P
US10532124B2ActiveUtilityPatentIndex 49

Water soluble farnesol analogs and their use

Assignee: KIMBERLY CLARK COPriority: Dec 27, 2012Filed: Dec 27, 2012Granted: Jan 14, 2020
Est. expiryDec 27, 2032(~6.5 yrs left)· nominal 20-yr term from priority
Inventors:KOENIG DAVID WILLIAMFOEGEN MARY KAYCUNNINGHAM COREY THOMASHE AIMINHUANG YANG
C07C 69/007C07C 33/02A61L 15/44A61L 15/20A61L 15/62C07C 43/15C07C 43/178A61L 2300/404A61L 2300/22C07C 69/67C07C 69/40C07H 3/02C07C 43/188C07C 43/1785A61L 2300/232A61F 13/8405C07C 69/73
49
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Cited by
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References
17
Claims

Abstract

Farnesol analogs, along with their related products (e.g., treatment compositions, wipes, absorbent articles, etc.) and their methods of formation, are provided. The farnesol analog includes a hydrophilic end group (e.g., a hydroxyl end group or a carboxylic acid end group) attached to farnesol via a covalent linkage (e.g., an ester group or an ether group).

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A farnesol analog comprising a hydrophilic end group attached to farnesol via a covalent linkage, wherein the hydrophilic end group defines a hydroxyl end group, and wherein the covalent linkage comprises an ester group or an ether group, wherein the farnesol analog comprises one of the structures: 
       
         
           
           
               
               
           
         
         where n is an integer from 1 to 8; m is an integer from 1 to 8; and p is an integer from 1 to 100. 
       
     
     
       2. The farnesol analog as in  claim 1 , wherein the covalent linkage comprises an ester group. 
     
     
       3. The farnesol analog as in  claim 1 , wherein n is 2, 3, or 4. 
     
     
       4. The farnesol analog as in  claim 3 , wherein the hydrophilic end group comprises an ester group. 
     
     
       5. The farnesol analog as in  claim 1 , wherein n is 2, 3, or 4; and wherein m is 2, 3, or 4. 
     
     
       6. The farnesol analog as in  claim 1 , wherein the covalent linkage comprises an ether group, and wherein the hydrophilic end group defines a hydroxyl end group. 
     
     
       7. The farnesol analog as in  claim 1 , wherein the farnesol analog has a solubility in water that is 10 grams per 100 grams of water or greater. 
     
     
       8. A web comprising a plurality of fibers, wherein the web is coated with a treatment composition, the treatment composition comprising a farnesol analog according to  claim 1 . 
     
     
       9. An absorbent article comprising:
 a liquid impermeable outer cover; 
 a liquid permeable bodyside liner, wherein the bodyside liner comprises the web according to  claim 8 ; and 
 an absorbent body disposed between the outer cover and bodyside liner. 
 
     
     
       10. A method of forming a farnesol analog that is soluble in water from a farnesol molecule having a hydroxyl group, the method comprising:
 covalently attaching a hydrophilic end group to the farnesol molecule via reaction with its hydroxyl group to form a covalent linkage, wherein the hydrophilic end group defines a hydroxyl end group, and wherein the covalent linkage comprises an ester group or an ether group, wherein the farnesol analog comprises one of the structures: 
 
       
         
           
           
               
               
           
         
         where n is an integer from 1 to about 8; m is an integer from 1 to 8; and p is an integer from 1 to 100. 
       
     
     
       11. The method as in  claim 10 , wherein the covalent linkage comprises an ester group formed via an esterification reaction between the hydroxyl group of the farnesol molecule and a carboxylic acid functional molecule. 
     
     
       12. The method as in  claim 11 , further comprising:
 reacting the carboxylic acid end group with a glycol via a second esterification reaction to form a farnesol analog having a hydroxyl group covalently attached via two ester linkages. 
 
     
     
       13. The method as in  claim 12 , wherein the glycol is selected from the group consisting of ethylene glycol, propylene glycol, and butane-1,4-diol. 
     
     
       14. The method as in  claim 10 , wherein the covalent linkage comprises an ether group formed by reacting farnesol with an alcohol via a dehydration reaction to form the ether group. 
     
     
       15. The method as in  claim 14 , wherein the alcohol is a glycol selected from the group consisting of ethylene glycol, propylene glycol, and butane-1,4-diol. 
     
     
       16. The method as in  claim 14 , wherein the hydrophilic end group comprises a sugar. 
     
     
       17. A wipe comprising the web according to  claim 8 .

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