Inventor

SHINKAI ICHIRO

US48 patents

Patents

48 patents

US5391752AFeb 21, 1995

Process for the preparation of antiulcer agents

MERCK & CO INC75 citations93

US5169952ADec 8, 1992

Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

MERCK & CO INC29 citations92

US4292436ASep 29, 1981

Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol

MERCK & CO INC38 citations92

US4140719AFeb 20, 1979

Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline

MERCK & CO INC45 citations92

US4287123ASep 1, 1981

Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

MERCK & CO INC24 citations82

US4282148AAug 4, 1981

Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid

MERCK & CO INC28 citations82

US4940803AJul 10, 1990

Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid

MERCK & CO INC9 citations73

US4467107AAug 21, 1984

1-Hydroxyethyl-2-amino pentanedioic acid derivatives

MERCK & CO INC6 citations73

US4414155ANov 8, 1983

Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid

MERCK & CO INC10 citations73

US4349687ASep 14, 1982

Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid

MERCK & CO INC9 citations73

US4344885AAug 17, 1982

Intermediate for the preparation of thienamycin

MERCK & CO INC9 citations73

US4329481AMay 11, 1982

Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol

MERCK & CO INC14 citations73

US4294988AOct 13, 1981

Method of preparing 2,4-difluoroaniline

MERCK & CO INC10 citations73

US5104984AApr 14, 1992

Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates

MERCK & CO INC8 citations72

US4791207ADec 13, 1988

Enantioselective process for producing 1-betamethylcarbapenem antibiotic intermediates

MERCK & CO INC9 citations72

US5654424AAug 5, 1997

Preparation of beta-methyl carbapenem intermediates

MERCK & CO INC2 citations63

US5087703AFeb 11, 1992

Process for synthesis of FK-506 intermediates

MERCK & CO INC2 citations63

US4980466ADec 25, 1990

Hydroxide mediated FK-506 rearrangement product

MERCK & CO INC2 citations63

US4914220AApr 3, 1990

Process for synthesis of E-2-methyl-α,β-unsaturated aldehydes

MERCK & CO INC6 citations63

US4866186ASep 12, 1989

Process for the formation of 6-desmethyl-6-exo-methylene derivatives of lovastatin and analogs thereof

MERCK & CO INC4 citations63

US4611081ASep 9, 1986

Process for the preparation of HMG-CoA reductase inhibitors intermediates

MERCK & CO INC5 citations63

US4952288AAug 28, 1990

Process for the preparation of 4-acyloxyazetidin-2-one by electrochemical methods

MERCK & CO INC5 citations62

US4942235AJul 17, 1990

Process for certain (2R-trans)hexahydroaroquinolizines

MERCK & CO INC3 citations62

US4940520AJul 10, 1990

Process for the preparation of 4-acyloxyazetidin-2-one by singlet oxygen oxidation

MERCK & CO INC5 citations62

US4923982AMay 8, 1990

Oxidation and reduction method to produce 4-acyloxyazetidin-2-one

MERCK & CO INC3 citations62

US4454332AJun 12, 1984

Hydroxy amino dicarboxylic acids and esters

MERCK & CO INC3 citations62

US4299974ANov 10, 1981

Process for preparing N-protected 2-aminoethanethiol

MERCK & CO INC6 citations62

US4171440AOct 16, 1979

Process for purification of 9-(2,6-dihalobenzyl)adenines

MERCK & CO INC6 citations62

US5235066AAug 10, 1993

FK-506 type macrolide intermediate

MERCK & CO INC3 citations59

US4876364AOct 24, 1989

Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA reductase inhibitors

MERCK & CO INC6 citations57

US4831165AMay 16, 1989

Hydrogenation process for the formation of 3,4-dihydro HMG-CoA reductase inhibitors

MERCK & CO INC4 citations57

US4816577AMar 28, 1989

Process for producing 1-beta-methylcarbapenem antibiotic intermediates

MERCK & CO INC6 citations57

US6242596B1Jun 5, 2001

Preparation of betamethyl carbapenem intermediates

MERCK & CO INC1 citations52

US4871873AOct 3, 1989

Process for synthesis of arylglyoxal arylimines

MERCK & CO INC0 citations52

US4835276AMay 30, 1989

Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1,2,3,4 tetrahydrobenzo [b]furo [2,3-c]pyridine and derivatives

MERCK & CO INC0 citations52

US5177201AJan 5, 1993

Nitrogen deprotected 4-acyloxyazetidin-2-ones

MERCK & CO INC1 citations51

US5064964ANov 12, 1991

Process for certain (2R-trans)hexahydroaroquinolizines

MERCK & CO INC0 citations51

US4864035ASep 5, 1989

Hydrogenation process for the formation of tetrahydro HMG-CoA reductase inhibitors

MERCK & CO INC1 citations51

US4826999AMay 2, 1989

Hydrogenation process for the formation of 3,5-dihydro HMG-CoA reductase inhibitors

MERCK & CO INC1 citations51

US5075436ADec 24, 1991

Chiral 1-β-methyl-carbapenem intermediates

MERCK & CO INC0 citations50

US5164525ANov 17, 1992

Synthetic process for fk-506 type macrolide intermediates

MERCK & CO INC0 citations49

US4814452AMar 21, 1989

Enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one

MERCK & CO INC0 citations46

US5099033AMar 24, 1992

Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as PAF antagonists

MERCK & CO INC0 citations42

US5145957ASep 8, 1992

Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone

MERCK & CO INC0 citations41

SHINKAI ICHIRO

Patents

Process for the preparation of antiulcer agents

Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol

Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline

Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid

Process for synthesis of 1R,2R,5R-2-hydroxy-6-oxo-7-oxabicyclo[3.2.1]-octane

Novel hydroxide mediated FK-506 rearrangement process

Process for synthesis of FK-506 and tricarbonyl intermediates

Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs

Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid

1-Hydroxyethyl-2-amino pentanedioic acid derivatives

Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid

Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid

Intermediate for the preparation of thienamycin

Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol

Method of preparing 2,4-difluoroaniline

Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates

Enantioselective process for producing 1-betamethylcarbapenem antibiotic intermediates

Preparation of beta-methyl carbapenem intermediates

Process for synthesis of FK-506 intermediates

Hydroxide mediated FK-506 rearrangement product

Process for synthesis of E-2-methyl-α,β-unsaturated aldehydes

Process for the formation of 6-desmethyl-6-exo-methylene derivatives of lovastatin and analogs thereof

Process for the preparation of HMG-CoA reductase inhibitors intermediates

Process for the preparation of 4-acyloxyazetidin-2-one by electrochemical methods

Process for certain (2R-trans)hexahydroaroquinolizines

Process for the preparation of 4-acyloxyazetidin-2-one by singlet oxygen oxidation

Oxidation and reduction method to produce 4-acyloxyazetidin-2-one

Hydroxy amino dicarboxylic acids and esters

Process for preparing N-protected 2-aminoethanethiol

Process for purification of 9-(2,6-dihalobenzyl)adenines

FK-506 type macrolide intermediate

Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA reductase inhibitors

Hydrogenation process for the formation of 3,4-dihydro HMG-CoA reductase inhibitors

Process for producing 1-beta-methylcarbapenem antibiotic intermediates

Preparation of betamethyl carbapenem intermediates

Process for synthesis of arylglyoxal arylimines

Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1,2,3,4 tetrahydrobenzo [b]furo [2,3-c]pyridine and derivatives

Nitrogen deprotected 4-acyloxyazetidin-2-ones

Process for certain (2R-trans)hexahydroaroquinolizines

Hydrogenation process for the formation of tetrahydro HMG-CoA reductase inhibitors

Hydrogenation process for the formation of 3,5-dihydro HMG-CoA reductase inhibitors

Chiral 1-β-methyl-carbapenem intermediates

Synthetic process for fk-506 type macrolide intermediates

Enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one

Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as PAF antagonists

Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone