Inventor
GUINOSSO CHARLES JOHN
US11 patents
Patents
11 patentsUS5914396AJun 22, 1999
2'-O-modified nucleosides and phosphoramidites
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US5218105AJun 8, 1993
Polyamine conjugated oligonucleotides
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US5138045AAug 11, 1992
Polyamine conjugated oligonucleotides
ISIS PHARMACEUTICALS INC1,414 citations99
US7101993B1Sep 5, 2006
Oligonucleotides containing 2′-O-modified purines
ISIS PHARMACEUTICALS INC159 citations98
US6262241B1Jul 17, 2001
Compound for detecting and modulating RNA activity and gene expression
ISIS PHARMACEUTICALS INC190 citations96
US6156758ADec 5, 2000
Antibacterial quinazoline compounds
ISIS PHARMACEUTICALS INC68 citations96
US6358931B1Mar 19, 2002
Compositions and methods for modulating RNA
ISIS PHARMACEUTICALS INC75 citations95
US5856466AJan 5, 1999
Process for the preparation of 2'-O-alkyl purine phosphoramidites
ISIS PHARMACEUTICALS INC38 citations95
US6133438AOct 17, 2000
Process for the preparation of 2'-O-alkyl purine phosphoramidites
ISIS PHARMACEUTICALS INC20 citations92
US6610663B2Aug 26, 2003
Compositions and methods for modulating RNA
ISIS PHARMACEUTICALS INC4 citations62
US6242592B1Jun 5, 2001
Process for the preparation of 2′-O-alkyl-guanosine, cytidine, and uridine phosphoramidites
ISIS PHARMACEUTICALS INC0 citations51