Inventor

RAVIKUMAR VASULINGA T

US34 patents

Patents

34 patents

US7041816B2May 9, 2006

Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents

ISIS PHARMACEUTICALS INC116 citations98

US7273933B1Sep 25, 2007

Methods for synthesis of oligonucleotides

ISIS PHARMACEUTICALS INC218 citations97

US6465628B1Oct 15, 2002

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC82 citations97

US6846922B1Jan 25, 2005

Activators for oligonucleotide synthesis

ISIS PHARMACEUTICALS INC56 citations96

US6642373B2Nov 4, 2003

Activators for oligonucleotide synthesis

ISIS PHARMACEUTICALS INC66 citations96

US6242591B1Jun 5, 2001

Synthesis of sulfurized 2'-substituted oligonucleotides

ISIS PHARMACEUTICALS INC45 citations96

US6051699AApr 18, 2000

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC74 citations96

US5760209AJun 2, 1998

Protecting group for synthesizing oligonucleotide analogs

ISIS PHARMACEUTICALS INC72 citations96

US5705621AJan 6, 1998

Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same

ISIS PHARMACEUTICALS INC78 citations96

US6649750B1Nov 18, 2003

Process for the preparation of oligonucleotide compounds

ISIS PHARMACEUTICALS INC26 citations92

US6326478B1Dec 4, 2001

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC33 citations92

US6114519ASep 5, 2000

Synthesis of sulfurized oligonucleotides

ISIS PHARMACEUTICALS INC40 citations92

US5959099ASep 28, 1999

Protecting group for synthesizing oligonucleotide analogs

ISIS PHARMACEUTICALS INC21 citations92

US7227015B2Jun 5, 2007

Synthesis of sulfurized oligonucleotides

ISIS PHARMACEUTICALS INC11 citations84

US6586586B1Jul 1, 2003

Purification of oligonucleotides

ISIS PHARMACEUTICALS INC13 citations82

US5902881AMay 11, 1999

Reagent useful for synthesizing sulfurized oligonucleotide analogs

ISIS PHARMACEUTICALS INC14 citations82

US5783690AJul 21, 1998

Protecting group for synthesizing oligonucleotide analogs

ISIS PHARMACEUTICALS INC16 citations82

US6335439B1Jan 1, 2002

Method of preparing phosphoramidites

ISIS PHARMACEUTICALS INC19 citations79

US7378516B2May 27, 2008

Synthesis of sulfurized oligonucleotides

ISIS PHARMACEUTICALS INC8 citations74

US6677471B2Jan 13, 2004

Intermediates for the synthesis of oligonucleotide analogues

ISIS PHARMACEUTICALS INC4 citations74

US6610842B1Aug 26, 2003

Processes for the synthesis of oligomers using phosphoramidite compositions

ISIS PHARMACEUTICALS INC9 citations74

US6521775B2Feb 18, 2003

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC4 citations74

US6399756B1Jun 4, 2002

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC6 citations74

US6160152ADec 12, 2000

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC9 citations74

US5859232AJan 12, 1999

Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds

ISIS PHARMACEUTICALS INC10 citations74

US7199236B2Apr 3, 2007

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC8 citations73

US6103891AAug 15, 2000

Method for the synthesis of nucleotide or oligonucleotide phosphoramidites

ISIS PHARMACEUTICALS INC2 citations63

US6040438AMar 21, 2000

Reagent useful for synthesizing sulfurized oligonucleotide analogs

ISIS PHARMACEUTICALS INC2 citations63

US7227016B2Jun 5, 2007

Process for the synthesis of oligomeric compounds

ISIS PHARMACEUTICALS INC1 citations62

US6858722B2Feb 22, 2005

Oligomer phosphoramidite compositions and processes for synthesizing the same

ISIS PHARMACEUTICALS INC1 citations52

US6399831B1Jun 4, 2002

Reagent useful for synthesizing sulfurized oligonucleotide analogs

ISIS PHARMACEUTICALS INC0 citations52

RAVIKUMAR VASULINGA T

Patents

Process for the synthesis of oligomeric compounds

Process for the synthesis of oligomeric compounds

Process for the synthesis of oligomeric compounds

Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents

Methods for synthesis of oligonucleotides

Process for the synthesis of oligomeric compounds

Activators for oligonucleotide synthesis

Activators for oligonucleotide synthesis

Synthesis of sulfurized 2&#39;-substituted oligonucleotides

Process for the synthesis of oligomeric compounds

Protecting group for synthesizing oligonucleotide analogs

Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same

Process for the preparation of oligonucleotide compounds

Process for the synthesis of oligomeric compounds

Synthesis of sulfurized oligonucleotides

Protecting group for synthesizing oligonucleotide analogs

Synthesis of sulfurized oligonucleotides

Purification of oligonucleotides

Reagent useful for synthesizing sulfurized oligonucleotide analogs

Protecting group for synthesizing oligonucleotide analogs

Method of preparing phosphoramidites

Synthesis of sulfurized oligonucleotides

Intermediates for the synthesis of oligonucleotide analogues

Processes for the synthesis of oligomers using phosphoramidite compositions

Process for the synthesis of oligomeric compounds

Process for the synthesis of oligomeric compounds

Process for the synthesis of oligomeric compounds

Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds

Process for the synthesis of oligomeric compounds

Method for the synthesis of nucleotide or oligonucleotide phosphoramidites

Reagent useful for synthesizing sulfurized oligonucleotide analogs

Process for the synthesis of oligomeric compounds

Oligomer phosphoramidite compositions and processes for synthesizing the same

Reagent useful for synthesizing sulfurized oligonucleotide analogs

Synthesis of sulfurized 2'-substituted oligonucleotides