Inventor

JOHNSTON DAVID B R

35 patents

Patents

35 patents

US5536716AJul 16, 1996

Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

MERCK & CO INC77 citations94

US4191759AMar 4, 1980

N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors

MERCK & CO INC53 citations94

US4255423AMar 10, 1981

Cephalosporin compounds

MERCK & CO INC38 citations92

US4442095AApr 10, 1984

N-[(5-Halo-2,6-(substituted)pyrazinyl)methylene]amine antimicrobial compounds, compositions and use

MERCK & CO INC21 citations82

US4234596ANov 18, 1980

3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

MERCK & CO INC26 citations82

US5389660AFeb 14, 1995

Substituted imidazo-fused 5-membered ring heterocycles as angiotensin II antagonists

MERCK & CO INC7 citations74

US5164407ANov 17, 1992

Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists

MERCK & CO INC6 citations74

US5157040AOct 20, 1992

Substituted quinolines as angiotensin ii antagonists

MERCK & CO INC9 citations74

US4997936AMar 5, 1991

2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids

MERCK & CO INC12 citations74

US4992542AFeb 12, 1991

2-substituted-6-carbadethiapen-2-em-3-carboxylic acids

MERCK & CO INC9 citations74

US4518599AMay 21, 1985

2-Amino-3-cyano-5-halo-6-(substituted)pyrazine

MERCK & CO INC9 citations74

US4517186AMay 14, 1985

2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds

MERCK & CO INC13 citations74

US4442096AApr 10, 1984

2-(Substituted)amino-3-cyano-5-halo-6-(substituted)-pyrazine antimicrobial compounds, compositions and use

MERCK & CO INC12 citations74

US4347367AAug 31, 1982

3-Substituted-6-(1'-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid

MERCK & CO INC8 citations74

US4347368AAug 31, 1982

3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

MERCK & CO INC10 citations74

US4296236AOct 20, 1981

7-(or 6-) Substituted-7-(or 6-)acylimino cephalosporin (or penicillin) compounds

MERCK & CO INC6 citations74

US4224336ASep 23, 1980

3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid

MERCK & CO INC9 citations74

US4218463AAug 19, 1980

3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

MERCK & CO INC17 citations74

US4179453ADec 18, 1979

Process for preparing 17β-carboxy-5-androsten-3-ones

MERCK & CO INC7 citations74

US4348320ASep 7, 1982

Substituted azetidiones

MERCK & CO INC11 citations71

US4512991AApr 23, 1985

3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds

MERCK & CO INC6 citations63

US4507299AMar 26, 1985

N-[2-amino-5-halo-6-(substituted)-3-pyrazinyl)-methylene]amine antimicrobial compounds

MERCK & CO INC4 citations63

US4481202ANov 6, 1984

2-Amino-3-carboxylate-5-halo-6-(substituted)pyrazine antimicrobial compounds

MERCK & CO INC3 citations63

US4281002AJul 28, 1981

3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid

MERCK & CO INC2 citations63

US4277482AJul 7, 1981

3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid s-oxides

MERCK & CO INC5 citations63

US4269873AMay 26, 1981

2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic acids

MERCK & CO INC3 citations63

US4390693AJun 28, 1983

Cephalosporin compounds

MERCK & CO INC4 citations62

US4442097AApr 10, 1984

3-Acyl-2-(substituted) amino-5-halo-6-(substituted) pyrazine antimicrobial compounds, compositions and use

MERCK & CO INC1 citations52

US4264621AApr 28, 1981

5-Substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

MERCK & CO INC1 citations52

US3943153AMar 9, 1976

(-)(Cis-1,2-epoxy propyl)phosphonic acid amides

MERCK & CO INC0 citations49

JOHNSTON DAVID B R

Patents

Spiro piperidines and homologs which promote release of growth hormone

4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors

Method of using spiro piperidines to promote the release of growth hormone

Spiro piperidines and homologs promote release of growth hormone

Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents

Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors

Cephalosporin compounds

N-[(5-Halo-2,6-(substituted)pyrazinyl)methylene]amine antimicrobial compounds, compositions and use

3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Substituted imidazo-fused 5-membered ring heterocycles as angiotensin II antagonists

Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists

Substituted quinolines as angiotensin ii antagonists

2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids

2-substituted-6-carbadethiapen-2-em-3-carboxylic acids

2-Amino-3-cyano-5-halo-6-(substituted)pyrazine

2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds

2-(Substituted)amino-3-cyano-5-halo-6-(substituted)-pyrazine antimicrobial compounds, compositions and use

3-Substituted-6-(1&#39;-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid

3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

7-(or 6-) Substituted-7-(or 6-)acylimino cephalosporin (or penicillin) compounds

3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid

3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Process for preparing 17β-carboxy-5-androsten-3-ones

Substituted azetidiones

3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds

N-[2-amino-5-halo-6-(substituted)-3-pyrazinyl)-methylene]amine antimicrobial compounds

2-Amino-3-carboxylate-5-halo-6-(substituted)pyrazine antimicrobial compounds

3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid

3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid s-oxides

2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic acids

Cephalosporin compounds

3-Acyl-2-(substituted) amino-5-halo-6-(substituted) pyrazine antimicrobial compounds, compositions and use

5-Substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

(-)(Cis-1,2-epoxy propyl)phosphonic acid amides

3-Substituted-6-(1'-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid