Inventor
GRAHAM MARK J
US66 patents
⚠️ This page may combine multiple inventors who share the name “GRAHAM MARK J”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
ISIS PHARMACEUTICALS INC
26 patentsUS7741305B2Jun 22, 2010
Modulation of apolipoprotein (a) expression
ISIS PHARMACEUTICALS INC135 citations99
US7723508B2May 25, 2010
Modulation of apolipoprotein (A) expression
ISIS PHARMACEUTICALS INC136 citations99
US7425545B2Sep 16, 2008
Modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC158 citations99
US7750141B2Jul 6, 2010
Modulation of apolipoprotein c-III expression
ISIS PHARMACEUTICALS INC64 citations98
US7598227B2Oct 6, 2009
Modulation of apolipoprotein C-III expression
ISIS PHARMACEUTICALS INC292 citations98
US7407943B2Aug 5, 2008
Antisense modulation of apolipoprotein B expression
ISIS PHARMACEUTICALS INC61 citations98
US7335764B2Feb 26, 2008
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
ISIS PHARMACEUTICALS INC119 citations97
US7202357B2Apr 10, 2007
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
ISIS PHARMACEUTICALS INC118 citations97
US9181550B2Nov 10, 2015
Compositions and methods for modulating apolipoprotein (a) expression
ISIS PHARMACEUTICALS INC16 citations96
US9163239B2Oct 20, 2015
Compositions and methods for modulating apolipoprotein C-III expression
ISIS PHARMACEUTICALS INC20 citations96
US7803930B2Sep 28, 2010
Antisense modulation of apolipoprotein B-expression
ISIS PHARMACEUTICALS INC40 citations96
US7259150B2Aug 21, 2007
Modulation of apolipoprotein (a) expression
ISIS PHARMACEUTICALS INC48 citations96
US6184212B1Feb 6, 2001
Antisense modulation of human mdm2 expression
ISIS PHARMACEUTICALS INC78 citations94
US9382540B2Jul 5, 2016
Compositions and methods for modulating angiopoietin-like 3 expression
ISIS PHARMACEUTICALS INC13 citations93
US7863252B2Jan 4, 2011
Modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC22 citations93
US7491815B2Feb 17, 2009
Antisense modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC10 citations93
US7326693B2Feb 5, 2008
Antisense modulation of c-reactive protein expression
ISIS PHARMACEUTICALS INC10 citations93
US7227014B2Jun 5, 2007
Antisense modulation of apolipoprotein (a) expression
ISIS PHARMACEUTICALS INC26 citations93
US6964950B2Nov 15, 2005
Antisense modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC26 citations93
US6767739B2Jul 27, 2004
Antisense modulation of microsomal triglyceride transfer protein expression
ISIS PHARMACEUTICALS INC22 citations93
US6238921B1May 29, 2001
Antisense oligonucleotide modulation of human mdm2 expression
ISIS PHARMACEUTICALS INC23 citations90
US9650636B2May 16, 2017
Methods for treating hypercholesterolemia
ISIS PHARMACEUTICALS INC5 citations84
US8912160B2Dec 16, 2014
Methods for treating hypercholesterolemia
ISIS PHARMACEUTICALS INC4 citations84
US7132529B2Nov 7, 2006
Antisense modulation of stearoyl-CoA desaturase expression
ISIS PHARMACEUTICALS INC12 citations84
US7915231B2Mar 29, 2011
Antisense modulation of C-reactive protein expression
ISIS PHARMACEUTICALS INC3 citations74
US7414033B2Aug 19, 2008
Modulation of diacylglycerol acyltransferase 1 expression
ISIS PHARMACEUTICALS INC8 citations74
IONIS PHARMACEUTICALS INC
14 patentsUS9957504B2May 1, 2018
Compositions and methods for modulating apolipoprotein (a) expression
IONIS PHARMACEUTICALS INC8 citations93
US9932581B2Apr 3, 2018
Compositions and methods for modulating apolipoprotein C-III expression
IONIS PHARMACEUTICALS INC6 citations93
US11851655B2Dec 26, 2023
Compositions and methods for modulating apolipoprotein (a) expression
IONIS PHARMACEUTICALS INC3 citations84
US10927372B2Feb 23, 2021
Compositions and methods for modulating apolipoprotein C-III expression
IONIS PHARMACEUTICALS INC2 citations84
US10883104B2Jan 5, 2021
Compositions and methods for modulating apolipoprotein (a) expression
IONIS PHARMACEUTICALS INC5 citations84
US9957292B2May 1, 2018
Compositions and methods for modulating angiopoietin-like 3 expression
IONIS PHARMACEUTICALS INC11 citations84
US9624496B2Apr 18, 2017
Modulation of apolipoprotein C-III expression
IONIS PHARMACEUTICALS INC3 citations84
US9365848B2Jun 14, 2016
Modulation of apolipoprotein C-III expression
IONIS PHARMACEUTICALS INC4 citations84
US12509684B2Dec 30, 2025
Compositions and methods for modulating apolipoprotein C-III expression
IONIS PHARMACEUTICALS INC0 citations73
US12291709B2May 6, 2025
Compositions and methods for modulating apolipoprotein (a) expression
IONIS PHARMACEUTICALS INC0 citations73
US11530410B2Dec 20, 2022
Methods for treating hypercholesterolemia
IONIS PHARMACEUTICALS INC1 citations73
US10875884B2Dec 29, 2020
Compositions and methods for modulating angiopoietin-like 3 expression
IONIS PHARMACEUTICALS INC4 citations73
US10858657B2Dec 8, 2020
Methods for treating hypercholesterolemia
IONIS PHARMACEUTICALS INC2 citations73
US11634711B2Apr 25, 2023
Methods and compositions for modulating apolipoprotein (a) expression
IONIS PHARMACEUTICALS INC1 citations72
CROOKE ROSANNE M
5 patentsUS8138328B2Mar 20, 2012
Modulation of apolipoprotein (A) expression
CROOKE ROSANNE M30 citations96
US8859514B2Oct 14, 2014
Modulation of C-reactive protein expression
CROOKE ROSANNE M28 citations92
US8673632B2Mar 18, 2014
Modulation of apolipoprotein (a) expression
CROOKE ROSANNE M27 citations92
US8653047B2Feb 18, 2014
Modulation of angiopoietin-like 3 expression
CROOKE ROSANNE M18 citations92
US8530439B2Sep 10, 2013
Modulation of apolipoprotein C-III expression
CROOKE ROSANNE M13 citations92
FREIER SUSAN M
3 patentsGENZYME CORP
1 patentMULLICK ADAM
1 patentShowing the top 50 of 66 patents by PatentIndex Score.