Inventor · disambiguated record
Michael Heartlein
Also filed as: HEARTLEIN MICHAEL · HEARTLEIN MICHAEL W
176 granted patents·92 pending applications·3,142 citations·filing 1994–2025
99Inventor score
Files withTRANSLATE BIO INC192SHIRE HUMAN GENETIC THERAPIES26TRANSKARYOTIC THERAPIES INC26GUILD BRAYDON CHARLES4SYNAGEVA BIOPHARMA CORP2
Top patents by PatentIndex Score
268 records- 0199US11291734B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2021·Granted Apr 5, 2022·10 cites·24 claims
- 0299US11185595B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2021·Granted Nov 30, 2021·7 cites·18 claims
- 0399US11052159B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2020·Granted Jul 6, 2021·10 cites·19 claims
- 0499US10888626B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2020·Granted Jan 12, 2021·13 cites·22 claims
- 0599US10238754B2Lipid nanoparticle compositions and methods for MRNA deliveryTRANSLATE BIO INC·Filed 2017·Granted Mar 26, 2019·35 cites·13 claims
- 0698US11820977B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2022·Granted Nov 21, 2023·3 cites·18 claims
- 0798US11692189B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2022·Granted Jul 4, 2023·3 cites·14 claims
- 0898US11547764B2Lipid nanoparticle compositions and methods for MRNA deliveryTRANSLATE BIO INC·Filed 2021·Granted Jan 10, 2023·2 cites·13 claims
- 0998US11338044B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2021·Granted May 24, 2022·5 cites·21 claims
- 1098US10507249B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2019·Granted Dec 17, 2019·19 cites·20 claims
- 1198US10471153B2Ice-based lipid nanoparticle formulation for delivery of mRNATRANSLATE BIO INC·Filed 2017·Granted Nov 12, 2019·15 cites·6 claims
- 1298US10413618B2Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2018·Granted Sep 17, 2019·26 cites·22 claims
- 1398US10350303B1Lipid nanoparticle compositions and methods for mRNA deliveryTRANSLATE BIO INC·Filed 2019·Granted Jul 16, 2019·24 cites·22 claims
- 1498US10022455B2Biodegradable lipids for delivery of nucleic acidsTRANSLATE BIO INC·Filed 2015·Granted Jul 17, 2018·17 cites·7 claims
- 1598US9850269B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2015·Granted Dec 26, 2017·54 cites·19 claims
- 1698US9308281B2MRNA therapy for Fabry diseaseSHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Apr 12, 2016·40 cites·8 claims
- 1798US9061021B2mRNA for use in treatment of human genetic diseasesSHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Jun 23, 2015·43 cites·14 claims
- 1898US8853377B2mRNA for use in treatment of human genetic diseasesGUILD BRAYDON CHARLES·Filed 2011·Granted Oct 7, 2014·138 cites·14 claims
- 1998US6670178B1In Vivo production and delivery of insulinotropin for gene therapyTRANSKARYOTIC THERAPIES INC·Filed 2000·Granted Dec 30, 2003·105 cites·11 claims
- 2098US5733761AProtein production and protein deliveryTRANSKARYOTIC THERAPIES INC·Filed 1995·Granted Mar 31, 1998·317 cites·70 claims
- 2197US11234936B2Cleavable lipidsTRANSLATE BIO INC·Filed 2020·Granted Feb 1, 2022·4 cites·18 claims
- 2297US11059841B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2018·Granted Jul 13, 2021·16 cites·18 claims
- 2397US10940207B2Ice-based lipid nanoparticle formulation for delivery of mRNATRANSLATE BIO INC·Filed 2020·Granted Mar 9, 2021·4 cites·16 claims
- 2497US10208295B2MRNA therapy for phenylketonuriaTRANSLATE BIO INC·Filed 2016·Granted Feb 19, 2019·22 cites·3 claims
- 2597US10155785B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2017·Granted Dec 18, 2018·22 cites·16 claims
- 2697US10137087B2Lipid-derived neutral nanoparticlesTRANSLATE BIO INC·Filed 2018·Granted Nov 27, 2018·12 cites·22 claims
- 2797US9956271B2mRNA for use in treatment of human genetic diseasesTRANSLATE BIO INC·Filed 2015·Granted May 1, 2018·11 cites·9 claims
- 2897US9877919B2Lipid-derived neutral nanoparticlesTRANSLATE BIO INC·Filed 2013·Granted Jan 30, 2018·22 cites·15 claims
- 2997US9629804B2Lipid formulations for delivery of messenger RNASHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Apr 25, 2017·60 cites·18 claims
- 3097US9522176B2MRNA therapy for phenylketonuriaSHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Dec 20, 2016·38 cites·12 claims
- 3197US9181321B2CFTR mRNA compositions and related methods and usesSHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Nov 10, 2015·50 cites·18 claims
- 3297US6048729AIn vivo protein production and delivery system for gene therapyTRANSKARYOTIC THERAPIES INC·Filed 1994·Granted Apr 11, 2000·74 cites·28 claims
- 3397US5641670AProtein production and protein deliveryTRANSKARYOTIC THERAPIES INC·Filed 1994·Granted Jun 24, 1997·502 cites·30 claims
- 3496US10959953B2Lipid formulations for delivery of messenger RNATRANSLATE BIO INC·Filed 2019·Granted Mar 30, 2021·10 cites·24 claims
- 3596US10876104B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2018·Granted Dec 29, 2020·6 cites·26 claims
- 3696US10702478B2Cleavable lipidsTRANSLATE BIO INC·Filed 2019·Granted Jul 7, 2020·7 cites·3 claims
- 3796US10286083B2Biodegradable lipids for delivery of nucleic acidsTRANSLATE BIO INC·Filed 2018·Granted May 14, 2019·6 cites·7 claims
- 3896US10143758B2Liver specific delivery of messenger RNATRANSLATE BIO INC·Filed 2013·Granted Dec 4, 2018·28 cites·30 claims
- 3996US10052284B2Lipid formulations for delivery of messenger RNATRANSLATE BIO INC·Filed 2017·Granted Aug 21, 2018·20 cites·9 claims
- 4096US9713626B2CFTR mRNA compositions and related methods and usesSHIRE HUMAN GENETIC THERAPIES·Filed 2015·Granted Jul 25, 2017·23 cites·19 claims
- 4196US9597413B2Pulmonary delivery of mRNASHIRE HUMAN GENETIC THERAPIES·Filed 2014·Granted Mar 21, 2017·17 cites·6 claims
- 4295US11920182B2Quantitative assessment for cap efficiency of messenger RNATRANSLATE BIO INC·Filed 2021·Granted Mar 5, 2024·2 cites·13 claims
- 4395US11884692B2Methods for purification of messenger RNATRANSLATE BIO INC·Filed 2022·Granted Jan 30, 2024·1 cites·16 claims
- 4495US10786455B2Lipid-derived neutral nanoparticlesTRANSLATE BIO INC·Filed 2018·Granted Sep 29, 2020·5 cites·18 claims
- 4595US10646504B2Synergistic enhancement of the delivery of nucleic acids via blended formulationsTRANSLATE BIO INC·Filed 2018·Granted May 12, 2020·8 cites·14 claims
- 4695US10493166B2Biodegradable lipids for delivery of nucleic acidsTRANSLATE BIO INC·Filed 2018·Granted Dec 3, 2019·5 cites·13 claims
- 4795US10293057B2Biodegradable lipids for delivery of nucleic acidsTRANSLATE BIO INC·Filed 2018·Granted May 21, 2019·5 cites·7 claims
- 4895US10286082B2Biodegradable lipids for delivery of nucleic acidsTRANSLATE BIO INC·Filed 2018·Granted May 14, 2019·5 cites·7 claims
- 4995US10144942B2Modification of RNA-related enzymes for enhanced productionTRANSLATE BIO INC·Filed 2016·Granted Dec 4, 2018·10 cites·1 claims
- 5095US10137086B2Lipid-derived neutral nanoparticlesTRANSLATE BIO INC·Filed 2018·Granted Nov 27, 2018·6 cites·18 claims
Showing the top 50 of 268 patent records by PatentIndex Score.
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Identity basis: PatentsView inventor disambiguation (2025Q4-odp release). How scoring works →