Inventor

FROEHLER BRIAN C

US12 patents

⚠️ This page may combine multiple inventors who share the name “FROEHLER BRIAN C”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.

GILEAD SCIENCES INC

3 patents

US5565555AOct 15, 1996

Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues

GILEAD SCIENCES INC383 citations98

US5256775AOct 26, 1993

Exonuclease-resistant oligonucleotides

GILEAD SCIENCES INC928 citations98

US5194599AMar 16, 1993

Hydrogen phosphonodithioate compositions

GILEAD SCIENCES INC463 citations98

GENENTECH INC

3 patents

US5264566ANov 23, 1993

Method for in vitro oligonucleotide synthesis using H-phosphonates

GENENTECH INC174 citations98

US4959463ASep 25, 1990

Intermediates

GENENTECH INC164 citations98

US5548076AAug 20, 1996

Method of making oligonucleotides, oligonucleoside thiophosphates and oligonucleoside phosphotriesters using H-phosphonate intermediates

GENENTECH INC20 citations92

ISIS PHARMACEUTICALS INC

3 patents

US6495672B1Dec 17, 2002

Oligonucleotides including 2-aminopyridine and 2-pyridone C-nucleoside units

ISIS PHARMACEUTICALS INC11 citations73

US6447998B1Sep 10, 2002

2-Aminopyridine and 2-pyridone C-nucleosides, oligonucleotides comprising, and tests using the same oligonucleotides

ISIS PHARMACEUTICALS INC12 citations73

US6756496B1Jun 29, 2004

Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues

ISIS PHARMACEUTICALS INC3 citations62

FROEHLER BRIAN C

2 patents

US5204455AApr 20, 1993

Monomethoxytrityl protected oligonucleotides bound to a solid support

FROEHLER BRIAN C30 citations89

US8653248B2Feb 18, 2014

2-aminopyridine and 2-pyridone C-nucleosides

FROEHLER BRIAN C0 citations50

GILEAD SCIENCES

1 patent

US5164491ANov 17, 1992

Large scale synthesis of oligonucleotides and their associated analogs

GILEAD SCIENCES18 citations81