US10295547B2ActiveUtilityA1

Use and treatment of di-amino acid repeat-containing proteins associated with ALS

91
Assignee: UNIV FLORIDAPriority: Mar 14, 2013Filed: Mar 10, 2014Granted: May 21, 2019
Est. expiryMar 14, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Laura RanumTao Zu
A61P 21/02C07K 2317/34G01N 2800/285A61K 35/28G01N 2800/2835B01D 21/262C07K 16/18G01N 33/6896C12Q 1/6883C12Q 2600/158
91
PatentIndex Score
13
Cited by
39
References
3
Claims

Abstract

Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method of producing an antibody, the method comprising administering to a subject a poly-(Pro-Arg) di-amino acid repeat-containing protein. 
     
     
       2. The method of  claim 1 , wherein the poly-(Pro-Arg) di-amino acid repeat-containing protein comprises the sequence set forth in SEQ ID NO: 19. 
     
     
       3. The method of  claim 1 , further comprising the step of isolating the antibody from the subject.

Join the waitlist — get patent alerts

Track US10295547B2 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.