Inventor
KLEINSTIVER BENJAMIN
US29 patents
Patents
29 patentsUS9512446B1Dec 6, 2016
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL164 citations99
US9944912B2Apr 17, 2018
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL25 citations98
US9926546B2Mar 27, 2018
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL52 citations98
US9752132B2Sep 5, 2017
Engineered CRISPR-CAS9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL48 citations98
US10633642B2Apr 28, 2020
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL12 citations94
US10526591B2Jan 7, 2020
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL19 citations94
US10093910B2Oct 9, 2018
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL26 citations94
US9926545B2Mar 27, 2018
Engineered CRISPR-CAS9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL18 citations94
US10202589B2Feb 12, 2019
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL10 citations92
US12241096B2Mar 4, 2025
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL4 citations86
US10808233B2Oct 20, 2020
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL3 citations84
US10767168B2Sep 8, 2020
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL7 citations84
US10479982B2Nov 19, 2019
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL5 citations84
US11286468B2Mar 29, 2022
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL2 citations73
US11220678B2Jan 11, 2022
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL2 citations73
US11168313B2Nov 9, 2021
Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
MASSACHUSETTS GEN HOSPITAL2 citations73
US11060078B2Jul 13, 2021
Engineered CRISPR-Cas9 nucleases
MASSACHUSETTS GEN HOSPITAL2 citations73
US11667677B2Jun 6, 2023
Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1
MASSACHUSETTS GEN HOSPITAL3 citations69
US12590299B2Mar 31, 2026
Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
MASSACHUSETTS GEN HOSPITAL0 citations62
US12180520B2Dec 31, 2024
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL0 citations62
US11859220B2Jan 2, 2024
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL0 citations62
US11624058B2Apr 11, 2023
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL0 citations62
US12286641B2Apr 29, 2025
Methods for increasing efficiency of nuclease-induced homology-directed repair
MASSACHUSETTS GEN HOSPITAL0 citations59
US12202861B2Jan 21, 2025
Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1
MASSACHUSETTS GEN HOSPITAL0 citations59
US11021718B2Jun 1, 2021
Methods for increasing efficiency of nuclease-induced homology-directed repair
MASSACHUSETTS GEN HOSPITAL0 citations59
US12173339B2Dec 24, 2024
Variants of Cpf1 (Cas12a) with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL0 citations58
US11591589B2Feb 28, 2023
Variants of Cpf1 (Cas12a) with altered PAM specificity
MASSACHUSETTS GEN HOSPITAL1 citations58
US12312613B2May 27, 2025
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
MASSACHUSETTS GEN HOSPITAL1 citations56
US12264341B2Apr 1, 2025
CRISPR-Cas enzymes with enhanced on-target activity
MASSACHUSETTS GEN HOSPITAL0 citations44