Inventor
SCHWITTER URS
CH22 patents
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HOFFMANN LA ROCHE
18 patentsUS11230559B2Jan 25, 2022
Solid forms of [(1 S)-1 -[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-D]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-Yl]proptl] acetate
HOFFMANN LA ROCHE4 citations71
US11040977B2Jun 22, 2021
Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crytalline forms thereof
HOFFMANN LA ROCHE1 citations70
US10246460B2Apr 2, 2019
Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof
HOFFMANN LA ROCHE2 citations70
US9676793B2Jun 13, 2017
Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
HOFFMANN LA ROCHE2 citations64
US12012421B2Jun 18, 2024
Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
HOFFMANN LA ROCHE0 citations60
US12012420B2Jun 18, 2024
Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
HOFFMANN LA ROCHE0 citations60
US7409041B2Aug 5, 2008
Methods of transmission mode X-ray diffraction analysis and apparatuses therefor
HOFFMANN LA ROCHE4 citations60
US12459947B2Nov 4, 2025
Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crystalline forms thereof
HOFFMANN LA ROCHE0 citations59
US12122789B2Oct 22, 2024
Forms of pyrido[1,2-a]pyrimidin-4-one derivatives, its formulation and its process of making
HOFFMANN LA ROCHE0 citations54
US10919041B2Feb 16, 2021
Preparing and analyzing solid form properties of a substance
HOFFMANN LA ROCHE0 citations53
US9562009B2Feb 7, 2017
Process to manufacture N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide
HOFFMANN LA ROCHE0 citations51
US7867452B2Jan 11, 2011
Multi-well filtration device
HOFFMANN LA ROCHE1 citations49
US10227298B2Mar 12, 2019
Solid forms of a pharmaceutically active compound
HOFFMANN LA ROCHE0 citations48
US8975397B2Mar 10, 2015
Solid forms
HOFFMANN LA ROCHE0 citations47
US8785435B2Jul 22, 2014
Solid forms
HOFFMANN LA ROCHE0 citations47
US7160881B2Jan 9, 2007
Crystalline modifications of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1 λ6-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide
HOFFMANN LA ROCHE0 citations47
US7772264B2Aug 10, 2010
Salt and polymorphs of a DPPIV inhibitor
HOFFMANN LA ROCHE0 citations46
US8039473B2Oct 18, 2011
Solid forms of [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone
HOFFMANN LA ROCHE1 citations43