Topic leaderboard
Therapeutic activity of chemical compounds
Ranked by the PatentIndex Score — a 1–99 percentile within A61P · public-visibility date · generated 2026
top 25 per window · public-visibility date
Rising· last 2 yrs
Inventors whose newest A61P patents became public in the last 2 years — the current frontier
- 199Leonard G. Presta178 patents · 29,660 citations
- 296Muthiah Manoharan158 patents · 12,773 citations
- 392Alan J. Korman87 patents · 8,149 citations
- 488Mahesh V. Patel56 patents · 6,248 citations
- 583Mark J. Selby70 patents · 6,375 citations
- 679Feng Zhang52 patents · 5,096 citations
- 775Sayda M. Elbashir46 patents · 3,213 citations
- 871Guangping Gao80 patents · 4,488 citations
- 967Peter D. Senter43 patents · 4,876 citations
- 1063Svetlana O. Doronina29 patents · 3,971 citations
- 1158Carl H. June100 patents · 4,109 citations
- 1254H. Michael Shepard45 patents · 3,468 citations
- 1350Erik Verner88 patents · 4,292 citations
- 1446Nils Lonberg42 patents · 5,647 citations
- 1542Vernon G. Wong36 patents · 3,421 citations
- 1638Kallanthottathil G. Rajeev132 patents · 5,133 citations
- 1733Stephen F. Badylak37 patents · 5,799 citations
- 1829Hui Li177 patents · 4,836 citations
- 1925Ankush Argade99 patents · 3,806 citations
- 2021Ravi V. J. Chari90 patents · 5,704 citations
- 2117Eric E. Swayze112 patents · 5,740 citations
- 2213Punit P. Seth69 patents · 4,684 citations
- 238Ian Maclachlan35 patents · 4,440 citations
- 244Antonin De Fougerolles85 patents · 3,514 citations
- 251Derek Jantz42 patents · 2,174 citations
Active· last 5 yrs
Sustained A61P output across the last 5 years
- 199Leonard G. Presta178 patents · 29,660 citations
- 296Paul Carter37 patents · 15,897 citations
- 392Casey C. Case23 patents · 4,927 citations
- 488James D. Marks52 patents · 5,467 citations
- 583Hendricus Renerus Jacobus Mattheus Hoogenboom22 patents · 5,212 citations
- 679Muthiah Manoharan158 patents · 12,773 citations
- 775Alan J. Korman87 patents · 8,149 citations
- 871Mahesh V. Patel56 patents · 6,248 citations
- 967Feng-Jing Chen24 patents · 5,794 citations
- 1063Arthur M. Krieg52 patents · 7,293 citations
- 1158Mohan Srinivasan65 patents · 6,452 citations
- 1254Mark J. Selby70 patents · 6,375 citations
- 1350Changyu Wang27 patents · 5,869 citations
- 1446James M. Wilson120 patents · 6,238 citations
- 1542Louis Fries10 patents · 3,343 citations
- 1638Feng Zhang52 patents · 5,096 citations
- 1733Sayda M. Elbashir46 patents · 3,213 citations
- 1829Guangping Gao80 patents · 4,488 citations
- 1925Mauricio R. Alvira35 patents · 2,978 citations
- 2021Peter D. Senter43 patents · 4,876 citations
- 2117Svetlana O. Doronina29 patents · 3,971 citations
- 2213Carl H. June100 patents · 4,109 citations
- 238Michael C. Milone36 patents · 3,207 citations
- 244Michael D. Kalos22 patents · 3,096 citations
- 251Bruce L. Levine32 patents · 3,087 citations
All-time canon
Career PatentIndex Score in A61P
- 199Cary L. Queen12 patents · 26,158 citations
- 296Harold E. Selick7 patents · 25,683 citations
- 392Leonard G. Presta178 patents · 29,660 citations
- 488Paul Carter37 patents · 15,897 citations
- 583Casey C. Case23 patents · 4,927 citations
- 679George N. Cox, Iii41 patents · 4,715 citations
- 775Eric Jarvis13 patents · 4,299 citations
- 871Stephen P. Eisenberg13 patents · 4,299 citations
- 967Sharon Kaye Spratt8 patents · 3,914 citations
- 1063James D. Marks52 patents · 5,467 citations
- 1158John Mccafferty15 patents · 5,369 citations
- 1254Hendricus Renerus Jacobus Mattheus Hoogenboom22 patents · 5,212 citations
- 1350Gregory Paul Winter18 patents · 5,159 citations
- 1446Geoffrey Walter Grigg10 patents · 4,903 citations
- 1542Andrew David Griffiths7 patents · 4,880 citations
- 1638Muthiah Manoharan158 patents · 12,773 citations
- 1733Alan J. Korman87 patents · 8,149 citations
- 1829John B. Ridgway7 patents · 5,694 citations
- 1925Mahesh V. Patel56 patents · 6,248 citations
- 2021Feng-Jing Chen24 patents · 5,794 citations
- 2117Arthur M. Krieg52 patents · 7,293 citations
- 2213Mohan Srinivasan65 patents · 6,452 citations
- 238Mark J. Selby70 patents · 6,375 citations
- 244Changyu Wang27 patents · 5,869 citations
- 251Benjamin Oshlack128 patents · 11,069 citations
Rising· last 2 yrs
The top-scoring A61P patents made public in the last 2 years
- 199US11883373B1✦ AITreatment of depression in certain patient populations30 cites · 202472% earned
- 296US11925636B2✦ AIBupropion dosage forms with reduced food and alcohol dosing effects28 cites · 202475% earned
- 392US12097263B2✦ AIMuscle targeting complexes and uses thereof for treating myotonic dystrophy18 cites · 202481% earned
- 488US12005124B2Muscle targeting complexes and uses thereof for treating dystrophinopathies23 cites · 202473% earned
- 583US12018087B2Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an o23 cites · 202477% earned
- 679US12156914B2Pharmaceutical compositions comprising bupropion and cysteine23 cites · 202477% earned
- 775US12012460B2Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an o22 cites · 202471% earned
- 871US11986444B2Treatment of poor metabolizers of dextromethorphan with a combination of bupropion and dex22 cites · 202480% earned
- 967US12491184B2Compositions and methods of use for modified release minoxidil7 cites · 202554% earned
- 1063US12144868B2Muscle targeting complexes and uses thereof for treating dystrophinopathies14 cites · 202475% earned
- 1158US11999947B2Adenosine nucleobase editors and uses thereof18 cites · 202477% earned
- 1254US12128109B2Muscle targeting complexes and formulations for treating dystrophinopathies17 cites · 202484% earned
- 1350US12268693B2Pharmaceutical compositions comprising a tolfenamic acid11 cites · 202478% earned
- 1446US12070459B2Pharmaceutical capsule compositions comprising lumateperone mono-tosylate16 cites · 202472% earned
- 1542US12138260B2Compounds and combinations thereof for treating neurological and psychiatric conditions16 cites · 202478% earned
- 1638US12128052B2Pharmaceutical compositions comprising meloxicam13 cites · 202470% earned
- 1733US12090155B2Methods13 cites · 202479% earned
- 1829US12005118B2Pharmaceutical compositions comprising meloxicam13 cites · 202483% earned
- 1925US12318397B1Methods and compositions for testosterone production4 cites · 202562% earned
- 2021US12329825B1Muscle targeting complexes comprising an anti-transferrin receptor antibody linked to an o4 cites · 202570% earned
- 2117US12447148B2Methods of improving lung function4 cites · 202582% earned
- 2213US12115145B2Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics10 cites · 202465% earned
- 238US12246023B2Use of reboxetine to treat narcolepsy10 cites · 202470% earned
- 244US12097175B2Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics9 cites · 202466% earned
- 251US12365669B2THRβ receptor agonist compound and preparation method and use thereof3 cites · 202559% earned
Active· last 5 yrs
The top-scoring A61P patents of the last 5 years
- 199US10953089B1✦ AICoronavirus vaccine formulations99 cites · 202183% earned
- 296US11191739B2✦ AIBupropion as a modulator of drug activity82 cites · 202193% earned
- 392US11147808B2✦ AIMethod of decreasing the fluctuation index of dextromethorphan82 cites · 202193% earned
- 488US11447770B1Methods and compositions for prime editing nucleotide sequences81 cites · 202278% earned
- 583US10925842B2Bupropion as a modulator of drug activity97 cites · 202193% earned
- 679US11197839B2Bupropion as a modulator of drug activity78 cites · 202193% earned
- 775US10980800B2Bupropion as a modulator of drug activity93 cites · 202193% earned
- 871US11253492B2Bupropion as a modulator of drug activity77 cites · 202193% earned
- 967US11298352B2Bupropion as a modulator of drug activity74 cites · 202193% earned
- 1063US11020389B2Bupropion as a modulator of drug activity87 cites · 202193% earned
- 1158US11291638B2Bupropion as a modulator of drug activity72 cites · 202193% earned
- 1254US11344544B2Bupropion as a modulator of drug activity71 cites · 202189% earned
- 1350US11291665B2Bupropion as a modulator of drug activity71 cites · 202193% earned
- 1446US11253491B2Bupropion as a modulator of drug activity71 cites · 202193% earned
- 1542US11207281B2Bupropion as a modulator of drug activity84 cites · 202193% earned
- 1638US11285118B2Bupropion as a modulator of drug activity69 cites · 202286% earned
- 1733US11229640B2Combination of dextromethorphan and bupropion for treating depression80 cites · 202193% earned
- 1829US11419867B2Bupropion as a modulator of drug activity66 cites · 202292% earned
- 1925US11123343B2Bupropion as a modulator of drug activity79 cites · 202193% earned
- 2021US11213521B2Bupropion as a modulator of drug activity79 cites · 202193% earned
- 2117US11111309B2Method of reducing expression of DUX4 in a muscle cell by administering an anti-transferri65 cites · 202177% earned
- 2213US11730706B1Treatment of depression in certain patient populations39 cites · 202373% earned
- 238US11141388B2Bupropion as a modulator of drug activity78 cites · 202189% earned
- 244US11426370B2Bupropion as a modulator of drug activity65 cites · 202192% earned
- 251US11058648B2Bupropion as a modulator of drug activity77 cites · 202193% earned
All-time canon
The defining A61P patents of the whole record
- 199US5585089A✦ AIHumanized immunoglobulins7,465 cites · 199690% earned
- 296US5530101A✦ AIHumanized immunoglobulins5,773 cites · 199690% earned
- 392US5693762A✦ AIHumanized immunoglobulins5,271 cites · 199790% earned
- 488US5821337AImmunoglobulin variants4,043 cites · 199891% earned
- 583US6180370B1Humanized immunoglobulins and methods of making the same3,646 cites · 200189% earned
- 679US6737056B1Polypeptide variants with altered effector function3,376 cites · 200487% earned
- 775US5693761APolynucleotides encoding improved humanized immunoglobulins3,290 cites · 199789% earned
- 871US4816397AMultichain polypeptides or proteins and processes for their production3,126 cites · 198996% earned
- 967US6506559B1Genetic inhibition by double-stranded RNA3,119 cites · 200387% earned
- 1063US5013556ALiposomes with enhanced circulation time2,874 cites · 199194% earned
- 1158US5770429ATransgenic non-human animals capable of producing heterologous antibodies2,663 cites · 199896% earned
- 1254US5731168AMethod for making heteromultimeric polypeptides2,644 cites · 199888% earned
- 1350US6054297AHumanized antibodies and methods for making them2,266 cites · 200096% earned
- 1446US8008449B2Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer u2,199 cites · 200987% earned
- 1542US6407213B1Method for making humanized antibodies2,158 cites · 200291% earned
- 1638US5539082APeptide nucleic acids2,083 cites · 199693% earned
- 1733US6544212B2Diabetes management system2,056 cites · 200396% earned
- 1829US4670417AHemoglobin combined with a poly(alkylene oxide)2,034 cites · 198796% earned
- 1925US4496689ACovalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer1,835 cites · 198596% earned
- 2021US6596296B1Drug releasing biodegradable fiber implant1,834 cites · 200392% earned
- 2117US6248363B1Solid carriers for improved delivery of active ingredients in pharmaceutical compositions1,826 cites · 200187% earned
- 2213US6602684B1Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxi1,819 cites · 200387% earned
- 238US5641870ALow pH hydrophobic interaction chromatography for antibody purification1,818 cites · 199789% earned
- 244US7108701B2Drug releasing anastomosis devices and methods for treating anastomotic sites1,784 cites · 200396% earned
- 251US6749587B2Modular infusion device and method1,768 cites · 200293% earned
Rising· last 2 yrs
Assignees whose newest A61P patents became public in the last 2 years — the current frontier
- 199GENENTECH INC1,383 patents · 60,723 citations
- 296LIPOCINE INC52 patents · 6,133 citations
- 392UNIV IOWA RES FOUND141 patents · 8,001 citations
- 488UNIV TEXAS927 patents · 20,041 citations
- 583UNIV PENNSYLVANIA634 patents · 13,492 citations
- 679US HEALTH1,266 patents · 28,710 citations
- 775AMGEN INC960 patents · 22,626 citations
- 871UNIV CALIFORNIA1,901 patents · 30,707 citations
- 967CHILDRENS MEDICAL CENTER259 patents · 7,651 citations
- 1063IMMUNOMEDICS INC226 patents · 11,272 citations
- 1158BRISTOL MYERS SQUIBB CO2,066 patents · 40,102 citations
- 1254IMMUNOGEN INC163 patents · 9,285 citations
- 1350PURDUE PHARMA LP381 patents · 8,617 citations
- 1446CELGENE CORP353 patents · 8,962 citations
- 1542BROAD INST INC120 patents · 3,413 citations
- 1638PURDUE RESEARCH FOUNDATION194 patents · 7,278 citations
- 1733RIGEL PHARMACEUTICALS INC264 patents · 4,427 citations
- 1829PFIZER2,457 patents · 43,131 citations
- 1925UNIV MASSACHUSETTS255 patents · 5,264 citations
- 2021UNIV ARIZONA154 patents · 7,233 citations
- 2117UNIV NEW YORK232 patents · 4,046 citations
- 2213SCRIPPS RESEARCH INST362 patents · 9,599 citations
- 238MILLENNIUM PHARM INC361 patents · 6,299 citations
- 244REGENERON PHARMA665 patents · 9,329 citations
- 251VERTEX PHARMA719 patents · 22,769 citations
Active· last 5 yrs
Sustained A61P output across the last 5 years
- 199GENENTECH INC1,383 patents · 60,723 citations
- 296LIPOCINE INC52 patents · 6,133 citations
- 392UNIV IOWA RES FOUND141 patents · 8,001 citations
- 488UNIV TEXAS927 patents · 20,041 citations
- 583UNIV PENNSYLVANIA634 patents · 13,492 citations
- 679WISCONSIN ALUMNI RES FOUND457 patents · 11,086 citations
- 775GLAUKOS CORP12 patents · 2,133 citations
- 871US HEALTH1,266 patents · 28,710 citations
- 967AMGEN INC960 patents · 22,626 citations
- 1063MAX PLANCK GESELLSCHAFT132 patents · 4,686 citations
- 1158UNIV CALIFORNIA1,901 patents · 30,707 citations
- 12543M INNOVATIVE PROPERTIES CO230 patents · 18,111 citations
- 1350CHILDRENS MEDICAL CENTER259 patents · 7,651 citations
- 1446IMMUNOMEDICS INC226 patents · 11,272 citations
- 1542BRISTOL MYERS SQUIBB CO2,066 patents · 40,102 citations
- 1638ETHICON INC51 patents · 5,533 citations
- 1733IMMUNOGEN INC163 patents · 9,285 citations
- 1829PURDUE PHARMA LP381 patents · 8,617 citations
- 1925CELGENE CORP353 patents · 8,962 citations
- 2021BROAD INST INC120 patents · 3,413 citations
- 2117PURDUE RESEARCH FOUNDATION194 patents · 7,278 citations
- 2213RIGEL PHARMACEUTICALS INC264 patents · 4,427 citations
- 238ALEXZA PHARMACEUTICALS INC73 patents · 4,579 citations
- 244WARNER LAMBERT CO636 patents · 23,110 citations
- 251PFIZER2,457 patents · 43,131 citations
All-time canon
All-time PatentIndex Score in A61P
- 199PROTEIN DESIGN LABS INC13 patents · 26,501 citations
- 296GENENTECH INC1,383 patents · 60,723 citations
- 392SANGAMO BIOSCIENCES INC67 patents · 6,793 citations
- 488ISIS PHARMACEUTICALS INC300 patents · 33,197 citations
- 583MEDICAL RES COUNCIL56 patents · 6,150 citations
- 679LIPOCINE INC52 patents · 6,133 citations
- 775UNIV IOWA RES FOUND141 patents · 8,001 citations
- 871MEDAREX INC67 patents · 10,134 citations
- 967UNIV TEXAS927 patents · 20,041 citations
- 1063UNIV PENNSYLVANIA634 patents · 13,492 citations
- 1158WISCONSIN ALUMNI RES FOUND457 patents · 11,086 citations
- 1254AMERICAN CYANAMID CO281 patents · 12,024 citations
- 1350EURO CELTIQUE SA145 patents · 15,354 citations
- 1446COLLAGEN CORP14 patents · 5,790 citations
- 1542CIBA GEIGY CORP460 patents · 15,521 citations
- 1638GLAUKOS CORP12 patents · 2,133 citations
- 1733US HEALTH1,266 patents · 28,710 citations
- 1829AMGEN INC960 patents · 22,626 citations
- 1925MAX PLANCK GESELLSCHAFT132 patents · 4,686 citations
- 2021UNIV CALIFORNIA1,901 patents · 30,707 citations
- 2117PHARMACYCLICS INC47 patents · 3,405 citations
- 2213SEATTLE GENETICS INC74 patents · 5,502 citations
- 2383M INNOVATIVE PROPERTIES CO230 patents · 18,111 citations
- 244ALEXZA MOLECULAR DELIVERY CORP20 patents · 2,255 citations
- 251IDEC PHARMA CORP25 patents · 4,719 citations
90–99 field-defining50–89 strong<50 emergingearned by citationsfrom family breadth