US10471042B2ActiveUtilityA1

Composition containing artesunate

77
Assignee: ZHAO MINGPriority: Jan 15, 2016Filed: Jan 13, 2017Granted: Nov 12, 2019
Est. expiryJan 15, 2036(~9.5 yrs left)· nominal 20-yr term from priority
Inventors:Ming ZhaoLi Zhou
A61P 3/10A61P 43/00A61P 41/00A61P 37/08A61P 9/10A61P 9/04A61P 9/00A61P 33/12A61P 33/10A61P 35/02A61P 35/00A61P 33/06A61P 33/02A61P 33/00A61P 31/12A61P 31/10A61P 31/04A61P 31/00A61P 29/00A61P 25/00A61P 19/04A61P 19/02A61P 19/00A61P 17/02A61P 17/00A61P 15/00A61P 13/12A61P 13/10A61P 13/02A61P 11/06A61P 11/00A61P 1/18A61P 1/16A61P 1/02A61P 1/00A61K 47/26A61K 47/24A61K 31/133A61K 47/12A61K 9/08A61K 9/0019A61K 31/357A61K 45/06A61K 47/18A61K 47/22Y02A50/411Y02A50/423Y02A50/30A61K 47/183A61K 47/02
77
PatentIndex Score
1
Cited by
30
References
18
Claims

Abstract

The present disclosure provides a composition of artesunate, a process of preparing the same, and a method of treatment.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A composition comprising artesunate dissolved in a tris(hydroxymethyl)aminomethane buffer solution; wherein the buffer solution comprises a buffering agent selected from acetic acid, citric acid, succinic acid, phosphoric acid, glycine, hydrochloric acid, and sulfuric acid; and wherein the concentration of tris(hydroxymethyl)aminomethane is in the range of about 0.3 to about 0.35 mol/L. 
     
     
       2. The composition of  claim 1 , wherein the composition has a pH in the range of about 7.2 to about 8.2. 
     
     
       3. The composition of  claim 1 , wherein the mole ratio of artesunate and the tris(hydroxymethyl)aminomethane is in the range of about 1:2 to about 1:15. 
     
     
       4. The composition of  claim 1 , wherein the concentration of tris(hydroxymethyl)aminomethane is about 0.3 mol/L. 
     
     
       5. The composition of  claim 1 , wherein the buffering agent is acetic acid. 
     
     
       6. The composition of  claim 1 , wherein the buffering agent is phosphoric acid. 
     
     
       7. The composition of  claim 1 , wherein the composition is administered topically. 
     
     
       8. A composition for parenteral administration of artesunate comprising artesunate dissolved in a tris(hydroxymethyl)aminomethane buffer solution; wherein the buffer solution comprises a buffering agent selected from acetic acid, citric acid, succinic acid, phosphoric acid, glycine, hydrochloric acid; and wherein the concentration of tris(hydroxymethyl)aminomethane is in the range of about 0.3 to about 0.35 mol/L; and wherein the concentration of artesunate is in a range of about 10 mg/mL to 20 mg/mL. 
     
     
       9. The composition of  claim 8 , wherein the concentration of artesunate is about 10 mg/mL. 
     
     
       10. A formulation of artesunate comprising artesunate powder dissolved in a tris(hydroxymethyl)aminomethane buffer solution, wherein the buffer solution comprises a buffering agent selected from acetic acid, phosphoric acid, and hydrochloric acid; and wherein the concentration of tris(hydroxymethyl)aminomethane is in the range of about 0.3 to about 0.35 mol/L. 
     
     
       11. The formulation of  claim 10 , wherein the buffering agent is acetic acid. 
     
     
       12. The formulation of  claim 10 , wherein the buffering agent is phosphoric acid. 
     
     
       13. The formulation of  claim 10 , wherein the buffering agent is hydrochloric acid. 
     
     
       14. The formulation of  claim 10 , wherein the pH of the formulation is in the range of about 7.2 to about 8.2. 
     
     
       15. The formulation of  claim 10 , wherein the concentration of artesunate is about 10 mg/mL; and the pH is about 7.5. 
     
     
       16. The composition of  claim 1 , wherein the concentration of artesunate is in the range of about 0.1% to about 2% by weight/volume. 
     
     
       17. The composition of  claim 8 , wherein the concentration of artesunate is in the range of about 0.1% to about 2% by weight/volume. 
     
     
       18. The formulation of  claim 10 , wherein the concentration of artesunate is in the range of about 0.1% to about 2% by weight/volume.

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