US10450297B2ActiveUtilityA1

Sulfonyl amide derivatives for the treatment of abnormal cell growth

90
Assignee: PFIZERPriority: Apr 18, 2007Filed: Apr 5, 2018Granted: Oct 22, 2019
Est. expiryApr 18, 2027(~0.7 yrs left)· nominal 20-yr term from priority
Inventors:Michael Joseph LuzzioKevin Daniel Freeman-CookSamit Kumar BhattacharyaMatthew Merrill HaywardCatherine Angela HulfordChristopher Lowell AutryXumiao ZhaoJun XiaoKendra Louise Nelson
A61P 43/00A61P 35/04A61P 35/02A61P 35/00A61P 29/00A61P 27/02A61P 25/00A61P 19/10A61P 19/08A61P 19/02A61P 17/06A61P 13/08C07D 241/20C07D 403/12C07D 401/12C07D 239/48C07D 417/14C07D 413/14C07D 401/14C07D 417/12C07D 475/00C07D 405/14A61K 31/506A61K 31/505
90
PatentIndex Score
5
Cited by
82
References
14
Claims

Abstract

The present invention relates to a compound of the formula I wherein R 1 to R 6 , A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A method of making a compound of Formula (1), the method comprising: 
       
         
           
           
               
               
           
         
         reacting a compound of Formula (C3): 
       
       
         
           
           
               
               
           
         
         with a compound of Formula (B5): 
       
       
         
           
           
               
               
           
         
         thereby providing the compound of Formula (1). 
       
     
     
       2. The method of  claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base. 
     
     
       3. The method of  claim 2 , wherein the base is diethylamine (DIEA). 
     
     
       4. The method of  claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours. 
     
     
       5. The method of  claim 1 , wherein the reaction is performed in the presence of a solvent. 
     
     
       6. The method of  claim 5 , wherein the solvent is 1,2-dichloroethane (DCE):t-BuOH. 
     
     
       7. The method of  claim 6 , wherein the 1,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol. 
     
     
       8. The method of  claim 1 , wherein the temperature is 80° C. 
     
     
       9. The method of  claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature. 
     
     
       10. The method of  claim 9 , wherein the ambient temperature is 25° C. 
     
     
       11. The method of  claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc. 
     
     
       12. The method of  claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water. 
     
     
       13. The method of  claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO 4 . 
     
     
       14. The method of  claim 9 , wherein isolating the compound of Formula (1) comprises filtration.

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