P

Inventor

IRVINE DARRELL J

US56 patents
⚠️ This page may combine multiple inventors who share the name “IRVINE DARRELL J”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.

MASSACHUSETTS INST TECHNOLOGY

40 patents
US6150459ANov 21, 2000

Comb polymers for regulating cell surface interactions

MASSACHUSETTS INST TECHNOLOGY108 citations98
US6207749B1Mar 27, 2001

Comb copolymers for regulating cell-surface interactions

MASSACHUSETTS INST TECHNOLOGY101 citations97
US9445994B2Sep 20, 2016

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY24 citations94
US9603944B2Mar 28, 2017

Carrier-free biologically-active protein nanostructures

MASSACHUSETTS INST TECHNOLOGY13 citations93
US9750803B2Sep 5, 2017

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY14 citations92
US9339462B2May 17, 2016

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY12 citations92
US8951542B2Feb 10, 2015

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY15 citations92
US6399700B2Jun 4, 2002

Comb copolymers for regulating cell-surface interactions

MASSACHUSETTS INST TECHNOLOGY27 citations92
US9393199B2Jul 19, 2016

Methods and compositions for localized agent delivery

MASSACHUSETTS INST TECHNOLOGY15 citations91
US10588942B2Mar 17, 2020

Carrier-free biologically-active protein nanostructures

MASSACHUSETTS INST TECHNOLOGY5 citations84
US10357544B2Jul 23, 2019

Carrier-free biologically-active protein nanostructures

MASSACHUSETTS INST TECHNOLOGY6 citations84
US10226510B2Mar 12, 2019

Carrier-free biologically-active protein nanostructures

MASSACHUSETTS INST TECHNOLOGY8 citations84
US9907753B2Mar 6, 2018

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY8 citations84
US9616020B2Apr 11, 2017

Lipid vesicle compositions and methods of use

MASSACHUSETTS INST TECHNOLOGY9 citations84
US11034752B2Jun 15, 2021

Cell surface coupling of nanoparticles

MASSACHUSETTS INST TECHNOLOGY5 citations81
US11261226B2Mar 1, 2022

Cell surface coupling of nanoparticles

MASSACHUSETTS INST TECHNOLOGY2 citations70
US11448643B2Sep 20, 2022

Methods to specifically profile protease activity at lymph nodes

MASSACHUSETTS INST TECHNOLOGY5 citations68
US10888603B2Jan 12, 2021

Methods of treating cancer cells expressing tumor-associated integrins

MASSACHUSETTS INST TECHNOLOGY4 citations68
US11419947B2Aug 23, 2022

Layer-by-layer nanoparticles for cytokine therapy in cancer treatment

MASSACHUSETTS INST TECHNOLOGY2 citations64
US11351271B2Jun 7, 2022

RNA-based logic circuits with RNA binding proteins, aptamers and small molecules

MASSACHUSETTS INST TECHNOLOGY2 citations64
US11529392B2Dec 20, 2022

Carrier-free biologically-active protein nanostructures

MASSACHUSETTS INST TECHNOLOGY0 citations63
US12286646B2Apr 29, 2025

Methods for in vitro evolution of constructs derived from viruses

MASSACHUSETTS INST TECHNOLOGY0 citations62
US12433946B2Oct 7, 2025

Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof

MASSACHUSETTS INST TECHNOLOGY0 citations60
US12383589B2Aug 12, 2025

Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy

MASSACHUSETTS INST TECHNOLOGY0 citations60
US12246097B2Mar 11, 2025

Nanoparticle vaccine adjuvant and methods of use thereof

MASSACHUSETTS INST TECHNOLOGY1 citations60
US11717548B2Aug 8, 2023

Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy

MASSACHUSETTS INST TECHNOLOGY1 citations60
US11642409B2May 9, 2023

Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof

MASSACHUSETTS INST TECHNOLOGY0 citations60
US9415070B2Aug 16, 2016

Methods and compositions for localized delivery of agents to virally infected cells and tissues

MASSACHUSETTS INST TECHNOLOGY2 citations60
US12410392B2Sep 9, 2025

Delivery of biomolecules to immune cells

MASSACHUSETTS INST TECHNOLOGY0 citations59
US11224648B2Jan 18, 2022

Antigen-adjuvant coupling reagents and methods of use

MASSACHUSETTS INST TECHNOLOGY0 citations59
US11547672B2Jan 10, 2023

Nanoparticle vaccine adjuvant and methods of use thereof

MASSACHUSETTS INST TECHNOLOGY1 citations58
US11207418B2Dec 28, 2021

Synthetic nanoparticles for delivery of immunomodulatory compounds

MASSACHUSETTS INST TECHNOLOGY0 citations58
US11026894B2Jun 8, 2021

Lipid nanoparticles and use thereof to deliver RNA polynucleotides

MASSACHUSETTS INST TECHNOLOGY1 citations58
US10300145B2May 28, 2019

Synthetic nanoparticles for delivery of immunomodulatory compounds

MASSACHUSETTS INST TECHNOLOGY1 citations58
US12295986B2May 13, 2025

Combination immunotherapy for treatment of melanoma, colon or non-small cell lung cancers

MASSACHUSETTS INST TECHNOLOGY0 citations57
US11235032B2Feb 1, 2022

Combination immunotherapy dosing regimen for immune checkpoint blockade

MASSACHUSETTS INST TECHNOLOGY0 citations57
US12139721B2Nov 12, 2024

Control of replication and transcription of self-replicating RNA in response to small molecules

MASSACHUSETTS INST TECHNOLOGY0 citations56
US11964026B2Apr 23, 2024

Layer-by-layer nanoparticles for cytokine therapy in cancer treatment

MASSACHUSETTS INST TECHNOLOGY0 citations54
US11642416B2May 9, 2023

Albumin binding peptide conjugates and methods thereof

MASSACHUSETTS INST TECHNOLOGY0 citations54
US11077199B2Aug 3, 2021

Albumin binding peptide conjugates and methods thereof

MASSACHUSETTS INST TECHNOLOGY1 citations54

IRVINE DARRELL J

3 patents

WARREN WILLIAM L

2 patents

SANOFI PASTEUR VAXDESIGN CORP

2 patents

JANSSEN VACCINES & PREVENTION BV

2 patents

VAXDESIGN CORP

1 patent

Showing the top 50 of 56 patents by PatentIndex Score.