Inventor

WITZEL BRUCE E

50 patents

Patents

50 patents

US4798823AJan 17, 1989

5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors

MERCK & CO INC39 citations92

US4172094AOct 23, 1979

Polyamine compounds

MERCK & CO INC31 citations92

US4720503AJan 19, 1988

N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

MERCK & CO INC27 citations91

US4402959ASep 6, 1983

Antimicrobial compositions

MERCK & CO INC22 citations82

US4311709AJan 19, 1982

Loweralkyl substituted diphenyl polyamine as an antimicrobial agent

MERCK & CO INC20 citations82

US4070400AJan 24, 1978

Diphenyl polyamides having a cyclohexylene moiety

MERCK & CO INC22 citations82

US3956363AMay 11, 1976

Substituted indenyl acetic acids

MERCK & CO INC24 citations82

US4536512AAug 20, 1985

5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents

MERCK & CO INC21 citations81

US5620986AApr 15, 1997

17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders

MERCK & CO INC12 citations74

US4342872AAug 3, 1982

2-(Substitutedpiperidylmethyl) propene and propane nitriles

MERCK & CO INC14 citations74

US4340756AJul 20, 1982

Polyamine compounds as antibacterial agents

MERCK & CO INC11 citations74

US4339453AJul 13, 1982

Antimicrobial aminopyrimidinium salts

MERCK & CO INC13 citations74

US4335141AJun 15, 1982

2-Substituted-aminopropene-and propanenitrile antimicrobial and anti-inflammatory agents

MERCK & CO INC17 citations74

US4244963AJan 13, 1981

1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines useful as antimicrobial and antiinflammatory agents

MERCK & CO INC13 citations74

US4145426AMar 20, 1979

Anti-microbial piperidino butan-2-ones

MERCK & CO INC14 citations74

US4125719ANov 14, 1978

1,3,5-S-Hexahydrotrisubstituted triazines

MERCK & CO INC6 citations74

US4119779AOct 10, 1978

1,3,5-S-Hexahydrotrisubstituted triazines

MERCK & CO INC13 citations74

US4061775ADec 6, 1977

Polyamine compounds as antibacterial agents

MERCK & CO INC10 citations74

US5639741AJun 17, 1997

17-amino substituted 4-azasteroid 5α-reductase inhibitors

MERCK & CO INC16 citations73

US4663344AMay 5, 1987

Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor

MERCK & CO INC15 citations73

US4533671AAug 6, 1985

5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents

MERCK & CO INC14 citations73

US4440779AApr 3, 1984

Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents

MERCK & CO INC10 citations73

US4131677ADec 26, 1978

Anti-inflammatory oxazolo [5,4-b]pyridines

MERCK & CO INC17 citations73

US4049417ASep 20, 1977

Alicyclic alkylene polyamine microorganism and algae growth inhibitors

MERCK & CO INC7 citations73

US4782080ANov 1, 1988

N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

MERCK & CO INC5 citations63

US4316903AFeb 23, 1982

Anti-microbial piperidino buten-2-ones

MERCK & CO INC3 citations63

US4260760AApr 7, 1981

Diaryl-aliphatic-amino-aliphatic-piperazines

MERCK & CO INC2 citations63

US4250184AFeb 10, 1981

Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones

MERCK & CO INC3 citations63

US4247700AJan 27, 1981

2-(Substitutedpiperidylmethyl)propene and propane nitriles

MERCK & CO INC2 citations63

US4159254AJun 26, 1979

1,3,5-S-Hexahydrotrisubstituted triazines and hydrocarbon metal working fluids containing same

MERCK & CO INC4 citations63

US4079059AMar 14, 1978

Diphenyl derivatives of polyamine compounds having a piperidine moiety

MERCK & CO INC4 citations63

US5068248ANov 26, 1991

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

MERCK & CO INC3 citations62

US4760086AJul 26, 1988

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

MERCK & CO INC4 citations62

US4999436AMar 12, 1991

Aryl-substituted thiophene 3-ols, derivatives and analogs useful as lipoxgenase inhibitors

MERCK & CO INC6 citations61

US4431655AFeb 14, 1984

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials

MERCK & CO INC0 citations52

US4391812AJul 5, 1983

2-(Substitutedpiperidylmethyl) propane nitriles and compositions thereof

MERCK & CO INC0 citations52

US4362877ADec 7, 1982

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials

MERCK & CO INC0 citations52

US4342873AAug 3, 1982

2-(Substituted piperidylmethyl) propene and propane nitriles

MERCK & CO INC1 citations52

US4273781AJun 16, 1981

Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones

MERCK & CO INC0 citations52

US4380645AApr 19, 1983

Process for preparing Benzoxepino- or Benzthiapino[4,3-b]pyrrole-2-acetic acids

MERCK & CO INC1 citations51

US4814501AMar 21, 1989

Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs

MERCK & CO INC0 citations50

US4254131AMar 3, 1981

Treatment of pain, fever, and inflammation with compositions containing 2-(substitutedpiperidinomethyl)propane and propene nitriles

MERCK & CO INC0 citations42

WITZEL BRUCE E

Patents

New cyclosporin analogs with modified &#34;C-9 amino acids&#34;

Cyclosporin analogs with modified &#34;C-9 amino acids&#34;

Ester derivatives of 4-aza-steroids

17-Ethers and thioethers of 4-aza-steroids

Anti-inflammatory oxazole[4,5-b]pyridines

Antimicrobial additive for metal working fluids

7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors

Substituted 4-aza-5α-androstan-ones as 5α-reductase inhibitors

5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors

Polyamine compounds

N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

Antimicrobial compositions

Loweralkyl substituted diphenyl polyamine as an antimicrobial agent

Diphenyl polyamides having a cyclohexylene moiety

Substituted indenyl acetic acids

5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents

17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders

2-(Substitutedpiperidylmethyl) propene and propane nitriles

Polyamine compounds as antibacterial agents

Antimicrobial aminopyrimidinium salts

2-Substituted-aminopropene-and propanenitrile antimicrobial and anti-inflammatory agents

1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines useful as antimicrobial and antiinflammatory agents

Anti-microbial piperidino butan-2-ones

1,3,5-S-Hexahydrotrisubstituted triazines

1,3,5-S-Hexahydrotrisubstituted triazines

Polyamine compounds as antibacterial agents

17-amino substituted 4-azasteroid 5α-reductase inhibitors

Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor

5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents

Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents

Anti-inflammatory oxazolo [5,4-b]pyridines

Alicyclic alkylene polyamine microorganism and algae growth inhibitors

N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

Anti-microbial piperidino buten-2-ones

Diaryl-aliphatic-amino-aliphatic-piperazines

Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones

2-(Substitutedpiperidylmethyl)propene and propane nitriles

1,3,5-S-Hexahydrotrisubstituted triazines and hydrocarbon metal working fluids containing same

Diphenyl derivatives of polyamine compounds having a piperidine moiety

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

Aryl-substituted thiophene 3-ols, derivatives and analogs useful as lipoxgenase inhibitors

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials

2-(Substitutedpiperidylmethyl) propane nitriles and compositions thereof

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials

2-(Substituted piperidylmethyl) propene and propane nitriles

Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones

Process for preparing Benzoxepino- or Benzthiapino[4,3-b]pyrrole-2-acetic acids

Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs

Treatment of pain, fever, and inflammation with compositions containing 2-(substitutedpiperidinomethyl)propane and propene nitriles

New cyclosporin analogs with modified "C-9 amino acids"

Cyclosporin analogs with modified "C-9 amino acids"