Inventor

STOKKER GERALD E

46 patents

Patents

46 patents

US6063930AMay 16, 2000

Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors

MERCK & CO INC114 citations98

US6080870AJun 27, 2000

Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors

MERCK & CO INC105 citations97

US5710171AJan 20, 1998

[5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives

MERCK & CO INC37 citations92

US4356313AOct 26, 1982

[(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts

MERCK & CO INC38 citations92

US4337354AJun 29, 1982

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives

MERCK & CO INC37 citations92

US4317922AMar 2, 1982

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives

MERCK & CO INC47 citations92

US4316043AFeb 16, 1982

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives

MERCK & CO INC52 citations92

US4159279AJun 26, 1979

Nuclear substituted 2-hydroxyphenylmethanesulfamic acids

MERCK & CO INC45 citations92

US4092414AMay 30, 1978

3,4-Dihydrospiro-2H-1,3-benzoxazines and their use in treating edema, abnormal electrolyte retention, and inflammation

MERCK & CO INC50 citations92

US4067980AJan 10, 1978

Spirobenzoxazinium salts, method of use and compositions thereof as antihypertensive agents

MERCK & CO INC50 citations92

US4003927AJan 18, 1977

(1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-yloxy) acetic acids and derivatives

MERCK & CO INC49 citations92

US6284755B1Sep 4, 2001

Inhibitors of prenyl-protein transferase

MERCK & CO INC16 citations84

USRE36481EJan 4, 2000

HMG-CoA reductase inhibitors

MERCK & CO INC17 citations84

US6358985B1Mar 19, 2002

Inhibitors of prenyl-protein transferase

MERCK & CO INC21 citations83

US4308378ADec 29, 1981

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

MERCK & CO INC20 citations82

US4221790ASep 9, 1980

Substituted 2,2-dioxo-1,2,3-benzoxathiazines

MERCK & CO INC20 citations82

US4166177AAug 28, 1979

Substituted 2,2-dioxo-1,2,3-benzoxathiazines

MERCK & CO INC25 citations82

US4156005AMay 22, 1979

Derivatives of 1,2-benzisoxazoles

MERCK & CO INC28 citations82

US6566385B2May 20, 2003

Inhibitors of prenyl-protein transferase

MERCK & CO INC8 citations74

US5523456AJun 4, 1996

Inhibitors of farnesyl-protein transferase

MERCK & CO INC11 citations74

US5362906ANov 8, 1994

Farnesyl pyrophosphate analogs

MERCK & CO INC8 citations74

US5298655AMar 29, 1994

Farnesyl pyrophosphate analogs

MERCK & CO INC6 citations74

US4772626ASep 20, 1988

Antihypercholesterolemic compounds

MERCK & CO INC15 citations74

US6358956B1Mar 19, 2002

Inhibitors of prenyl-protein transferase

MERCK & CO INC8 citations73

US4123537AOct 31, 1978

2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in treating hypertension and edema

MERCK & CO INC6 citations71

US5652257AJul 29, 1997

Heterocycle-containing inhibitors of farnesyl-protein transferase

MERCK & CO INC3 citations63

US4902709AFeb 20, 1990

Novel antihypercholesterolemic compounds

MERCK & CO INC2 citations63

US4855321AAug 8, 1989

Antihypercholesterolemic compounds

MERCK & CO INC4 citations63

US4789682ADec 6, 1988

Antihypercholesterolemic compounds

MERCK & CO INC2 citations63

US4588820AMay 13, 1986

Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one

MERCK & CO INC3 citations63

US5041562AAug 20, 1991

3-keto HMG-CoA reductase inhibitors

MERCK & CO INC1 citations52

US4113877ASep 12, 1978

Substituted 2-aminomethylphenyl sulfamates

MERCK & CO INC1 citations52

US5576293ANov 19, 1996

Inhibitors of farnesyl-protein transferase

MERCK & CO INC1 citations50

US5053525AOct 1, 1991

Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents

MERCK & CO INC0 citations42

US5001241AMar 19, 1991

3-KETO HMG-CoA reductase inhibitors

MERCK & CO INC0 citations42

STOKKER GERALD E

Patents

Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors

Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors

Bisphenyl inhibitors of farnesyl-protein transferase

Inhibitors of farnesyl-protein transferase

Inhibitors of farnesyl-protein transferase

HMG-CoA reductase inhibitors

Novel HMG-CoA reductase inhibitors

Inhibitors of farnesyl-protein transferase

Inhibitors of prenyl-protein transferase

HMG-CoA reductase inhibitors

Inhibitors of farnesyl-protein transferase

3-keto HMG-CoA reductase inhibitors

3-keto HMG-COA reductase inhibitors

[5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives

[(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives

[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives

Nuclear substituted 2-hydroxyphenylmethanesulfamic acids

3,4-Dihydrospiro-2H-1,3-benzoxazines and their use in treating edema, abnormal electrolyte retention, and inflammation

Spirobenzoxazinium salts, method of use and compositions thereof as antihypertensive agents

(1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-yloxy) acetic acids and derivatives

Inhibitors of prenyl-protein transferase

HMG-CoA reductase inhibitors

Inhibitors of prenyl-protein transferase

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

Substituted 2,2-dioxo-1,2,3-benzoxathiazines

Substituted 2,2-dioxo-1,2,3-benzoxathiazines

Derivatives of 1,2-benzisoxazoles

Inhibitors of prenyl-protein transferase

Inhibitors of farnesyl-protein transferase

Farnesyl pyrophosphate analogs

Farnesyl pyrophosphate analogs

Antihypercholesterolemic compounds

Inhibitors of prenyl-protein transferase

2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in treating hypertension and edema

Heterocycle-containing inhibitors of farnesyl-protein transferase

Novel antihypercholesterolemic compounds

Antihypercholesterolemic compounds

Antihypercholesterolemic compounds

Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one

3-keto HMG-CoA reductase inhibitors

Substituted 2-aminomethylphenyl sulfamates

Inhibitors of farnesyl-protein transferase

Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents

3-KETO HMG-CoA reductase inhibitors