US10343989B2ExpiredUtilityA1

Processes for the convergent synthesis of calicheamicin derivatives

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Assignee: WYETH LLCPriority: Feb 21, 2006Filed: Sep 28, 2017Granted: Jul 9, 2019
Est. expiryFeb 21, 2026(expired)· nominal 20-yr term from priority
Inventors:Justin Keith MoranJianxin Gu
A61P 35/00C07D 207/404C07D 405/14C07H 15/203C07D 207/46C07D 309/14C07H 15/26C07C 323/60C07C 319/20C07H 15/20
67
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Claims

Abstract

This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A compound selected from:
 butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide; and 
 butanoic acid,3-mercapto-3-methyl-,2-[(E)-1[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide. 
 
     
     
       2. A sodium salt of butanoic acid,3-mercapto-3 -methyl -,2-[(E)-1-[4-[4-[(2,5 -dioxo-1-pyrrolidinyl)oxy] -4-oxobutoxy]phenyl]ethylidene]hydrazide. 
     
     
       3. A sodium salt of butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide. 
     
     
       4. The compound of  claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide. 
     
     
       5. The compound of  claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide.

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