Inventor

CRAGOE JR EDWARD J

157 patents

Patents

50 patents

US4375475AMar 1, 1983

4-[5(and 4)-Substituted-2-thienyl]-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

MERCK & CO INC104 citations96

US4342776AAug 3, 1982

4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

MERCK & CO INC57 citations96

US4317822AMar 2, 1982

3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-triazin-2-yl)2-pyrazinecarboxamides

MERCK & CO INC50 citations96

US4296122AOct 20, 1981

2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids

MERCK & CO INC59 citations96

US4282365AAug 4, 1981

Dibenz[b,e]oxepin compounds

MERCK & CO INC56 citations96

US4263207AApr 21, 1981

10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof

MERCK & CO INC55 citations96

US4237144ADec 2, 1980

2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans

MERCK & CO INC52 citations96

US4237130ADec 2, 1980

2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids

MERCK & CO INC56 citations96

US4225609ASep 30, 1980

Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids

MERCK & CO INC48 citations96

US4140776AFeb 20, 1979

N-pyrazinecarbonyl-N'-acylguanidines

MERCK & CO INC52 citations96

US4096267AJun 20, 1978

(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof

MERCK & CO INC55 citations96

US4087542AMay 2, 1978

2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

MERCK & CO INC59 citations96

US4085219AApr 18, 1978

1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

MERCK & CO INC55 citations96

US4085117AApr 18, 1978

6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids

MERCK & CO INC56 citations96

US4070539AJan 24, 1978

[1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid

MERCK & CO INC56 citations96

US4012524AMar 15, 1977

[1-Hydroxy-5-indanyloxy (or thio)]-alkanoic acids

MERCK & CO INC63 citations96

US4006180AFeb 1, 1977

[1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids

MERCK & CO INC59 citations96

US3991106ANov 9, 1976

16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins

MERCK & CO INC57 citations96

US3987091AOct 19, 1976

11,12-secoprostaglandins

MERCK & CO INC59 citations96

US3984465AOct 5, 1976

1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

MERCK & CO INC58 citations96

US3956374AMay 11, 1976

Aryl-oxo-heptenoic acids

MERCK & CO INC56 citations96

US3953476AApr 27, 1976

3-Amino-5-sulfonylbenzoic acids

MERCK & CO INC62 citations96

US3931239AJan 6, 1976

6-Oxo-7-substituted-6H-indeno-[5,4-b]furan(and thiophene)-carboxylic acids

MERCK & CO INC58 citations96

US4246406AJan 20, 1981

Heterocyclic substituted pyrazinoylguanidines

MERCK & CO INC60 citations95

US4085211AApr 18, 1978

Pyrazinecarboxamides and processes for preparing same

MERCK & CO INC81 citations95

US4775695AOct 4, 1988

Substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof

MERCK & CO INC27 citations93

US4675341AJun 23, 1987

[(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol and its derivatives

MERCK & CO INC27 citations93

US4654365AMar 31, 1987

2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury

MERCK & CO INC32 citations93

US4634717AJan 6, 1987

Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, useful for treating persons with gray matter edema

MERCK & CO INC32 citations93

US4605663AAug 12, 1986

Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, for treatment of grey matter edema

MERCK & CO INC26 citations93

US4605664AAug 12, 1986

Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treatment of grey matter edema

MERCK & CO INC27 citations93

US4604396AAug 5, 1986

[(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts

MERCK & CO INC32 citations93

US4604403AAug 5, 1986

Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema

MERCK & CO INC26 citations93

US4596821AJun 24, 1986

Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones

MERCK & CO INC28 citations93

US4579869AApr 1, 1986

Substituted [(2,3-dihydro-1-oxo-1H-inden-5-yl)amino]alkanoic acids, their derivatives and their salts

MERCK & CO INC39 citations93

US4537902AAug 27, 1985

4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

MERCK & CO INC33 citations93

US4465850AAug 14, 1984

Treatment of brain injury due to gray matter edema with (indanyloxy) butanoic acids

MERCK & CO INC38 citations93

US4431660AFeb 14, 1984

(4'-Biphenylyloxy and-thio-oxy)-3-hydroxy-3-pyrroline-2,5-diones and a method of treating calcium oxalate renal lithiasis therewith

MERCK & CO INC35 citations93

US4431652AFeb 14, 1984

4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis

MERCK & CO INC34 citations93

US4428959AJan 31, 1984

4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

MERCK & CO INC32 citations93

US4428956AJan 31, 1984

4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis

MERCK & CO INC42 citations93

US4401669AAug 30, 1983

2,3-Dihydro-substituted-5-benzoyl benzofuran-2-carboxylic acids and their use in treating hypertension

MERCK & CO INC45 citations93

US4394385AJul 19, 1983

Treatment of gray matter edema

MERCK & CO INC35 citations93

US4379791AApr 12, 1983

4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

MERCK & CO INC35 citations93

Showing the top 50 of 157 patents by PatentIndex Score.

CRAGOE JR EDWARD J

Patents

Substituted pyranone inhibitors of cholesterol synthesis

Compounds useful in treating sickle cell anemia

Method of treating a person for sickle cell anemia

Compounds useful in treating sickle cell anemia

Compounds useful in treating sickle cell anemia

Substituted pyranone inhibitors of cholesterol synthesis

4-[5(and 4)-Substituted-2-thienyl]-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-triazin-2-yl)2-pyrazinecarboxamides

2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids

Dibenz[b,e]oxepin compounds

10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof

2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans

2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids

Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids

N-pyrazinecarbonyl-N&#39;-acylguanidines

(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof

2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids

[1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid

[1-Hydroxy-5-indanyloxy (or thio)]-alkanoic acids

[1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids

16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins

11,12-secoprostaglandins

1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

Aryl-oxo-heptenoic acids

3-Amino-5-sulfonylbenzoic acids

6-Oxo-7-substituted-6H-indeno-[5,4-b]furan(and thiophene)-carboxylic acids

Heterocyclic substituted pyrazinoylguanidines

Pyrazinecarboxamides and processes for preparing same

Substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof

[(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol and its derivatives

2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury

Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, useful for treating persons with gray matter edema

Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, for treatment of grey matter edema

Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treatment of grey matter edema

[(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts

Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema

Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones

Substituted [(2,3-dihydro-1-oxo-1H-inden-5-yl)amino]alkanoic acids, their derivatives and their salts

4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

Treatment of brain injury due to gray matter edema with (indanyloxy) butanoic acids

(4&#39;-Biphenylyloxy and-thio-oxy)-3-hydroxy-3-pyrroline-2,5-diones and a method of treating calcium oxalate renal lithiasis therewith

4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis

4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis

2,3-Dihydro-substituted-5-benzoyl benzofuran-2-carboxylic acids and their use in treating hypertension

Treatment of gray matter edema

4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase

N-pyrazinecarbonyl-N'-acylguanidines

(4'-Biphenylyloxy and-thio-oxy)-3-hydroxy-3-pyrroline-2,5-diones and a method of treating calcium oxalate renal lithiasis therewith