Inventor
CHARTRAIN MICHEL M
US12 patents
Patents
12 patentsUS5491077AFeb 13, 1996
Microbial method
MERCK & CO INC92 citations95
US5474919ADec 12, 1995
Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae
MERCK & CO INC21 citations88
US5792871AAug 11, 1998
Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide
MERCK & CO INC17 citations82
US5523233AJun 4, 1996
Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
MERCK & CO INC7 citations72
US6228622B1May 8, 2001
11-hydroxysordarin and a process for producing it using actinomyces SSP
MERCK & CO INC6 citations70
US5858737AJan 12, 1999
Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
MERCK & CO INC6 citations67
US5849568ADec 15, 1998
Resolution of racemic indene oxide to yield (1S,2R)-indene oxide using Diplodia gossipina
MERCK & CO INC4 citations61
US5846791ADec 8, 1998
N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide
MERCK & CO INC5 citations61
US5605819AFeb 25, 1997
Quantitative conversion of indene to (1S,2R) indene oxide and (1S,2R)-indandiol by combination of haloperoxidase bioconversion and chemical steps
MERCK & CO INC4 citations59
US5900368AMay 4, 1999
Process for bioreduction of bisaryl ketone to bisaryl alcohol
MERCK & CO INC1 citations48
US6121026ASep 19, 2000
Enantioselective bioreduction using yeast
MERCK & CO INC0 citations47
US5464762ANov 7, 1995
Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2 tetraol by trichosporon capitatum
MERCK & CO INC0 citations45