Inventor
LIU DAVID R
US154 patents
⚠️ This page may combine multiple inventors who share the name “LIU DAVID R”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
HARVARD COLLEGE
37 patentsUS10077453B2Sep 18, 2018
CAS9 proteins including ligand-dependent inteins
HARVARD COLLEGE134 citations99
US9163284B2Oct 20, 2015
Methods for identifying a target site of a Cas9 nuclease
HARVARD COLLEGE119 citations99
US11053481B2Jul 6, 2021
Fusions of Cas9 domains and nucleic acid-editing domains
HARVARD COLLEGE79 citations98
US10954548B2Mar 23, 2021
Nuclease profiling system
HARVARD COLLEGE59 citations98
US10704062B2Jul 7, 2020
CAS9 proteins including ligand-dependent inteins
HARVARD COLLEGE63 citations98
US10682410B2Jun 16, 2020
Delivery system for functional nucleases
HARVARD COLLEGE83 citations98
US10597679B2Mar 24, 2020
Switchable Cas9 nucleases and uses thereof
HARVARD COLLEGE80 citations98
US10508298B2Dec 17, 2019
Methods for identifying a target site of a CAS9 nuclease
HARVARD COLLEGE65 citations98
US10167457B2Jan 1, 2019
Nucleobase editors and uses thereof
HARVARD COLLEGE214 citations98
US10113163B2Oct 30, 2018
Adenosine nucleobase editors and uses thereof
HARVARD COLLEGE249 citations98
US9840699B2Dec 12, 2017
Methods for nucleic acid editing
HARVARD COLLEGE193 citations98
US9737604B2Aug 22, 2017
Use of cationic lipids to deliver CAS9
HARVARD COLLEGE140 citations98
US9526784B2Dec 27, 2016
Delivery system for functional nucleases
HARVARD COLLEGE123 citations98
US9388430B2Jul 12, 2016
Cas9-recombinase fusion proteins and uses thereof
HARVARD COLLEGE126 citations98
US9340799B2May 17, 2016
MRNA-sensing switchable gRNAs
HARVARD COLLEGE121 citations98
US9340800B2May 17, 2016
Extended DNA-sensing GRNAS
HARVARD COLLEGE95 citations98
US9322037B2Apr 26, 2016
Cas9-FokI fusion proteins and uses thereof
HARVARD COLLEGE187 citations98
US9228207B2Jan 5, 2016
Switchable gRNAs comprising aptamers
HARVARD COLLEGE106 citations98
US9068179B1Jun 30, 2015
Methods for correcting presenilin point mutations
HARVARD COLLEGE135 citations98
US7223545B2May 29, 2007
Evolving new molecular function
HARVARD COLLEGE93 citations98
US11299755B2Apr 12, 2022
Switchable CAS9 nucleases and uses thereof
HARVARD COLLEGE35 citations97
US11214780B2Jan 4, 2022
Nucleobase editors and uses thereof
HARVARD COLLEGE35 citations97
US11124782B2Sep 21, 2021
Cas variants for gene editing
HARVARD COLLEGE70 citations97
US11046948B2Jun 29, 2021
Engineered transcription activator-like effector (TALE) domains and uses thereof
HARVARD COLLEGE64 citations97
US10947530B2Mar 16, 2021
Adenosine nucleobase editors and uses thereof
HARVARD COLLEGE71 citations97
US10912833B2Feb 9, 2021
Delivery of negatively charged proteins using cationic lipids
HARVARD COLLEGE66 citations97
US10858639B2Dec 8, 2020
CAS9 variants and uses thereof
HARVARD COLLEGE65 citations97
US10745677B2Aug 18, 2020
Editing of CCR5 receptor gene to protect against HIV infection
HARVARD COLLEGE68 citations97
US10465176B2Nov 5, 2019
Cas variants for gene editing
HARVARD COLLEGE76 citations97
US10392674B2Aug 27, 2019
Evolution of site-specific recombinases
HARVARD COLLEGE62 citations97
US10336997B2Jul 2, 2019
Continuous directed evolution
HARVARD COLLEGE69 citations97
US10227581B2Mar 12, 2019
Engineered transcription activator-like effector (TALE) domains and uses thereof
HARVARD COLLEGE86 citations97
US10179911B2Jan 15, 2019
Negative selection and stringency modulation in continuous evolution systems
HARVARD COLLEGE78 citations97
US9999671B2Jun 19, 2018
Delivery of negatively charged proteins using cationic lipids
HARVARD COLLEGE76 citations97
US9771574B2Sep 26, 2017
Apparatus for continuous directed evolution of proteins and nucleic acids
HARVARD COLLEGE81 citations97
US9359599B2Jun 7, 2016
Engineered transcription activator-like effector (TALE) domains and uses thereof
HARVARD COLLEGE95 citations97
US9322006B2Apr 26, 2016
Evaluation and improvement of nuclease cleavage specificity
HARVARD COLLEGE93 citations97
SCRIPPS RESEARCH INST
6 patentsUS8030074B2Oct 4, 2011
In vivo incorporation of unnatural amino acids
SCRIPPS RESEARCH INST53 citations98
US8012739B2Sep 6, 2011
Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs
SCRIPPS RESEARCH INST43 citations98
US7713721B2May 11, 2010
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
SCRIPPS RESEARCH INST49 citations98
US7638300B2Dec 29, 2009
In vivo incorporation of unnatural amino acids
SCRIPPS RESEARCH INST63 citations98
US7368275B2May 6, 2008
In vivo incorporation of unnatural amino acids
SCRIPPS RESEARCH INST76 citations98
US7354761B2Apr 8, 2008
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
SCRIPPS RESEARCH INST77 citations98
LIU DAVID R
3 patentsUNIV CALIFORNIA
2 patentsHELICOS BIOSCIENCES CORP
1 patentSCHULTZ PETER G
1 patentShowing the top 50 of 154 patents by PatentIndex Score.