbapenems having an acid moiety substituent
MERCK & CO INC3 citations63
US4892869AJan 9, 1990
2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids
MERCK & CO INC2 citations63
US4783453ANov 8, 1988
2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
MERCK & CO INC5 citations63
US4782051ANov 1, 1988
2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
MERCK & CO INC6 citations63
US4748162AMay 31, 1988
6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids
MERCK & CO INC4 citations63
US4736025AApr 5, 1988
Process for the preparation of thienamycin and intermediates
MERCK & CO INC2 citations63
US4707547ANov 17, 1987
Process for preparing carbapenem compounds
MERCK & CO INC4 citations63
US4650794AMar 17, 1987
6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
MERCK & CO INC6 citations63
US4610820ASep 9, 1986
Process for the preparation of thienamycin and intermediates
MERCK & CO INC4 citations63
US4400323AAug 23, 1983
3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one
MERCK & CO INC5 citations63
US4369187AJan 18, 1983
3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
MERCK & CO INC5 citations63
US4357342ANov 2, 1982
1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid
MERCK & CO INC2 citations63
US4275207AJun 23, 1981
Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
MERCK & CO INC6 citations63
US4211707AJul 8, 1980
Process for hydrolytically cleaving O-sulfo thienamycins
MERCK & CO INC4 citations63
US4150223AApr 17, 1979
Cephalosporin phosphonic acid, sulfonic acid and sulfonamide compounds
MERCK & CO INC4 citations63
US4086423AApr 25, 1978
Process for cephem synthesis
MERCK & CO INC3 citations63
Showing the top 50 of 72 patents by PatentIndex Score.