US10385069B2ActiveUtilityA1
Imidazo[2,1-B]thiazole and 5,6-dihydroimidazo[2,1-B]thiazole derivatives useful as S100-inhibitors

Assignee: ACTIVE BIOTECH ABPriority: Feb 3, 2015Filed: Dec 4, 2015Granted: Aug 20, 2019
Est. expiryFeb 3, 2035(~8.6 yrs left)· nominal 20-yr term from priority
Inventors:Ulf Wellmar Stephen Peter East Marie Bainbridge Colin H. Mackinnon James Lindsay Carr Jonathan David Hargrave
A61P 43/00A61P 37/02A61P 35/00A61P 29/00A61P 25/28C07D 513/04C07D 513/14A61K 31/429
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Claims
Abstract

A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful for use in the treatment of cancer, an inflammatory disorder, an autoimmunity disorder or a neurodegenerative disorder.
Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A compound of formula (I) 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein 
         b is an integer of from 0 to 4; 
         ring A is a 5- to 7-membered, aromatic or non-aromatic carbocycle or heterocycle; 
         Q is a direct bond, CH 2 , CH(OH) or NH; 
         R 1  is R 4 C(O), cyano, or tetrazolyl; 
         R 4  is H, R 5 O, or NHR 6 ; 
         R 5  is H or C1-C6 alkyl; 
         R 6  is cyano, C1-C6 alkyl, or R 7 S(O) 2 ; 
         R 7  is C1-C6 alkyl, C3-C6 cycloalkyl, R 8 (CH 2 ) y , or 5- or 6-membered aryl or heteroaryl, said aryl or heteroaryl optionally being substituted by one or more moieties independently selected from C1-C6 alkyl, 
         R 8  is R 9 O, R 10 R 11 N or R 12 OC(O); 
         R 9  is H or C1-C6 alkyl; 
         R 10  and R 11  are independently selected from H and C1-C6 alkyl, or R 10  and R 11 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; 
         R 12  is H or C1-C6 alkyl; 
         y is an integer from 1 to 4; 
         R 2  is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, halogen, cyano, R 13 R 14 N(CH 2 ) d , R 15 O(CH 2 ) e , R 16 S(CH 2 ) f , R 17 C(O)(CH 2 ) g , 
       
       
         
           
           
               
               
           
         
       
       or
 phenyl, optionally substituted by R 19 O(CH 2 ) i ; 
 R 13  is H, C1-C6 alkyl, R 20 C(O), R 21 S(O) 2 , R 22 O(CH 2 ) j , R 23 R 24 N(CH 2 ) k , or benzyl, and 
 R 14  is H or C1-C6 alkyl; or 
 R 13  and R 14 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring, said ring optionally being substituted by one or more substituents independently selected from oxo group, halogen, C1-C6 alkyl, R 25 C(O), R 26 OC(O), and R 27 O(CH 2 ) m , 
 R 15  is H, C1-C6 alkyl or R 28 C(O); 
 R 16  and R 17  are selected from H and C1-C6 alkyl; 
 R 18  is H, C1-C6 alkyl, R 29 OC(O)(CH 2 ) n , or R 30 S(O) 2 (CH 2 ) p ; 
 R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29  and R 30  are selected from H and C1-C6 alkyl; 
 ring B is 4- to 6-membered, and saturated or unsaturated; 
 d, e, f, g, h, i, j, k, m, n, and p are integers of from 0 to 4; 
 R′ 1  and R′ 2  together form a bond; or 
 R′ 1  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) q , or R 31 O(CH 2 ) r ; and R′ 2  is H; 
 R 31  is H or C1-C6 alkyl; 
 q and r are integers of from 0 to 4; and 
 each R 3  is independently selected from C1-C6 alkyl, C3-C6 carbocyclyl, halogen, oxo, R 32 O, R 33 S, and R 34 R 35 N; 
 R 32  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) s , or R 36 R 37 N(CH 2 ) t ; 
 R 33  is H or C1-C6 alkyl; 
 R 34  and R 35  are independently selected from H and C1-C6 alkyl; or R 34  and R 35 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring optionally substituted by one or more halogen; 
 R 36  and R 37  are independently selected from H and C1-C6 alkyl, or R 36  and R 37 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; optionally substituted by one or more halogen; 
 s and t are integers of from 0 to 4; 
 and 
 two R 3  attached to adjacent atoms of ring A, together with the atoms to which they are attached, may form a 3- to 6 membered ring, said ring being optionally substituted by one or more C1-C6 alkyl; 
 any alkyl, alkenyl and cycloalkyl is optionally substituted by one or more F; 
 provided that the compound is not 
 9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,11-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,12-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 11-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-oxo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 ethyl 2-{7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 2-{10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 2-{10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 2-{11-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 2-{7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{11-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 ethyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-ethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 methyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 propyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 isopropyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 7-thia-2,5-diazatricyclo[6.4.0.02,6]dodeca-1(8),3,5,9,11-pentaene-4-carbaldehyde, 
 10-ethyl-7-thia-2,5-diazatricyclo[6.4.0.02,6]dodeca-1(8),3,5,9,11-pentaene-4-carbaldehyde, 
 16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene-13-carboxylic acid, 
 2-{16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-13-yl}acetic acid, 
 ethyl 16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene-13-carboxylate, 
 ethyl 2-{16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-13-yl}acetate, 
 ethyl 10-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 2-{10-trifluoromethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 ethyl 2-{10-trifluoromethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 2-{10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 2-{10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, or 
 ethyl 2-{10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate. 
 
     
     
       2. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein ring A is a 5- to 7-membered, aromatic or non-aromatic carbocycle. 
     
     
       3. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein ring A is 6-membered. 
     
     
       4. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein ring A is benzene. 
     
     
       5. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein Q is a direct bond. 
     
     
       6. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1  is R 4 C(O). 
     
     
       7. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4  is R 5 O or NHR 6 . 
     
     
       8. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4  is R 5 O. 
     
     
       9. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2  is H, R 13 R 14 N(CH 2 ) d  or 
       
         
           
           
               
               
           
         
       
     
     
       10. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2  is H or R 13 R 14 N(CH 2 ) d . 
     
     
       11. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2  is H. 
     
     
       12. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R′ 1  and R′ 2  together form a bond. 
     
     
       13. A compound according to  claim 1 , selected from
 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-chloro-9-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5,9,11-pentaene-4-carboxylic acid, 
 3-bromo-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-(tert-butylamino)-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 2-{9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 N-methanesulfonyl-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-methanesulfonyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-(cyclopropanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-(2-methoxyethanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-(ethanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-(2,2,2-trifluoroethanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-trifluoromethanesulfonyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 methyl 3-[({9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}formamido)sulfonyl]propanoate 
 9,10-dichloro-N-(3-hydroxypropanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,10-dichloro-N-[3-(diethylamino)propanesulfonyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 2-{9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}-N-methanesulfonylacetamide, 
 9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10,10-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-phenyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 4,4,5,5-tetramethyl-7-thia-1,9-diazatricyclo[6.3.0.0 2,6 ]undeca-2(6), 8,10-triene-10-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.5.0.0 2,6 ]trideca-1(8),3,5-triene-4-carboxylic acid, 
 11,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylic acid, 
 9-hydroxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-(tert-butylamino)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 16-thia-11,14-diazatetracyclo[8.6.0.0 2 , 7 0.0 11 , 15 ]hexadeca-1(10),2(7),3,5,12,14-hexaene-13-carboxylic acid, 
 3-(benzylamino)-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,9-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 2-{10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-trien-4-yl}acetic acid, 
 2-{9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-trien-4-yl}acetic acid, 
 10-tert-butyl-N-methanesulfonyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 N-methanesulfonyl-9-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 N-methanesulfonyl-11,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 10-tert-butyl-N-[3-(morpholin-4-yl)propanesulfonyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 N-methanesulfonyl-4,4,5,5-tetramethyl-7-thia-1,9-diazatricyclo[6.3.0.0 2,6 ]undeca-2(6), 8,10-triene-10-carboxamide, 
 N-methanesulfonyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 N-[3-(diethylamino)propanesulfonyl]-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.02,6]dodeca-1(8),3,5-triene-4-carboxamide, 
 9,9,11,11-tetramethyl-N-[3-(morpholin-4-yl)propanesulfonyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 4,4,5,5-tetramethyl-N-[3-(morpholin-4-yl)propanesulfonyl]-7-thia-1,9-diazatricyclo[6.3.0.0 2,6 ]undeca-2(6),8,10-triene-10-carboxamide, 
 11,11-dimethyl-N-(2,2,2-trifluoroethanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 10-tert-butyl-N-cyano-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 ethyl 9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-chloro-9-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10,11-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 11-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-trifluoromethoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-bromo-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-(tert-butylamino)-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 2-{9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.02,6]dodeca-1(8),3,5,9,11-pentaen-4- 
 ethyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10,10-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-phenyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 4,4,5,5-tetramethyl-7-thia-1,9-diazatricyclo[6.3.0.0 2,6 ]undeca-2(6),8,10-triene-10-carboxylate, 
 ethyl 7-thia-2,5-diazatricyclo[6.5.0.0 2,6 ]trideca-1(8),3,5-triene-4-carboxylate, 
 ethyl 11,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-oxo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-hydroxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-(tert-butylam ino)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2(7),3,5,12,14-hexaene-13-carboxylate, 
 ethyl 3-(benzylamino)-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9,9-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 10-tert-butyl-N-(3-chloropropanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 9,10-dichloro-N-(3-chloropropanesulfonyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carbaldehyde 
 methyl 2-hydroxy-2-{9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-trien-4-yl}acetate, 
 ethyl 9,9,11,11-tetramethyl-10-oxa-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 2-{9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}-2-hydroxyacetate, 
 ethyl 3-bromo-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-(4-methoxyphenyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylate, 
 ethyl 10,10-dimethyl-7-thia-2,5-diazatetracyclo[6.4.0.0 2,6 0.0 9,11 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-amino-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-acetamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-methanesulfonamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylate, 
 ethyl 9,12-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 [ethyl 9-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-iodo-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxamide, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carbonitrile, 
 ethyl 10-[(trifluoromethyl)sulfanyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-(methylsulfanyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9,11-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-chloro-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-hydroxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-(benzyloxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9,10-difluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-(cyclopentyloxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 11-chloro-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-chloro-9-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-methanesulfonamido-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca1(8),3,5-triene-4-carboxylate, 
 ethyl 9-(pyrrolidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 2-{9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetate, 
 ethyl 3-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 methyl 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-bromo-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-ethynyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-chloro-11-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 3-bromo-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-methanesulfonamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl (4S)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl (4R)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-bromo-9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 9,10-dichloro-12-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-tert-butyl-3-(morpholin-4-ylmethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-bromo-9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-tert-butyl-3-[(2-oxopiperidin-1-yl)methyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3,9,9,11,11-pentamethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(morpholin-4-ylmethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-(2-methoxyphenyl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-chloro-10-(pyrrolidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-tert-butyl-3-{[(2-methoxyethyl)(methyl)amino]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-chloro-10-cyclopropyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-(4-methoxyphenyl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-(acetamidomethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-[(acetyloxy)methyl]-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-{[methoxy(methyl)amino]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-cyclopropyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 tert-butyl 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 9-chloro-10-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9,10-dichloro-11-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-({4-[(tert-butoxy)carbonyl]piperazin-1-yl}methyl)-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-{[4-(2-methoxyethyl)piperazin-1-yl]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 10-tert-butyl-3-[(4-methylpiperazin-1-yl)methyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-[(4-acetylpiperazin-1-yl)methyl]-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-{[2-(pyrrolidin-1-yl)ethyl]amino}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 3-(dimethylamino)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 3-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 ethyl 3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(piperazin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-(1,2,3,6-tetrahydropyridin-4-yl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-(4-acetylpiperazin-1-yl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9,10-dichloro-11-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(prop-1-en-2-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(4-methylpiperazin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 ethyl 3-(azetidin-3-yl)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-10-fluoro-3-(1-methylazetidin-3-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9-chloro-3-cyclopropyl-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 9,9,11,11-tetramethyl-3-(methylsulfanyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylate, 
 9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 2-hydroxy-2-{9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-trien-4-yl}acetic acid, 
 9,9,11,11-tetramethyl-10-oxa-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 2-{9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}-2-hydroxyacetic acid, 
 1-{10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-trien-4-yl}-3-methanesulfonylurea, 
 10-tert-butyl-3-(4-methoxyphenyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10,10-dimethyl-7-thia-2,5-diazatetracyclo[6.4.0.0 2,6 0.0 9,11 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 N-methanesulfonyl-9,9,11,11-tetramethyl-10-oxa-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 N-methanesulfonyl-10,10-dimethyl-7-thia-2,5-diazatetracyclo[6.4.0.0 2,6 0.0 9,1 ]dodeca-1(8),3,5-triene-4-carboxamide, 
 10-tert-butyl-3-acetamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-methanesulfonamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,12-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-Iodo-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8), 3,5-triene-4-carboxylic acid, 
 10-tert-butyl-4-(1H-1,2,3,4-tetrazol-5-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene 
 10-[(trifluoromethyl)sulfanyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(methylsulfanyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,10-dichloro-3-[(dimethylamino)methyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,11-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-[(dimethylamino)methyl]-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-chloro-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-(benzyloxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,10-difluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-3-[(dimethylamino)methyl]-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(cyclopentyloxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 11-chloro-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-chloro-9-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-N-methanesulfonyl-10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxamide, 
 3-methanesulfonamido-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-bromo-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-(Pyrrolidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 2-{9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}-2-hydroxyacetic acid, 
 3-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 3-ethynyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-chloro-11-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-methanesulfonamido-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-(Azetidin-3-yl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 (4S)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, (configuration arbitrarily assigned) 
 (4R)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, (configuration arbitrarily assigned) 
 9-chloro-10-fluoro-3-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-acetyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-bromo-9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9,10-dichloro-12-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-tert-butyl-3-(morpholin-4-ylmethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-bromo-9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-tert-butyl-3-[(2-oxopiperidin-1-yl)methyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3,9,9,11,11-Pentamethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(morpholin-4-ylmethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-(2-methoxyphenyl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-(pyrrolidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-fluoro-4-(2-methylpropyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-fluoro-4-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 10-tert-butyl-3-{[(2-methoxyethyl)(methyl)amino]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-cyclopropyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-bromo-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-(4-methoxyphenyl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-(acetamidomethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-(hydroxymethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-{[methoxy(methyl)amino]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-cyclopropyl-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-4-(cyclopentylmethyl)-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-(morpholin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,10-dichloro-11-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 4-benzyl-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-fluoro-4-(hydroxymethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-10-fluoro-N-methanesulfonyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxamide, 
 9-chloro-10-(piperidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-(3,3-difluoroazetidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 3-(3,3-difluoroazetidin-1-yl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-{1-[(tert-butoxy)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(pyrrolidin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-({4-[(tert-butoxy)carbonyl]piperazin-1-yl}methyl)-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-{[4-(2-methoxyethyl)piperazin-1-yl]methyl}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-[(4-methylpiperazin-1-yl)methyl]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-3-(piperazin-1-ylmethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-[(4-acetylpiperazin-1-yl)methyl]-10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-(4-methylpiperazin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-{[2-(pyrrolidin-1-yl)ethyl]amino}-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 N-(benzenesulfonyl)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxamide, 
 (4R)-9-chloro-10-fluoro-4-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 (4S)-9-chloro-10-fluoro-4-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 3-(dimethylamino)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-(azetidin-3-yl)-9-chloro-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(piperazin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 3-(4-acetylpiperazin-1-yl)-9,9,11,11-tetramethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,10-dichloro-11-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxylic acid, 
 9-chloro-N-[(dimethyl-1,2-oxazol-4-yl)sulfonyl]-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8)3,5,9-tetraene-4-carboxamide, 
 9,9,11,11-tetramethyl-3-(prop-1-en-2-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(4-methylpiperazin-1-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-chloro-9-fluoro-11-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-(1-methylazetidin-3-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-3-cyclopropyl-10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9,9,11,11-tetramethyl-3-(methylsulfanyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 9-chloro-10-fluoro-3-(1-methanesulfonylazetidin-3-yl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, and 
 9-chloro-10-fluoro-N-methanesulfonyl-4-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),5,9,11-tetraene-4-carboxamide, 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
       14. A pharmaceutical composition comprising a compound of formula (I) 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein 
         b is an integer of from 0 to 4; 
         ring A is a 5- to 7-membered, aromatic or non-aromatic carbocycle or heterocycle; 
         Q is a direct bond, CH 2 , CH(OH) or NH; 
         R 1  is R 4 C(O), cyano, or tetrazolyl; 
         R 4  is H, R 5 O, or NHR 6 ; 
         R 5  is H or C1-C6 alkyl; 
         R 6  is cyano, C1-C6 alkyl, or R 7 S(O) 2 ; 
         R 7  is C1-C6 alkyl, C3-C6 cycloalkyl, R 8 (CH 2 ) y , or 5- or 6-membered aryl or heteroaryl, 
         said aryl or heteroaryl optionally being substituted by one or more moieties independently selected from C1-C6 alkyl, 
         R 8  is R 9 O, R 10 R 11 N or R 12 OC(O), 
         R 9  is H or C1-C6 alkyl; 
         R 10  and R 11  are independently selected from H and C1-C6 alkyl, or R 10  and R 11 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; 
         R 12  is H or C1-C6 alkyl; 
         y is an integer from 1 to 4; 
         R 2  is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, halogen, cyano, R 13 R 14 N(CH 2 ) d , R 15 O(CH 2 ) e , R 16 S(CH 2 ) f , R 17 C(O)(CH 2 ) g , 
       
       
         
           
           
               
               
           
         
       
       or
 phenyl, optionally substituted by R 19 O(CH 2 ) i , 
 R 13  is H, C1-C6 alkyl, R 20 C(O), R 21 S(O) 2 , R 22 O(CH 2 ) j , R 23 R 24 N(CH 2 ) k , or benzyl, and 
 R 14  is H or C1-C6 alkyl; or 
 R 13  and R 14 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring, said ring optionally being substituted by one or more substituents independently selected from oxo, halogen, C1-C6 alkyl, R 25 C(O), R 26 OC(O), and 
 R 27 O(CH 2 ) m , 
 R 15  is H, C1-C6 alkyl or R 28 C(O); 
 R 16  and R 17  are selected from H and C1-C6 alkyl; 
 R 18  is H, C1-C6 alkyl, R 29 OC(O)(CH 2 ) n , or R 30 S(O) 2 (CH 2 ) p , 
 R 19 , R 20 , R 21 , R 22 , R 25 , R 26 , R 27 , R 28 , R 29  and R 30  are selected from H and C1-C6 alkyl; 
 R 23  and R 24  are independently selected from H and C1-C6 alkyl; or R 23  and R 24 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; 
 ring B is 4- to 6-membered, and saturated or unsaturated; 
 m, n, and p are integers of from 0 to 4; 
 R′ 1  and R′ 2  together form a bond; or 
 R′ 1  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) q , or R 31 O(CH 2 ) r ; and R′2 is H; 
 R 31  is H or C1-C6 alkyl; 
 q and r are integers of from 0 to 4; and 
 each R 3  is independently selected from C1-C6 alkyl, C3-C6 carbocyclyl, halogen, oxo, R 32 O, R 33 S, and R 34 R 35 N; 
 R 32  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) s , or R 36 R 37 N(CH 2 ) t ; 
 R 33  is H or C1-C6 alkyl; 
 R 34  and R 35  are independently selected from H and C1-C6 alkyl; or R 34  and R 35 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring optionally substituted by one or more halogen; 
 R 36  and R 37  are independently selected from H and C1-C6 alkyl, or R 36  and R 37 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; optionally substituted by one or more halogen; 
 s and t are integers of from 0 to 4; 
 and 
 two R 3  attached to adjacent atoms of ring A, together with the atoms to which they are attached, may form a 3- to 6 membered ring, said ring being optionally substituted by one or more C1-C6 alkyl; 
 any alkyl, alkenyl and cycloalkyl is optionally substituted by one or more F, and optionally a pharmaceutically acceptable excipient; 
 provided that the compound is not 
 12-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.4.0.0 2 ′ 6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 2-{7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{11-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 ethyl 10-ethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 methyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 propyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 isopropyl 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene-13-carboxylic acid, 
 2-{16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-13-yl}acetic acid, 
 2-{10-trifluoromethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, or 
 2-{12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid. 
 
     
     
       15. A pharmaceutical composition comprising a compound according to  claim 1 , or a compound selected from
 9,10-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(trifluoromethoxy)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 9-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid 
 10,11-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,12-dichloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.4.0.0 2 , 6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 10-tert-butyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5-triene-4-carboxylic acid, 
 ethyl 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 ethyl 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, and 
 ethyl 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylate, 
 or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable excipient. 
 
     
     
       16. A method of alleviating at least one symptom of a disorder selected from cancer, an inflammatory disorder, an autoimmunity disorder and a neurodegenerative disorder by administering, to a mammal in need thereof, a compound of formula (I) 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein 
         b is an integer of from 0 to 4; 
         ring A is a 5- to 7-membered, aromatic or non-aromatic carbocycle or heterocycle; 
         Q is a direct bond, CH 2 , CH(OH) or NH; 
         R 1  is R 4 C(O), cyano, or tetrazolyl; 
         R 4  is H, R 5 O, or NHR 6 ; 
         R 5  is H or C1-C6 alkyl; 
         R 6  is H, cyano, C1-C6 alkyl, or R 7 S(O) 2 ; 
         R 7  is C1-C6 alkyl, C3-C6 cycloalkyl, R 8 (CH 2 ) y , or 5- or 6-membered aryl or heteroaryl, said aryl or heteroaryl optionally being substituted by one or more moieties independently selected from C1-C6 alkyl, 
         R 8  is R 9 O, R 10 R 11 N or R 12 OC(O), 
         R 9  is H or C1-C6 alkyl; 
         R 10  and R 11  are independently selected from H and C1-C6 alkyl, or R 10  and R 11 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; 
         R 12  is H or C1-C6 alkyl; 
         y is an integer from 1 to 4; 
         R 2  is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, halogen, cyano, R 13 R 14 N(CH 2 ) d , R 15 O(CH 2 ) e , R 16 S(CH 2 ) f , R 17 C(O)(CH 2 ) g , 
       
       
         
           
           
               
               
           
         
       
       or
 phenyl, optionally substituted by R 19 O(CH 2 ) i ; 
 R 13  is H, C1-C6 alkyl, R 20 C(O), R 21 S(O) 2 , R 22 O(CH 2 ) j , R 23 R 24 N(CH 2 ) k , or benzyl, and R 14  is H or C1-C6 alkyl; or 
 R 13  and R 14 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring, said ring optionally being substituted by one or more substituents independently selected from oxo, halogen, C1-C6 alkyl, R 25 C(O), R 26 OC(O), and R 27 O(CH 2 ) m , 
 R 15  is H, C1-C6 alkyl or R 28 C(O); 
 R 16  and R 17  are selected from H and C1-C6 alkyl; 
 R 18  is H, C1-C6 alkyl, R 29 OC(O)(CH 2 ) n , or R 30 S(O) 2 (CH 2 ) p , 
 R 19 , R 20 , R 21 , R 22 , R 25 , R 26 , R 27 , R 28 , R 29  and R 30  are selected from H and C1-C6 alkyl; 
 R 23  and R 24  are independently selected from H and C1-C6 alkyl; or R 23  and R 24 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; 
 ring B is 4- to 6-membered, and saturated or unsaturated; 
 d, e, f, g, h, i, j, k, m, n, and p are integers of from 0 to 4; 
 R′ 1  and R′ 2  together form a bond; or 
 R′ 1  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) q , or R 31 O(CH 2 ) r ; and R′ 2  is H; 
 R 31  is H or C1-C6 alkyl; 
 q and r are integers of from 0 to 4; and 
 each R 3  is independently selected from C1-C6 alkyl, C3-C6 carbocyclyl, halogen, oxo, R 32 O, R 33 S, and R 34 R 35 N; 
 R 32  is H, C1-C6 alkyl, C3-C6 carbocyclyl-(CH 2 ) s , or R 36 R 37 N(CH 2 ) t ; 
 R 33  is H or C1-C6 alkyl; 
 R 34  and R 35  are independently selected from H and C1-C6 alkyl; or R 34  and R 35 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring optionally substituted by one or more halogen; 
 R 36  and R 37  are independently selected from H and C1-C6 alkyl, or R 36  and R 37 , together with the nitrogen atom to which they are both attached, form a 4- to 6-membered ring; optionally substituted by one or more halogen; 
 s and t are integers of from 0 to 4; 
 and 
 two R 3  attached to adjacent atoms of ring A, together with the atoms to which they are attached, may form a 3- to 6 membered ring, said ring being optionally substituted by one or more C1-C6 alkyl; 
 any alkyl, alkenyl and cycloalkyl is optionally substituted by one or more F; 
 provided that the compound is not 
 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 2-{7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{11-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene-13-carboxylic acid, 
 2-{16-thia-11,14-diazatetracyclo[8.6.0.0 2,7 0.0 11,15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-13-yl}acetic acid, 
 2-{10-trifluoromethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, 
 2-{10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid, or 
 2-{12-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaen-4-yl}acetic acid. 
 
     
     
       17. The method according to  claim 16 , wherein the disorder is cancer, an autoimmunity disorder or a neurodegenerative disorder, and wherein the compound is as defined in  claim 16  or is selected from
 10-chloro-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-bromo-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, and 
 10-(trifluoromethyl)-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
       18. The method according to  claim 17 , wherein the disorder is cancer or a neurodegenerative disorder, and wherein the compound is as defined in  claim 17  or is a compound selected from
 10,11-dimethyl-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 10-methoxy-7-thia-2,5-diazatricyclo[6.4.0.0 2,6 ]dodeca-1(8),3,5,9,11-pentaene-4-carboxylic acid, 
 or a pharmaceutically acceptable salt thereof.
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