Xylose derivatives and process for preparation thereof

Abstract

Disclosure of the present invention relates to a method for synthesis of a xylose derivative, which comprises protecting a xylose with a protective group, followed by incorporating to a halogen atom as a leaving group; removing the protective groups and using water-soluble ligands to carry out a Suzuki cross-couplings reaction with a palladium catalyst in a water solution. Ten new xylose derivatives as obtained by the method are also provided.

I claim: 
     
       1. A xylose derivative having the general formula I: 
       
         
           
           
               
               
           
         
         wherein the m for (R)m is an integer from 1 to 4; R is CH 3 , OCH 3 , or a halogen atom. 
       
     
     
       2. The xylose derivative of  claim 1 , which is one selected from the group consisting of the following: 
       
         
           
           
               
               
           
         
         2-(4′-chlorobiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 1); 
       
       
         
           
           
               
               
           
         
         2-(4′-methylbiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 2); 
       
       
         
           
           
               
               
           
         
         2-(4′-methoxybiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 3); 
       
       
         
           
           
               
               
           
         
         2-(2′-methylbiphenyl-4-yloxy)tetrahydro-2H-pyran-3,4,5-triol (Compound 4); 
       
       
         
           
           
               
               
           
         
         2-(2′-chlorobiphenyl-4-yloxy)tetrahydro-2H-pyran-3,4,5-triol (Compound 5); 
       
       
         
           
           
               
               
           
         
         2-(2′-methoxybiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 6); 
       
       
         
           
           
               
               
           
         
         2-(3′-methylbiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 7); 
       
       
         
           
           
               
               
           
         
         2-(3′-methoxybiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 8); 
       
       
         
           
           
               
               
           
         
         2-(3′-chlorobiphenyl-4-yloxy) tetrahydro-2H-pyran-3,4,5-triol (Compound 9); and 
       
       
         
           
           
               
               
           
         
         2-(3′, 5′-dimethylbiphenyl-4-yloxy)tetrahydro-2H-pyran-3,4,5-triol (Compound 10).