Inventor
IRVINE DARRELL J
US56 patents
⚠️ This page may combine multiple inventors who share the name “IRVINE DARRELL J”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
MASSACHUSETTS INST TECHNOLOGY
40 patentsUS6150459ANov 21, 2000
Comb polymers for regulating cell surface interactions
MASSACHUSETTS INST TECHNOLOGY108 citations98
US6207749B1Mar 27, 2001
Comb copolymers for regulating cell-surface interactions
MASSACHUSETTS INST TECHNOLOGY101 citations97
US9445994B2Sep 20, 2016
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY24 citations94
US9603944B2Mar 28, 2017
Carrier-free biologically-active protein nanostructures
MASSACHUSETTS INST TECHNOLOGY13 citations93
US9750803B2Sep 5, 2017
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY14 citations92
US9339462B2May 17, 2016
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY12 citations92
US8951542B2Feb 10, 2015
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY15 citations92
US6399700B2Jun 4, 2002
Comb copolymers for regulating cell-surface interactions
MASSACHUSETTS INST TECHNOLOGY27 citations92
US9393199B2Jul 19, 2016
Methods and compositions for localized agent delivery
MASSACHUSETTS INST TECHNOLOGY15 citations91
US10588942B2Mar 17, 2020
Carrier-free biologically-active protein nanostructures
MASSACHUSETTS INST TECHNOLOGY5 citations84
US10357544B2Jul 23, 2019
Carrier-free biologically-active protein nanostructures
MASSACHUSETTS INST TECHNOLOGY6 citations84
US10226510B2Mar 12, 2019
Carrier-free biologically-active protein nanostructures
MASSACHUSETTS INST TECHNOLOGY8 citations84
US9907753B2Mar 6, 2018
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY8 citations84
US9616020B2Apr 11, 2017
Lipid vesicle compositions and methods of use
MASSACHUSETTS INST TECHNOLOGY9 citations84
US11034752B2Jun 15, 2021
Cell surface coupling of nanoparticles
MASSACHUSETTS INST TECHNOLOGY5 citations81
US11261226B2Mar 1, 2022
Cell surface coupling of nanoparticles
MASSACHUSETTS INST TECHNOLOGY2 citations70
US11448643B2Sep 20, 2022
Methods to specifically profile protease activity at lymph nodes
MASSACHUSETTS INST TECHNOLOGY5 citations68
US10888603B2Jan 12, 2021
Methods of treating cancer cells expressing tumor-associated integrins
MASSACHUSETTS INST TECHNOLOGY4 citations68
US11419947B2Aug 23, 2022
Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
MASSACHUSETTS INST TECHNOLOGY2 citations64
US11351271B2Jun 7, 2022
RNA-based logic circuits with RNA binding proteins, aptamers and small molecules
MASSACHUSETTS INST TECHNOLOGY2 citations64
US11529392B2Dec 20, 2022
Carrier-free biologically-active protein nanostructures
MASSACHUSETTS INST TECHNOLOGY0 citations63
US12286646B2Apr 29, 2025
Methods for in vitro evolution of constructs derived from viruses
MASSACHUSETTS INST TECHNOLOGY0 citations62
US12433946B2Oct 7, 2025
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
MASSACHUSETTS INST TECHNOLOGY0 citations60
US12383589B2Aug 12, 2025
Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy
MASSACHUSETTS INST TECHNOLOGY0 citations60
US12246097B2Mar 11, 2025
Nanoparticle vaccine adjuvant and methods of use thereof
MASSACHUSETTS INST TECHNOLOGY1 citations60
US11717548B2Aug 8, 2023
Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy
MASSACHUSETTS INST TECHNOLOGY1 citations60
US11642409B2May 9, 2023
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
MASSACHUSETTS INST TECHNOLOGY0 citations60
US9415070B2Aug 16, 2016
Methods and compositions for localized delivery of agents to virally infected cells and tissues
MASSACHUSETTS INST TECHNOLOGY2 citations60
US12410392B2Sep 9, 2025
Delivery of biomolecules to immune cells
MASSACHUSETTS INST TECHNOLOGY0 citations59
US11224648B2Jan 18, 2022
Antigen-adjuvant coupling reagents and methods of use
MASSACHUSETTS INST TECHNOLOGY0 citations59
US11547672B2Jan 10, 2023
Nanoparticle vaccine adjuvant and methods of use thereof
MASSACHUSETTS INST TECHNOLOGY1 citations58
US11207418B2Dec 28, 2021
Synthetic nanoparticles for delivery of immunomodulatory compounds
MASSACHUSETTS INST TECHNOLOGY0 citations58
US11026894B2Jun 8, 2021
Lipid nanoparticles and use thereof to deliver RNA polynucleotides
MASSACHUSETTS INST TECHNOLOGY1 citations58
US10300145B2May 28, 2019
Synthetic nanoparticles for delivery of immunomodulatory compounds
MASSACHUSETTS INST TECHNOLOGY1 citations58
US12295986B2May 13, 2025
Combination immunotherapy for treatment of melanoma, colon or non-small cell lung cancers
MASSACHUSETTS INST TECHNOLOGY0 citations57
US11235032B2Feb 1, 2022
Combination immunotherapy dosing regimen for immune checkpoint blockade
MASSACHUSETTS INST TECHNOLOGY0 citations57
US12139721B2Nov 12, 2024
Control of replication and transcription of self-replicating RNA in response to small molecules
MASSACHUSETTS INST TECHNOLOGY0 citations56
US11964026B2Apr 23, 2024
Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
MASSACHUSETTS INST TECHNOLOGY0 citations54
US11642416B2May 9, 2023
Albumin binding peptide conjugates and methods thereof
MASSACHUSETTS INST TECHNOLOGY0 citations54
US11077199B2Aug 3, 2021
Albumin binding peptide conjugates and methods thereof
MASSACHUSETTS INST TECHNOLOGY1 citations54
IRVINE DARRELL J
3 patentsUS8747869B2Jun 10, 2014
Lipid vesicle compositions and methods of use
IRVINE DARRELL J51 citations97
US9149432B2Oct 6, 2015
Lipid vesicle compositions and methods of use
IRVINE DARRELL J14 citations92
US9283184B2Mar 15, 2016
Methods and compositions for localized agent delivery
IRVINE DARRELL J14 citations82
WARREN WILLIAM L
2 patentsSANOFI PASTEUR VAXDESIGN CORP
2 patentsJANSSEN VACCINES & PREVENTION BV
2 patentsVAXDESIGN CORP
1 patentShowing the top 50 of 56 patents by PatentIndex Score.