Inventor

TOMCUFCIK ANDREW S

51 patents

Patents

50 patents

US4626538ADec 2, 1986

[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines

AMERICAN CYANAMID CO106 citations96

US4521422AJun 4, 1985

Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones

AMERICAN CYANAMID CO71 citations96

US6399621B1Jun 4, 2002

N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

AMERICAN CYANAMID CO78 citations95

US5538977AJul 23, 1996

3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines

AMERICAN CYANAMID CO19 citations93

US4900836AFeb 13, 1990

(3-amino-1H-pyrazol-4-yl) (aryl)methanones

AMERICAN CYANAMID CO38 citations93

US4654347AMar 31, 1987

Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones

AMERICAN CYANAMID CO43 citations93

US4576943AMar 18, 1986

N-[ω(3-pyridinyl)alkyl]benzamides, useful as thromboxane synthetase enzyme and/or cardioprotective agents

AMERICAN CYANAMID CO7 citations74

US4710502ADec 1, 1987

3-heteroarylalkyl-4-quinazolinones

AMERICAN CYANAMID CO15 citations74

US4568685AFeb 4, 1986

N-[(1H-1,2,4-Triazol-1-yl)alkyl]-arylamides

AMERICAN CYANAMID CO13 citations74

US4542145ASep 17, 1985

Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides

AMERICAN CYANAMID CO7 citations74

US5079247AJan 7, 1992

N1 -substituted benz(cd)indol-2-imine compounds as cardiovascular agents

AMERICAN CYANAMID CO15 citations73

US4562189ADec 31, 1985

Pyrazolylpiperazines

AMERICAN CYANAMID CO17 citations73

US4347248AAug 31, 1982

2,3-Disubstituted-thiazolo[3,2-a]pyrimidines

AMERICAN CYANAMID CO6 citations73

US4269832AMay 26, 1981

Method of treating arthritic disease

AMERICAN CYANAMID CO18 citations73

US4262122AApr 14, 1981

Preparation of 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydro-pyrimidine hydrohalide

AMERICAN CYANAMID CO17 citations73

US4261892AApr 14, 1981

2,4,6-Tris-(substituted-amino)-s-triazines

AMERICAN CYANAMID CO9 citations73

US5081131AJan 14, 1992

Omega-((hetero)alkyl)benz(cd)-indol-2-amines

AMERICAN CYANAMID CO13 citations72

US4977189ADec 11, 1990

Substituted guanidinedicarbonyl derivatives

AMERICAN CYANAMID CO18 citations72

US4732895AMar 22, 1988

α-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-piperazineethanols useful for treating hypertension

AMERICAN CYANAMID CO8 citations72

US4261896AApr 14, 1981

1-Substituted-2-(substituted-imino)-1H-1,2-dihydrobenz[cd]indoles

AMERICAN CYANAMID CO10 citations71

US4892885AJan 9, 1990

Esters of (triarylphosphoranylidene)carbamic acid for effecting diuresis

AMERICAN CYANAMID CO2 citations63

US4753944AJun 28, 1988

Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones

AMERICAN CYANAMID CO4 citations63

US4289769ASep 15, 1981

Derivatives of p-formylbenzamide amidinohydrazone and use thereof

AMERICAN CYANAMID CO2 citations63

US4782064ANov 1, 1988

2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

AMERICAN CYANAMID CO5 citations62

US4680293AJul 14, 1987

3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzotriazin-4(3H)-ones and derivatives thereof

AMERICAN CYANAMID CO5 citations62

US4344954AAug 17, 1982

2,3-Disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols

AMERICAN CYANAMID CO2 citations62

US4283334AAug 11, 1981

2,3-Disubstituted-2,3,6,7,8,9-hexahydro-5H-thiazolo[3,2-a]-[1,3]diazocin-3-ols

AMERICAN CYANAMID CO2 citations62

US4829089AMay 9, 1989

Substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents

AMERICAN CYANAMID CO3 citations61

US4728663AMar 1, 1988

N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme

AMERICAN CYANAMID CO4 citations61

US4686220AAug 11, 1987

Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals

AMERICAN CYANAMID CO5 citations61

US4914234AApr 3, 1990

10,10-Dihydro-10-((substituted-carbonyl)imino)-10-phenyl-10H-phenoxaphosphine, hydrochloride

AMERICAN CYANAMID CO2 citations60

US4200748AApr 29, 1980

Pyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxalines and pyrrolo[1',2':4,5][1,4]oxazino[2,3-b]quinoxalines

AMERICAN CYANAMID CO2 citations58

US4325955AApr 20, 1982

Substituted 3-benzhydrylthiazolo(3,2-a)pyrimidines

AMERICAN CYANAMID CO2 citations57

US5229411AJul 20, 1993

Substituted benz[cd]indol-2-(1H)-ones and use as antihypertensive agents

AMERICAN CYANAMID CO1 citations51

US4393004AJul 12, 1983

3-[(α-Substituted-benzyl]-2,3,dihydrothiazolo[3,2-a][1,3]diazacyclan-3-ol derivatives

AMERICAN CYANAMID CO0 citations51

US4377589AMar 22, 1983

Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols

AMERICAN CYANAMID CO1 citations51

US4368335AJan 11, 1983

N'-(2,6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines

AMERICAN CYANAMID CO1 citations51

US4360466ANov 23, 1982

N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylformamidines

AMERICAN CYANAMID CO0 citations51

US4777290AOct 11, 1988

10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phenyl-10H-phenoxaphosphines

AMERICAN CYANAMID CO1 citations50

US4771061ASep 13, 1988

Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation

AMERICAN CYANAMID CO1 citations50

US4689324AAug 25, 1987

10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phenyl-10H-phenoxaphosphines compositions containing same and therapeutic methods of use

AMERICAN CYANAMID CO1 citations50

US4259490AMar 31, 1981

2-(Substituted amino)benz[cd]indoles

AMERICAN CYANAMID CO1 citations49

US4894368AJan 16, 1990

Certain triphenylphosphinimide derivatives

AMERICAN CYANAMID CO1 citations47

US4767749AAug 30, 1988

Ester of (triarylphosphoranylidene)carbamic acid having diuretic and ability to lower plasma renin properties

AMERICAN CYANAMID CO0 citations47

Showing the top 50 of 51 patents by PatentIndex Score.

TOMCUFCIK ANDREW S

Patents

[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines

Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones

N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines

(3-amino-1H-pyrazol-4-yl) (aryl)methanones

Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones

Pyrazolo[1,5-a]pyrimidines

2-(Pyridyl)imidazolyl ketones

3-heteroalkyl-2,4-quinzaolinediones

2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines

1-(5-Amino-4H-1,2,4-triazol-3-yl)-4-substituted-piperazines

Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones

N-[ω(3-pyridinyl)alkyl]benzamides, useful as thromboxane synthetase enzyme and/or cardioprotective agents

3-heteroarylalkyl-4-quinazolinones

N-[(1H-1,2,4-Triazol-1-yl)alkyl]-arylamides

Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides

N1 -substituted benz(cd)indol-2-imine compounds as cardiovascular agents

Pyrazolylpiperazines

2,3-Disubstituted-thiazolo[3,2-a]pyrimidines

Method of treating arthritic disease

Preparation of 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydro-pyrimidine hydrohalide

2,4,6-Tris-(substituted-amino)-s-triazines

Omega-((hetero)alkyl)benz(cd)-indol-2-amines

Substituted guanidinedicarbonyl derivatives

α-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-piperazineethanols useful for treating hypertension

1-Substituted-2-(substituted-imino)-1H-1,2-dihydrobenz[cd]indoles

Esters of (triarylphosphoranylidene)carbamic acid for effecting diuresis

Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones

Derivatives of p-formylbenzamide amidinohydrazone and use thereof

2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzotriazin-4(3H)-ones and derivatives thereof

2,3-Disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols

2,3-Disubstituted-2,3,6,7,8,9-hexahydro-5H-thiazolo[3,2-a]-[1,3]diazocin-3-ols

Substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents

N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme

Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals

10,10-Dihydro-10-((substituted-carbonyl)imino)-10-phenyl-10H-phenoxaphosphine, hydrochloride

Pyrido[1&#39;,2&#39;:4,5][1,4]oxazino[2,3-b]quinoxalines and pyrrolo[1&#39;,2&#39;:4,5][1,4]oxazino[2,3-b]quinoxalines

Substituted 3-benzhydrylthiazolo(3,2-a)pyrimidines

Substituted benz[cd]indol-2-(1H)-ones and use as antihypertensive agents

3-[(α-Substituted-benzyl]-2,3,dihydrothiazolo[3,2-a][1,3]diazacyclan-3-ol derivatives

Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols

N&#39;-(2,6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines

N&#39;-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylformamidines

10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phenyl-10H-phenoxaphosphines

Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation

10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phenyl-10H-phenoxaphosphines compositions containing same and therapeutic methods of use

2-(Substituted amino)benz[cd]indoles

Certain triphenylphosphinimide derivatives

Ester of (triarylphosphoranylidene)carbamic acid having diuretic and ability to lower plasma renin properties

Pyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxalines and pyrrolo[1',2':4,5][1,4]oxazino[2,3-b]quinoxalines

N'-(2,6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines

N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylformamidines