Inventor
COWSERT LEX M
US145 patents
Patents
50 patentsUS7745609B2Jun 29, 2010
Antisense modulation of CD40 expression
ISIS PHARMACEUTICALS INC189 citations99
US6566131B1May 20, 2003
Antisense modulation of Smad6 expression
ISIS PHARMACEUTICALS INC366 citations99
US6426220B1Jul 30, 2002
Antisense modulation of calreticulin expression
ISIS PHARMACEUTICALS INC228 citations99
US6303374B1Oct 16, 2001
Antisense modulation of caspase 3 expression
ISIS PHARMACEUTICALS INC219 citations99
US6107091AAug 22, 2000
Antisense inhibition of G-alpha-16 expression
ISIS PHARMACEUTICALS INC388 citations99
US6100090AAug 8, 2000
Antisense inhibition of PI3K p85 expression
ISIS PHARMACEUTICALS INC137 citations99
US6046321AApr 4, 2000
Antisense modulation of G-alpha-i1 expression
ISIS PHARMACEUTICALS INC372 citations99
US6033910AMar 7, 2000
Antisense inhibition of MAP kinase kinase 6 expression
ISIS PHARMACEUTICALS INC176 citations99
US5998206ADec 7, 1999
Antisense inhibiton of human G-alpha-12 expression
ISIS PHARMACEUTICALS INC203 citations99
US5981732ANov 9, 1999
Antisense modulation of G-alpha-13 expression
ISIS PHARMACEUTICALS INC370 citations99
US5958773ASep 28, 1999
Antisense modulation of AKT-1 expression
ISIS PHARMACEUTICALS INC202 citations99
US5580767ADec 3, 1996
Inhibition of influenza viruses by antisense oligonucleotides
ISIS PHARMACEUTICALS INC158 citations99
US5457189AOct 10, 1995
Antisense oligonucleotide inhibition of papillomavirus
ISIS PHARMACEUTICALS INC224 citations99
US7563884B2Jul 21, 2009
Antisense modulation of PTP1B expression
ISIS PHARMACEUTICALS INC67 citations98
US6524854B1Feb 25, 2003
Antisense inhibition of PKA regulatory subunit RII alpha expression
ISIS PHARMACEUTICALS INC126 citations98
US6261840B1Jul 17, 2001
Antisense modulation of PTP1B expression
ISIS PHARMACEUTICALS INC98 citations98
US6046049AApr 4, 2000
Antisense modulation of PI3 kinase p110 delta expression
ISIS PHARMACEUTICALS INC88 citations98
US6025198AFeb 15, 2000
Antisense modulation of Ship-2 expression
ISIS PHARMACEUTICALS INC107 citations98
US5985663ANov 16, 1999
Antisense inhibition of interleukin-15 expression
ISIS PHARMACEUTICALS INC117 citations98
US5945290AAug 31, 1999
Antisense modulation of RhoA expression
ISIS PHARMACEUTICALS INC91 citations98
US7321828B2Jan 22, 2008
System of components for preparing oligonucleotides
ISIS PHARMACEUTICALS INC216 citations96
US6410323B1Jun 25, 2002
Antisense modulation of human Rho family gene expression
ISIS PHARMACEUTICALS INC384 citations96
US6335194B1Jan 1, 2002
Antisense modulation of survivin expression
ISIS PHARMACEUTICALS INC69 citations96
US6258601B1Jul 10, 2001
Antisense modulation of ubiquitin protein ligase expression
ISIS PHARMACEUTICALS INC75 citations96
US6197584B1Mar 6, 2001
Antisense modulation of CD40 expression
ISIS PHARMACEUTICALS INC59 citations96
US6069008AMay 30, 2000
Antisense modulation of NF-kappa-B p65 subunit expression
ISIS PHARMACEUTICALS INC56 citations96
US6066500AMay 23, 2000
Antisense modulation of Beta catenin expression
ISIS PHARMACEUTICALS INC61 citations96
US6013522AJan 11, 2000
Antisense inhibition of human Smad1 expression
ISIS PHARMACEUTICALS INC86 citations96
US6007995ADec 28, 1999
Antisense inhibition of TNFR1 expression
ISIS PHARMACEUTICALS INC88 citations96
US5951455ASep 14, 1999
Antisense modulation of G-alpha-11 expression
ISIS PHARMACEUTICALS INC65 citations96
US5681944AOct 28, 1997
Antisense oligonucleotides directed to papillomavirus
ISIS PHARMACEUTICALS INC63 citations96
US6184212B1Feb 6, 2001
Antisense modulation of human mdm2 expression
ISIS PHARMACEUTICALS INC78 citations94
US6784290B1Aug 31, 2004
Antisense oligonucleotide inhibition of ras
ISIS PHARMACEUTICALS INC19 citations93
US6613567B1Sep 2, 2003
Antisense inhibition of Her-2 expression
ISIS PHARMACEUTICALS INC22 citations93
US6395545B1May 28, 2002
Antisense modulation of inhibitor-kappa B kinase-alpha expression
ISIS PHARMACEUTICALS INC16 citations93
US6346416B1Feb 12, 2002
Antisense inhibition of HPK/GCK-like kinase expression
ISIS PHARMACEUTICALS INC19 citations93
US6300132B1Oct 9, 2001
Antisense inhibition of telomeric repeat binding factor 2 expression
ISIS PHARMACEUTICALS INC41 citations93
US6284538B1Sep 4, 2001
Antisense inhibition of PTEN expression
ISIS PHARMACEUTICALS INC38 citations93
US6277640B1Aug 21, 2001
Antisense modulation of Her-3 expression
ISIS PHARMACEUTICALS INC32 citations93
US6177273B1Jan 23, 2001
Antisense modulation of integrin-linked kinase expression
ISIS PHARMACEUTICALS INC18 citations93
US6171860B1Jan 9, 2001
Antisense inhibition of rank expression
ISIS PHARMACEUTICALS INC18 citations93
US6165789ADec 26, 2000
Antisense modulation of hnRNP A1 expression
ISIS PHARMACEUTICALS INC28 citations93
US6165786ADec 26, 2000
Antisense modulation of nucleolin expression
ISIS PHARMACEUTICALS INC35 citations93
US6159697ADec 12, 2000
Antisense modulation of Smad7 expression
ISIS PHARMACEUTICALS INC49 citations93
US6140126AOct 31, 2000
Antisense modulation of Y-box binding protein 1 expression
ISIS PHARMACEUTICALS INC35 citations93
US6110664AAug 29, 2000
Antisense inhibition of G-alpha-S1 expression
ISIS PHARMACEUTICALS INC19 citations93
US6043090AMar 28, 2000
Antisense inhibition of human Akt-2 expression
ISIS PHARMACEUTICALS INC20 citations93
US6037176AMar 14, 2000
Antisense inhibition of integrin beta 3 expression
ISIS PHARMACEUTICALS INC37 citations93
US6020199AFeb 1, 2000
Antisense modulation of PTEN expression
ISIS PHARMACEUTICALS INC37 citations93
US6008048ADec 28, 1999
Antisense inhibition of EGR-1 expression
ISIS PHARMACEUTICALS INC47 citations93
Showing the top 50 of 145 patents by PatentIndex Score.