US10206899B2ActiveUtilityA1

Method for removing bacterial biofilms

Assignee: INFECTION ELIMINATION SERVICES LLCPriority: Aug 25, 2016Filed: Aug 25, 2016Granted: Feb 19, 2019

Est. expiryAug 25, 2036(~10.1 yrs left)· nominal 20-yr term from priority

Inventors:Charles F. Palmer, Jr.Thomas William Campbell, Jr.

A61K 31/255A61K 31/22A61K 31/225

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Claims

Abstract

A treatment mixture for treating biofilms on a human or animal is provided. The treatment mixture comprises: an effective amount of a salt of alkyleth sulfate defined by Formula I: R 1 —(OCHR 2 CH 2 ) n —OSO 3 X 1 Formula I wherein: R 1 is a branched or unbranched alkyl of 8-24 carbons; R 2 is hydrogen or methyl; n is an integer of 2 to 30; and each X 1 is independently a counter ion; an effective amount of at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II: R 4 OC(O)CH 2 SO 3 X 2 Formula II wherein R 4 is a branched or unbranched alkyl of 8-24 carbons; and X 2 is a counter ion; and an effective amount of a salt of an alkyl sulfosuccinate defined by Formula III: wherein: R 3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons; and X is a counter ion.

Claims

exact text as granted — not AI-modified

The invention claimed is:

1. A treatment mixture for treating biofilms on a human or animal comprising:
an effective amount of a salt of alkyleth sulfate defined by Formula I:
R 1 —(OCHR 2 CH 2 )n—OSO 3 X 1 Formula I

wherein:
R 1 is a branched or unbranched alkyl of 8-24 carbons;
R 2 is hydrogen or methyl;
n is an integer of 2 to 30; and
each X 1 is independently a counter ion;
an effective amount of at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II:
R 4 OC(O)CH 2 SO 3 X 2 Formula II

wherein R 4 is a branched or unbranched alkyl of 8-24 carbons; and
X 2 is a counter ion;
and an effective amount of a salt of an alkyl sulfosuccinate defined by Formula III:

wherein:
R 3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons;
X is a counter ion with the proviso that said treatment mixture does not comprise glucosides or phospholipids; and
comprising about 0.025-30% active ingredient in water.

2. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said R 1 comprises 10-18 carbons.

3. The treatment mixture for treating biofilms on a human or animal of claim 2 wherein said R 1 comprises 12-14 carbons.

4. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said n is an integer of preferably 4-10.

5. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said each X 1 is independently an alkali metal or ammonium.

6. The treatment mixture for treating biofilms on a human or animal of claim 5 wherein said each X 1 is independently selected from the group consisting of sodium and potassium and ammonium.

7. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said R 4 comprises 10-18 carbons.

8. The treatment mixture for treating biofilms on a human or animal of claim 7 wherein said R 4 comprises 12-14 carbons.

9. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said X 2 is an alkali metal or ammonium.

10. The treatment mixture for treating biofilms on a human or animal of claim 9 wherein said X 2 is selected from the group consisting of sodium and potassium and ammonium.

11. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said R 3 comprises 10-18 carbons.

12. The treatment mixture for treating biofilms on a human or animal of claim 11 wherein said R 3 comprises 12-14 carbons.

13. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said X is an alkali metal or ammonium.

14. The treatment mixture for treating biofilms on a human or animal of claim 13 wherein said X is selected from the group consisting of sodium and potassium and ammonium.

15. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said salt of alkylether sulfate is sodium laureth sulfate.

16. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said salt of alkyl sulfoacetate is disodium lauryl sulfoacetate.

17. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said salt of an alkyl sulfosuccinate is disodium lauryl sulfosuccinate.

18. The treatment mixture for treating biofilms on a human or animal of claim 1 comprising both said salt of alkyl sulfoacetate and said salt of an alkyl sulfosuccinate.

19. The treatment mixture for treating biofilms on a human or animal of claim 1 wherein said treatment mixture is selected from a liquid, a gel and a foam.

20. The treatment mixture for treating biofilms on a human or animal of claim 1 further comprising nonionic or amphoteric surfactants.

21. A method for the removal of bacterial biofilms comprising:
applying a treatment mixture to said biofilm wherein said treatment mixture comprises:
an effective amount of a salt of alkyleth sulfate defined by Formula I:
R 1 —(OCHR 2 CH 2 )n—OSO 3 X 1 Formula I

wherein:
R 1 is a branched or unbranched alkyl of 8-24 carbons;
R 2 is hydrogen or methyl;
n is an integer of 2 to 30; and
each X 1 is independently a counter ion;
an effective amount at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II:
R 4 OC(O)CH 2 SO 3 X 2 Formula II

wherein R 4 is a branched or unbranched alkyl of 8-24 carbons; and
X 2 is a counter ion;
and a salt of an alkyl sulfosuccinate defined by Formula III:

wherein:
R 3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons; and
X is a counter ion;
allowing said treatment mixture to remain in contact with said biofilm until dry;
rinsing with water; and
re-applying a treatment mixture to said biofilm.

22. The method for the removal of bacterial biofilms of claim 21 wherein said biofilm is integral to a bedsore.

23. The method for the removal of bacterial biofilms of claim 21 in which application of the surfactant solution to the wound is chosen from the group comprising a spray, soaking on a gauze pad, application of a gel, etc.

24. The method for the removal of bacterial biofilms of claim 21 wherein said R 1 comprises 10-18 carbons.

25. The method for the removal of bacterial biofilms of claim 24 wherein said R 1 comprises 12-14 carbons.

26. The method for the removal of bacterial biofilms of claim 21 wherein said n is an integer of preferably 4-10.

27. The method for the removal of bacterial biofilms of claim 21 wherein said each X 1 is independently an alkali metal or ammonium.

28. The method for the removal of bacterial biofilms of claim 27 wherein said each X 1 is independently selected from the group consisting of sodium and potassium and ammonium.

29. The method for the removal of bacterial biofilms of claim 21 wherein said R 4 comprises 10-18 carbons.

30. The method for the removal of bacterial biofilms of claim 21 wherein said X 2 is an alkali metal or ammonium.

31. The method for the removal of bacterial biofilms of claim 30 wherein said R 4 comprises 12-14 carbons.

32. The method for the removal of bacterial biofilms of claim 30 wherein said X 2 is selected from the group consisting of sodium and potassium and ammonium.

33. The method for the removal of bacterial biofilms of claim 21 wherein said R 3 comprises 10-18 carbons.

34. The method for the removal of bacterial biofilms of claim 33 wherein said R 3 comprises 12-14 carbons.

35. The method for the removal of bacterial biofilms of claim 21 wherein said X is an alkali metal or ammonium.

36. The method for the removal of bacterial biofilms of claim 35 wherein said X is selected from the group consisting of sodium and potassium and ammonium.

37. The method for the removal of bacterial biofilms of claim 21 wherein said salt of alkyleth sulfate is sodium laureth sulfate.

38. The method for the removal of bacterial biofilms of claim 21 wherein said salt of alkyl sulfoacetate is disodium lauryl sulfoacetate.

39. The method for the removal of bacterial biofilms of claim 21 wherein said salt of an alkyl sulfosuccinate is disodium lauryl sulfosuccinate.

40. The method for the removal of bacterial biofilms of claim 21 comprising both said salt of alkyl sulfoacetate and said salt of an alkyl sulfosuccinate.

41. The method for the removal of bacterial biofilms of claim 21 wherein said treatment mixture comprises about 0.025-30% active ingredient in water.

42. The method for the removal of bacterial biofilms of claim 21 wherein said treatment mixture is selected from a liquid, a gel and a foam.

43. The method for the removal of bacterial biofilms of claim 21 further comprising nonionic or amphoteric surfactants.

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