P

Inventor

KEEFER LARRY K

US53 patents
⚠️ This page may combine multiple inventors who share the name “KEEFER LARRY K”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.

US HEALTH

44 patents
US6232336B1May 15, 2001

Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH115 citations99
US5814666ASep 29, 1998

Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents

US HEALTH320 citations99
US5691423ANov 25, 1997

Polysaccharide-bound nitric oxide-nucleophile adducts

US HEALTH160 citations99
US5676963AOct 14, 1997

Implants, prostheses, and stents comprising polymer-bound nitric oxide/nucleophile adducts capable of releasing nitric oxide

US HEALTH144 citations99
US5525357AJun 11, 1996

Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US HEALTH258 citations99
US5405919AApr 11, 1995

Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders

US HEALTH334 citations99
US5155137AOct 13, 1992

Complexes of nitric oxide with polyamines

US HEALTH176 citations99
US4954526ASep 4, 1990

Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents

US HEALTH196 citations99
US7928079B2Apr 19, 2011

Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates

US HEALTH56 citations98
US6673338B1Jan 6, 2004

Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same

US HEALTH100 citations98
US6511991B2Jan 28, 2003

Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH97 citations98
US6110453AAug 29, 2000

Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US HEALTH87 citations98
US5910316AJun 8, 1999

Use of nitric oxide-releasing agents to treat impotency

US HEALTH170 citations98
US5683668ANov 4, 1997

Method of generating nitric oxide gas using nitric oxide complexes

US HEALTH102 citations98
US5366997ANov 22, 1994

Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs

US HEALTH167 citations98
US6887485B2May 3, 2005

Nitric oxide-releasing metallic medical devices

US HEALTH140 citations97
US6379660B1Apr 30, 2002

Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same

US HEALTH105 citations97
US5714511AFeb 3, 1998

Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs

US HEALTH94 citations97
US5632981AMay 27, 1997

Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US HEALTH167 citations97
US5212204AMay 18, 1993

Antihypertensive compositions and use thereof

US HEALTH138 citations97
US5039705AAug 13, 1991

Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof

US HEALTH132 citations97
US7105502B2Sep 12, 2006

Nitric oxide-releasing imidate and thioimidate diazeniumdiolates

US HEALTH49 citations96
US6949530B2Sep 27, 2005

Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH47 citations96
US6911478B2Jun 28, 2005

Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH57 citations96
US6750254B2Jun 15, 2004

Nitric oxide-releasing amidine—and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH53 citations96
US6200558B1Mar 13, 2001

Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US HEALTH96 citations96
US5814656ASep 29, 1998

Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs

US HEALTH79 citations96
US5718892AFeb 17, 1998

Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US HEALTH87 citations96
US5650447AJul 22, 1997

Nitric oxide-releasing polymers to treat restenosis and related disorders

US HEALTH198 citations96
US5250550AOct 5, 1993

Complexes of nitric oxide with polyamines

US HEALTH95 citations96
US6290981B1Sep 18, 2001

Use of nitric oxide-releasing agents to treat impotency

US HEALTH76 citations95
US5208233AMay 4, 1993

Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof

US HEALTH66 citations95
US5389675AFeb 14, 1995

Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents

US HEALTH58 citations94
US7425218B2Sep 16, 2008

Nitric oxide-releasing medical devices

US HEALTH34 citations93
US6610660B1Aug 26, 2003

O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates

US HEALTH45 citations93
US7348319B2Mar 25, 2008

Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same

US HEALTH37 citations92
US7081524B2Jul 25, 2006

O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates

US HEALTH15 citations92
US6911433B2Jun 28, 2005

O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates

US HEALTH34 citations90
US5185376AFeb 9, 1993

Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof

US HEALTH38 citations87
US7928096B2Apr 19, 2011

Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same

US HEALTH14 citations80
US7468435B2Dec 23, 2008

Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same

US HEALTH16 citations80
US9540471B2Jan 10, 2017

Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof

US HEALTH4 citations73
US7968664B2Jun 28, 2011

Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof

US HEALTH3 citations59
US7807472B2Oct 5, 2010

Methods for separation and detection of ketosteroids and other carbonyl-containing compounds

US HEALTH6 citations58

USA

2 patents

MEDTRONIC AVE INC

1 patent

MEDTRONIC VASCULAR INC

1 patent

US ARMY

1 patent

HRABIE JOSEPH A

1 patent

Showing the top 50 of 53 patents by PatentIndex Score.