US10385088B2ActiveUtilityPatentIndex 97
Polynucleotide molecules and uses thereof
Est. expiryOct 2, 2033(~7.3 yrs left)· nominal 20-yr term from priority
C07H 19/167C07H 19/067C07K 14/565C07H 21/02C07K 14/525C07H 19/10C07H 19/20C07K 14/535
97
PatentIndex Score
66
Cited by
323
References
12
Claims
Abstract
The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.
Claims
exact text as granted — not AI-modifiedThe invention claimed is:
1. An mRNA 30 to 5000 nucleotides in length encoding a polypeptide, the mRNA comprising at least one backbone moiety having the structure:
wherein B is a nucleobase;
or a salt thereof.
2. The mRNA of claim 1 , wherein B has the structure:
3. The mRNA of claim 1 , wherein B has the structure:
4. The mRNA of claim 1 , wherein B has the structure:
5. The mRNA of claim 1 , wherein B has the structure:
6. The mRNA of claim 1 , wherein B has the structure:
7. The mRNA of claim 1 , wherein B has the structure:
8. The mRNA of claim 1 , wherein B has the structure:
9. The mRNA of claim 1 , wherein B has the structure:
10. The mRNA of claim 1 , further comprising:
(a) a 5′ untranslated region;
(b) a 3′ untranslated region; and
(c) a 5′ cap structure.
11. The mRNA of claim 10 , wherein the 5′ cap structure has the structure:
or a salt thereof.
12. The mRNA of claim 10 , further comprising a poly-A tail 100 to 250 nucleotides in length at the 3′-terminus of the 3′-untranslated region.Cited by (0)
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