Inventor
MCKEARN JOHN P
US31 patents
⚠️ This page may combine multiple inventors who share the name “MCKEARN JOHN P”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
SEARLE & CO
24 patentsUS6858598B1Feb 22, 2005
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
SEARLE & CO97 citations96
US6440407B1Aug 27, 2002
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides
SEARLE & CO37 citations96
US6030812AFeb 29, 2000
Fusion proteins comprising multiply mutated interleukin-3 (IL-3) polypeptides and second growth factors
SEARLE & CO47 citations96
US6833373B1Dec 21, 2004
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
SEARLE & CO64 citations95
US6060047AMay 9, 2000
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
SEARLE & CO16 citations92
US5738849AApr 14, 1998
Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
SEARLE & CO23 citations92
US6689787B1Feb 10, 2004
Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia
SEARLE & CO33 citations91
US6066318AMay 23, 2000
Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
SEARLE & CO22 citations91
US6022535AFeb 8, 2000
Treatment of hematopoietic disorders with fusion proteins comprising multiply mutated interleukin-3 (IL-3) polypeptides and second growth factors
SEARLE & CO21 citations91
US6100070AAug 8, 2000
G-CSF receptor agonists
SEARLE & CO35 citations89
US5604116AFeb 18, 1997
Interleukin-3 (IL-3) multiple mutation polypeptides, recombinant production of the same, and corresponding therapeutic methods
SEARLE & CO20 citations89
US6436387B1Aug 20, 2002
Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
SEARLE & CO19 citations84
US6153183ANov 28, 2000
Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
SEARLE & CO15 citations82
US6093395AJul 25, 2000
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
SEARLE & CO14 citations82
US6051217AApr 18, 2000
Therapeutic uses of interleukin-3 (IL-3) multiple mutation polypeptides
SEARLE & CO15 citations82
US6265439B1Jul 24, 2001
Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
SEARLE & CO7 citations74
US5451604ASep 19, 1995
Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
SEARLE & CO11 citations74
US5247119ASep 21, 1993
Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
SEARLE & CO10 citations73
US6451852B2Sep 17, 2002
Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
SEARLE & CO7 citations72
US5543141AAug 6, 1996
Therapeutic methods using interleukin-3 (IL-3) human/murine hybrid polypeptides
SEARLE & CO5 citations72
US5501962AMar 26, 1996
Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
SEARLE & CO9 citations72
US5486539AJan 23, 1996
Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
SEARLE & CO8 citations72
US5162569ANov 10, 1992
Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
SEARLE & CO9 citations72
US6254870B1Jul 3, 2001
Thrombopoietin: IL-3 fusion protein
SEARLE & CO7 citations55
(unassigned)
4 patentsUS6361977B1Mar 26, 2002
Methods of using multivariant IL-3 hematopoiesis fusion protein
33 citations92
US6413509B1Jul 2, 2002
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
3 citations63
US6379662B1Apr 30, 2002
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
2 citations53
US6361976B1Mar 26, 2002
Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
2 citations52