Inventor
DEAN NICHOLAS M
US50 patents
⚠️ This page may combine multiple inventors who share the name “DEAN NICHOLAS M”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
ISIS PHARMACEUTICALS INC
38 patentsUS6001992ADec 14, 1999
Antisense modulation of novel anti-apoptotic bcl-2-related proteins
ISIS PHARMACEUTICALS INC230 citations99
US5877309AMar 2, 1999
Antisense oligonucleotides against JNK
ISIS PHARMACEUTICALS INC189 citations99
US6172216B1Jan 9, 2001
Antisense modulation of BCL-X expression
ISIS PHARMACEUTICALS INC399 citations98
US6214986B1Apr 10, 2001
Antisense modulation of bcl-x expression
ISIS PHARMACEUTICALS INC86 citations97
US5801154ASep 1, 1998
Antisense oligonucleotide modulation of multidrug resistance-associated protein
ISIS PHARMACEUTICALS INC1,636 citations97
US7148204B2Dec 12, 2006
Antisense modulation of bcl-x expression
ISIS PHARMACEUTICALS INC145 citations96
US6136603AOct 24, 2000
Antisense modulation of interleukin-5 signal transduction
ISIS PHARMACEUTICALS INC72 citations96
US5985558ANov 16, 1999
Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
ISIS PHARMACEUTICALS INC101 citations96
US7879992B2Feb 1, 2011
Modification of MyD88 splicing using modified oligonucleotides
ISIS PHARMACEUTICALS INC42 citations95
US6312900B1Nov 6, 2001
Antisense oligonucleotide compositions and methods for the modulation of activating protein 1
ISIS PHARMACEUTICALS INC59 citations94
US6346416B1Feb 12, 2002
Antisense inhibition of HPK/GCK-like kinase expression
ISIS PHARMACEUTICALS INC19 citations93
US6087489AJul 11, 2000
Antisense oligonucleotide modulation of human thymidylate synthase expression
ISIS PHARMACEUTICALS INC18 citations93
US6001991ADec 14, 1999
Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
ISIS PHARMACEUTICALS INC35 citations93
US6809193B2Oct 26, 2004
Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
ISIS PHARMACEUTICALS INC33 citations92
US6339066B1Jan 15, 2002
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
ISIS PHARMACEUTICALS INC29 citations92
US6204055B1Mar 20, 2001
Antisense inhibition of Fas mediated signaling
ISIS PHARMACEUTICALS INC31 citations92
US5959096ASep 28, 1999
Antisense oligonucleotides against human protein kinase C
ISIS PHARMACEUTICALS INC20 citations92
US5916807AJun 29, 1999
Antisense oligonucleotides against human protein kinase C
ISIS PHARMACEUTICALS INC25 citations92
US5885970AMar 23, 1999
Antisense oligonucleotides against human protein kinase C
ISIS PHARMACEUTICALS INC48 citations92
US5703054ADec 30, 1997
Oligonucleotide modulation of protein kinase C
ISIS PHARMACEUTICALS INC41 citations92
US7759318B1Jul 20, 2010
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
ISIS PHARMACEUTICALS INC23 citations91
US6436909B1Aug 20, 2002
Antisense inhibition of transforming growth factor-β expression
ISIS PHARMACEUTICALS INC21 citations91
US5681747AOct 28, 1997
Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
ISIS PHARMACEUTICALS INC37 citations91
US9157081B2Oct 13, 2015
Chimeric oligomeric compounds for modulation of splicing
ISIS PHARMACEUTICALS INC29 citations90
US6537973B1Mar 25, 2003
Oligonucleotide inhibition of protein kinase C
ISIS PHARMACEUTICALS INC24 citations86
US6180353B1Jan 30, 2001
Antisense modulation of daxx expression
ISIS PHARMACEUTICALS INC16 citations84
US6235723B1May 22, 2001
Antisense oligonucleotide modulation of human protein kinase C-δ expression
ISIS PHARMACEUTICALS INC9 citations74
US5948898ASep 7, 1999
Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
ISIS PHARMACEUTICALS INC9 citations74
US6117847ASep 12, 2000
Oligonucleotides for enhanced modulation of protein kinase C expression
ISIS PHARMACEUTICALS INC9 citations73
US5922686AJul 13, 1999
Oligonucleotide modulation of protein kinase C
ISIS PHARMACEUTICALS INC8 citations73
US5882927AMar 16, 1999
Oligonucleotide inhibition of protein kinase C
ISIS PHARMACEUTICALS INC15 citations73
US6015892AJan 18, 2000
Oligonucleotide modulation of protein kinase C
ISIS PHARMACEUTICALS INC6 citations72
US6653133B1Nov 25, 2003
Antisense modulation of Fas mediated signaling
ISIS PHARMACEUTICALS INC2 citations63
US6300320B1Oct 9, 2001
Modulation of c-jun using inhibitors of protein kinase C
ISIS PHARMACEUTICALS INC3 citations63
US6153599ANov 28, 2000
Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
ISIS PHARMACEUTICALS INC4 citations63
US7563885B1Jul 21, 2009
Modulation of Tudor-SN expression
ISIS PHARMACEUTICALS INC2 citations60
US7375212B2May 20, 2008
Modulation of Aurora B expression
ISIS PHARMACEUTICALS INC1 citations52
US6599742B2Jul 29, 2003
Antisense oligonucleotide inhibition of human serine/threonine protein phosphatase gene expression
ISIS PHARMACEUTICALS INC0 citations50
DEAN NICHOLAS M
4 patentsUS8252762B2Aug 28, 2012
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
DEAN NICHOLAS M5 citations70
US9096851B2Aug 4, 2015
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
DEAN NICHOLAS M2 citations59
US8772260B2Jul 8, 2014
Methods for inhibiting expression of connective tissue growth factor
DEAN NICHOLAS M0 citations49
US9173894B2Nov 3, 2015
Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
DEAN NICHOLAS M1 citations44