Inventor
KEEFER LARRY K
US53 patents
⚠️ This page may combine multiple inventors who share the name “KEEFER LARRY K”. Patents are grouped by organization below to help distinguish them — per-person disambiguation is on the roadmap.
US HEALTH
44 patentsUS6232336B1May 15, 2001
Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH115 citations99
US5814666ASep 29, 1998
Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US HEALTH320 citations99
US5691423ANov 25, 1997
Polysaccharide-bound nitric oxide-nucleophile adducts
US HEALTH160 citations99
US5676963AOct 14, 1997
Implants, prostheses, and stents comprising polymer-bound nitric oxide/nucleophile adducts capable of releasing nitric oxide
US HEALTH144 citations99
US5525357AJun 11, 1996
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US HEALTH258 citations99
US5405919AApr 11, 1995
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US HEALTH334 citations99
US5155137AOct 13, 1992
Complexes of nitric oxide with polyamines
US HEALTH176 citations99
US4954526ASep 4, 1990
Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US HEALTH196 citations99
US7928079B2Apr 19, 2011
Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
US HEALTH56 citations98
US6673338B1Jan 6, 2004
Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same
US HEALTH100 citations98
US6511991B2Jan 28, 2003
Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH97 citations98
US6110453AAug 29, 2000
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US HEALTH87 citations98
US5910316AJun 8, 1999
Use of nitric oxide-releasing agents to treat impotency
US HEALTH170 citations98
US5683668ANov 4, 1997
Method of generating nitric oxide gas using nitric oxide complexes
US HEALTH102 citations98
US5366997ANov 22, 1994
Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US HEALTH167 citations98
US6887485B2May 3, 2005
Nitric oxide-releasing metallic medical devices
US HEALTH140 citations97
US6379660B1Apr 30, 2002
Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same
US HEALTH105 citations97
US5714511AFeb 3, 1998
Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US HEALTH94 citations97
US5632981AMay 27, 1997
Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US HEALTH167 citations97
US5212204AMay 18, 1993
Antihypertensive compositions and use thereof
US HEALTH138 citations97
US5039705AAug 13, 1991
Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US HEALTH132 citations97
US7105502B2Sep 12, 2006
Nitric oxide-releasing imidate and thioimidate diazeniumdiolates
US HEALTH49 citations96
US6949530B2Sep 27, 2005
Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH47 citations96
US6911478B2Jun 28, 2005
Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH57 citations96
US6750254B2Jun 15, 2004
Nitric oxide-releasing amidine—and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH53 citations96
US6200558B1Mar 13, 2001
Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US HEALTH96 citations96
US5814656ASep 29, 1998
Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs
US HEALTH79 citations96
US5718892AFeb 17, 1998
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US HEALTH87 citations96
US5650447AJul 22, 1997
Nitric oxide-releasing polymers to treat restenosis and related disorders
US HEALTH198 citations96
US5250550AOct 5, 1993
Complexes of nitric oxide with polyamines
US HEALTH95 citations96
US6290981B1Sep 18, 2001
Use of nitric oxide-releasing agents to treat impotency
US HEALTH76 citations95
US5208233AMay 4, 1993
Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US HEALTH66 citations95
US5389675AFeb 14, 1995
Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
US HEALTH58 citations94
US7425218B2Sep 16, 2008
Nitric oxide-releasing medical devices
US HEALTH34 citations93
US6610660B1Aug 26, 2003
O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates
US HEALTH45 citations93
US7348319B2Mar 25, 2008
Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
US HEALTH37 citations92
US7081524B2Jul 25, 2006
O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
US HEALTH15 citations92
US6911433B2Jun 28, 2005
O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates
US HEALTH34 citations90
US5185376AFeb 9, 1993
Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof
US HEALTH38 citations87
US7928096B2Apr 19, 2011
Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
US HEALTH14 citations80
US7468435B2Dec 23, 2008
Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
US HEALTH16 citations80
US9540471B2Jan 10, 2017
Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof
US HEALTH4 citations73
US7968664B2Jun 28, 2011
Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US HEALTH3 citations59
US7807472B2Oct 5, 2010
Methods for separation and detection of ketosteroids and other carbonyl-containing compounds
US HEALTH6 citations58
USA
2 patentsMEDTRONIC AVE INC
1 patentMEDTRONIC VASCULAR INC
1 patentUS ARMY
1 patentHRABIE JOSEPH A
1 patentShowing the top 50 of 53 patents by PatentIndex Score.