P
US10307353B2ActiveUtilityPatentIndex 50

1-phenylmono- or -polyhydroxypropane compounds, compositions and cosmetic uses thereof

Assignee: OREALPriority: Dec 12, 2014Filed: Dec 11, 2015Granted: Jun 4, 2019
Est. expiryDec 12, 2034(~8.4 yrs left)· nominal 20-yr term from priority
Inventors:DALKO MARIAHITCE JULIEN
A61P 17/00A61K 8/347A61K 8/34A61K 8/345C07C 43/23A61K 31/09A61K 31/085A61Q 19/08A61K 8/33
50
PatentIndex Score
0
Cited by
18
References
14
Claims

Abstract

The present invention relates to novel compounds of formula (I) to compositions comprising same, and also to the use thereof for preventing and/or cosmetically treating the signs of aging of the skin.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A process for retarding the onset of and/or reducing the signs of aging of the skin which comprises applying to the skin an effective amount for retarding the onset of and/or reducing the signs of aging of the skin of a composition comprising a physiologically acceptable medium and a compound of formula (I) 
       
         
           
           
               
               
           
         
         in which
 n=0; 1; 2 or 3 
 m=0; 1; 2 or 3 
 
         with 1≤m+n≤3
 R1 independently denotes a linear C1-C6 alkyl radical or a branched C3-C6 alkyl radical or a linear C1-C6 acyl radical, 
 R2 denotes a hydrogen atom and R3 denotes a hydrogen atom or an OH radical, an optical isomer, stereoisomer and/or diastereoisomer thereof and/or salt thereof 
 
         wherein the compound of formula (I) is present at a concentration of between 0.01% and 30% by weight relative to the total weight of the composition. 
       
     
     
       2. A process for retarding the onset of and/or reducing the signs of aging of the skin which comprises applying to the skin a composition comprising a physiologically acceptable medium and a compound of formula (I) 
       
         
           
           
               
               
           
         
         in which
 n=0; 1; 2 or 3 
 m=0; 1; 2 or 3 
 
         with 2≤m+n≤3
 R1 independently denotes a linear C1-C6 alkyl radical or a branched C3-C6 alkyl radical or a linear C1-C6 acyl radical, 
 R2 denotes a hydrogen atom and R3 denotes a hydrogen atom or an OH radical, an optical isomer, stereoisomer and/or diastereoisomer thereof and/or salt thereof 
 
         wherein the compound of formula (I) is present at a concentration of between 0.01% and 30% by weight relative to the total weight of the composition. 
       
     
     
       3. The process as claimed in  claim 1 , wherein, in the compound of formula (I):
   2≤ m+n≤ 3
 
 
       each of the substituents R1 independently denotes a linear C1-C4 alkyl radical. 
     
     
       4. The process as claimed in  claim 1 , wherein the compound of formula (I) is a compound of formula (II): 
       
         
           
           
               
               
           
         
         in which:
   2≤ m+n≤ 3.
 
 
       
     
     
       5. The process as claimed in  claim 4 , in which:
 each of the substituents R1 independently denotes a linear C1-C4 alkyl radical. 
 
     
     
       6. The process as claimed in  claim 1 , wherein the compound of formula (I) is chosen from compounds 1 to 4 below, the optical isomers, stereoisomers and diastereoisomers thereof and/or geometrical isomers thereof and/or salts thereof: 
       
         
           
                 
                 
                 
               
                     
                 
                   Compound 
                     
                   Structure 
                 
                     
                 
                   1 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   3 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   4 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
       7. The process as claimed in  claim 1 , wherein the compound of formula (I) is a compound of formula (III): 
       
         
           
           
               
               
           
         
         in which: 
         n=0; 1; 2 or 3 
         m=0; 1; 2 or 3 
         with 1≤m+n≤3
 each of the substituents R1 independently denotes a linear C1-C6 alkyl radical or a branched C3-C6 alkyl radical or a linear C2-C6 acyl radical. 
 
       
     
     
       8. The process as claimed in  claim 1 , wherein the compound of formula (I) is chosen from compounds 5 and 6 below, the optical isomers, stereoisomers and diastereoisomers thereof or geometrical isomers thereof and/or salts thereof: 
       
         
           
                 
                 
                 
               
                     
                 
                   Compound 
                     
                   Structure 
                 
                     
                 
                   5 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   6 
                     
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
             
                
                
                
               
               
                
                
                
                
               
            
           
         
       
     
     
       9. The process as claimed in  claim 1  which is a cosmetic treatment process for retarding the onset of and/or reducing the signs of aging of mature and/or wrinkled skin, characterized in that a compound of formula (I) or a composition containing it, is applied to the mature and/or wrinkled skin. 
     
     
       10. The cosmetic treatment process as claimed in  claim 9  which is intended for promoting the renewal of the keratinocytes and for retarding the onset of and/or reducing signs chosen from thinning of the epidermis, surface wrinkles and impairment of the barrier function. 
     
     
       11. The process as claimed in  claim 1 , wherein the signs on the skin are chosen from wrinkled skin, skin exhibiting impairment of its viscoelastic or biomechanical properties, skin exhibiting impairment in the cohesion of its tissues, thinned skin, and skin exhibiting impairment of its surface appearance. 
     
     
       12. The process as claimed in  claim 1 , wherein the compound of formula (I) is present, in a composition containing a physiologically acceptable medium, at a concentration of between 0.1% and 10% by weight relative to the total weight of the composition. 
     
     
       13. The process as claimed in  claim 1 , wherein the compound of formula (I) is present, in a composition containing a physiologically acceptable medium, at a concentration of between 0.5% and 5% by weight relative to the total weight of the composition. 
     
     
       14. The process as claimed in  claim 1 , wherein the compound of formula (I) is present, in a composition containing a physiologically acceptable medium, wherein the composition does not contain hydrogen peroxide.

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