Inventor
COMINS DANIEL L
US41 patents
⚠️ This page may combine multiple inventors who share the name “COMINS DANIEL L”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
UNIV NORTH CAROLINA STATE
34 patentsUS5162532ANov 10, 1992
Intermediates and method of making camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE54 citations96
US6995265B2Feb 7, 2006
Synthesis of nicotine derivatives from nicotine
UNIV NORTH CAROLINA STATE36 citations95
US5321140AJun 14, 1994
Pyridinecarboxaldehyde D-ring intermediates useful for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE28 citations92
US5247089ASep 21, 1993
Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE28 citations92
US5243050ASep 7, 1993
Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE22 citations92
US5200524AApr 6, 1993
Camptothecin intermediates and method of making same
UNIV NORTH CAROLINA STATE29 citations92
US5191082AMar 2, 1993
Camptothecin intermediate and method of making camptothecin intermediates
UNIV NORTH CAROLINA STATE34 citations92
US5475108ADec 12, 1995
Camptothecin intermediates and method of making camptothecin and comptothecin analogs
UNIV NORTH CAROLINA STATE9 citations74
US5459269AOct 17, 1995
14-halo-camptothecins
UNIV NORTH CAROLINA STATE17 citations74
US5315007AMay 24, 1994
Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE8 citations74
US5264579ANov 23, 1993
D ring intermediates for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE6 citations74
US5254690AOct 19, 1993
Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs
UNIV NORTH CAROLINA STATE6 citations74
US5212317AMay 18, 1993
Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE14 citations74
US7132545B2Nov 7, 2006
Synthesis of nicotine derivatives from nicotine
UNIV NORTH CAROLINA STATE9 citations73
US7179917B2Feb 20, 2007
Regioselective halogenation of nicotine and substituted nicotines
UNIV NORTH CAROLINA STATE4 citations71
US7067672B2Jun 27, 2006
Regioselective halogenation of nicotine and substituted nicotines
UNIV NORTH CAROLINA STATE7 citations71
US7304160B2Dec 4, 2007
Regiospecific synthesis of nicotine derivatives
UNIV NORTH CAROLINA STATE4 citations69
US5496952AMar 5, 1996
Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE2 citations63
US5428166AJun 27, 1995
Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE4 citations63
US5395939AMar 7, 1995
Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
UNIV NORTH CAROLINA STATE4 citations63
US7361768B2Apr 22, 2008
Synthesis of nicotine derivatives from nicotine
UNIV NORTH CAROLINA STATE2 citations62
US7112678B2Sep 26, 2006
Regiospecific synthesis of nicotine derivatives
UNIV NORTH CAROLINA STATE3 citations58
US5262571ANov 16, 1993
Cycloalkyl-based chiral auxiliaries and method making the same
UNIV NORTH CAROLINA STATE4 citations54
US6987189B2Jan 17, 2006
Short synthesis of pyridine-based pharmaceutical intermediates
UNIV NORTH CAROLINA STATE0 citations52
US6855825B2Feb 15, 2005
Short synthesis of pyridine-based pharmaceutical intermediates
UNIV NORTH CAROLINA STATE0 citations52
US6706884B2Mar 16, 2004
Short synthesis of pyridine-based pharmaceutical intermediates
UNIV NORTH CAROLINA STATE0 citations52
US6534656B2Mar 18, 2003
Short synthesis of pyridine-based pharmaceutical intermediates
UNIV NORTH CAROLINA STATE0 citations52
US5486615AJan 23, 1996
Method of making asymmetric DE ring intermediates for the synthesis of camptothecin analogs
UNIV NORTH CAROLINA STATE0 citations52
US5478943ADec 26, 1995
Method of making intermediates for camptothecin and its analogs
UNIV NORTH CAROLINA STATE1 citations52
US7888512B2Feb 15, 2011
Synthesis of nicotine derivatives from nicotine
UNIV NORTH CAROLINA STATE0 citations51
US7553968B2Jun 30, 2009
Synthesis of nicotine derivatives from nicotine
UNIV NORTH CAROLINA STATE0 citations51
US7875724B2Jan 25, 2011
Regiospecific synthesis of nicotine derivatives
UNIV NORTH CAROLINA STATE0 citations48
US7671209B2Mar 2, 2010
Regiospecific synthesis of nicotine derivatives
UNIV NORTH CAROLINA STATE0 citations48
US7820826B2Oct 26, 2010
Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives
UNIV NORTH CAROLINA STATE0 citations46
OSI PHARM INC
3 patentsUS6462196B1Oct 8, 2002
Preparation of a camptothecin derivative by intramolecular cyclization
OSI PHARM INC1 citations60
US6821982B2Nov 23, 2004
Preparation of a camptothecin derivative by intramolecular cyclisation
OSI PHARM INC0 citations50
US6559309B2May 6, 2003
Preparation of a camptothecin derivative by intramolecular cyclisation
OSI PHARM INC0 citations50