Inventor
VAN DER PLOEG LEONARDUS H T
US41 patents
⚠️ This page may combine multiple inventors who share the name “VAN DER PLOEG LEONARDUS H T”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
MERCK & CO INC
27 patentsUS6350760B1Feb 26, 2002
Substituted piperidines as melanocortin-4 receptor agonists
MERCK & CO INC102 citations97
US5824837AOct 20, 1998
Expression of human interleukin-1β in a transgenic animal
MERCK & CO INC150 citations97
US6410548B2Jun 25, 2002
Spiropiperidine derivatives as melanocortin receptor agonists
MERCK & CO INC71 citations96
US6294534B1Sep 25, 2001
Spiropiperidine derivatives as melanocortin receptor agonists
MERCK & CO INC75 citations96
US6211428B1Apr 3, 2001
Transgenic mouse expressing a familial form of human amyloid precursor protein
MERCK & CO INC165 citations94
US6187992B1Feb 13, 2001
Transgenic mouse having a disrupted amyloid precursor protein gene
MERCK & CO INC99 citations93
US6007998ADec 28, 1999
Leptin assay
MERCK & CO INC18 citations79
US6693184B1Feb 17, 2004
DNA molecules encoding splice variants of the human melanocortin 1 receptor protein
MERCK & CO INC12 citations73
US6573070B1Jun 3, 2003
DNA molecules encoding the melanocortin 4 receptor protein from rhesus monkey
MERCK & CO INC6 citations71
US5593864AJan 14, 1997
Process for functional expression of the para cation channel
MERCK & CO INC5 citations71
US7163799B2Jan 16, 2007
Neuromedin U receptor NMUR2 and nucleotides encoding it
MERCK & CO INC7 citations70
US6645738B1Nov 11, 2003
DNA molecules encoding the melanocortin 5 receptor protein from rhesus monkey
MERCK & CO INC6 citations70
US6639123B1Oct 28, 2003
Melanocortin-3 receptor deficient cells, non-human trangenic animals and methods of selecting compounds which regulate body weight
MERCK & CO INC10 citations70
US6242199B1Jun 5, 2001
Assays for growth hormone secretagogue receptors
MERCK & CO INC11 citations69
US6835548B2Dec 28, 2004
Isoforms of mouse serotonin 5-HT2c receptor
MERCK & CO INC6 citations68
US6531314B1Mar 11, 2003
Growth hormone secretagogue receptor family
MERCK & CO INC2 citations61
US6511827B1Jan 28, 2003
Nucleotide encoding human galanin receptor 3 (GALR3)
MERCK & CO INC5 citations61
US5550049AAug 27, 1996
Process for identifying para cation channel modulators
MERCK & CO INC1 citations61
US6452065B2Sep 17, 2002
Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background
MERCK & CO INC5 citations58
US6689873B1Feb 10, 2004
Nucleic acid encoding rat agouti related protein
MERCK & CO INC4 citations55
US7001734B1Feb 21, 2006
Process for identifying para cation channel modulators
MERCK & CO INC1 citations51
US6495665B1Dec 17, 2002
Isoforms of mouse serotonin 5-HT2C receptor
MERCK & CO INC1 citations51
US7029865B2Apr 18, 2006
DNA molecules encoding the melanocortin 4 receptor protein from rhesus monkey
MERCK & CO INC0 citations50
US5688917ANov 18, 1997
Process for functional expression of the para cation channel
MERCK & CO INC1 citations49
US7321074B1Jan 22, 2008
Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight
MERCK & CO INC1 citations48
US6878520B1Apr 12, 2005
C-terminal region of agouti-related transcript (ART) protein
MERCK & CO INC0 citations48
US6682908B1Jan 27, 2004
Mouse growth hormone secretagogue receptor
MERCK & CO INC1 citations47
RHYTHM PHARMACEUTICALS INC
8 patentsUS11129869B2Sep 28, 2021
Pharmaceutical compositions
RHYTHM PHARMACEUTICALS INC5 citations82
US10196425B2Feb 5, 2019
Peptide compositions
RHYTHM PHARMACEUTICALS INC7 citations82
US10954268B2Mar 23, 2021
Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
RHYTHM PHARMACEUTICALS INC1 citations72
US10858399B2Dec 8, 2020
Peptide compositions
RHYTHM PHARMACEUTICALS INC2 citations71
US12077612B2Sep 3, 2024
Peptide compositions
RHYTHM PHARMACEUTICALS INC0 citations61
US11702448B2Jul 18, 2023
Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
RHYTHM PHARMACEUTICALS INC0 citations61
US12285460B2Apr 29, 2025
Pharmaceutical compositions
RHYTHM PHARMACEUTICALS INC1 citations57
US10960046B2Mar 30, 2021
Method of treating melanocortin-4 receptor pathway-associated disorders
RHYTHM PHARMACEUTICALS INC0 citations55
DEUTERX LLC
2 patentsUS9732031B2Aug 15, 2017
Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion
DEUTERX LLC121 citations97
US10188639B2Jan 29, 2019
Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
DEUTERX LLC3 citations72