Inventor

HOLMES MICHAEL C

US64 patents

⚠️ This page may combine multiple inventors who share the name “HOLMES MICHAEL C”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.

HOLMES MICHAEL C

SANGAMO BIOSCIENCES INC

Engineered cleavage half-domains

Methods and compositions for targeted cleavage and recombination

Gene correction of SCID-related genes in hematopoietic stem and progenitor cells

T cell modifying compounds and uses thereof

Methods and compositions for gene inactivation

Methods and compositions for targeted cleavage and recombination

Methods and compositions for gene inactivation

Targeted disruption of T cell receptor genes using talens

Methods and compositions for modification of the HPRT locus

Methods and compositions for modification of a HLA locus

Delivery methods and compositions for nuclease-mediated genome engineering

Targeted integration and expression on exogenous nucleic acid sequences

Methods and compositions for modification of the HPRT locus

Methods and compositions for modulating PD1

Methods and compositions for treating hemophilia B

Delivery methods and compositions for nuclease-mediated genome engineering

Isolated human cell with an inactivated glucocorticoid receptor gene

Methods and compositions for treatment of a genetic condition

Linear donor constructs for targeted integration

Methods and compostions for targeted genomic deletion

Modification of CXCR4 using engineered zinc finger proteins

Methods and compositions for treatment of a genetic condition

Methods and compositions for prevention or treatment of a disease

Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases

Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells

Rapid screening of biologically active nucleases and isolation of nuclease-modified cells

Linear donor constructs for targeted integration

SANGAMO THERAPEUTICS INC

Gene correction of SCID-related genes in hematopoietic stem and progenitor cells

Methods and compositions for targeted cleavage and recombination

T cell modifying compounds and uses thereof

Method of inactivating a glucocorticoid receptor gene in an isolated cell

Method of making and using mammalian liver cells for treating hemophilia or lysosomal storage disorder

Methods and compositions for treatment of a genetic condition

GREGORY PHILIP D

Methods and compositions for modulating PD1

Genome editing of a Rosa locus using nucleases

Methods and compositions for treating hemophilia B

Targeted integration into stem cells

HOLMES MICHAEL C

Methods and compositions for inhibiting viral entry into cells

Modification of CXCR4 using engineered zinc finger proteins

Rapid screening of biologically active nucleases and isolation of nuclease-modified cells

Methods and compositions for targeted integration

ANDO DALE

Methods and compositions for gene inactivation

Methods and compositions for gene inactivation

COLLINGWOOD TREVOR

Methods and compositions for modification of a HLA locus

DEKELVER RUSSELL

Linear donor constructs for targeted integration

BONINI MARIA CHIARA

Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases

GUSCHIN DMITRY

Targeted deletion of cellular DNA sequences

CUI XIAOXIA

Genome editing of a Rosa locus using zinc-finger nucleases

URNOV FYODOR

Methods and compositions for targeted cleavage and recombination

GUSCHIN DMITRY M

Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene