BPO wash gel composition

Abstract

A topical dermatological/pharmaceutical composition is described that includes BPO wherein the composition is a wash composition with desirable tolerance, stability and foaming properties. The composition can include: a) benzoyl peroxide (BPO); b) at least one mild surfactant selected from anionic and/or non-ionic surfactant classes; c) zinc gluconate; d) dipotassium glycyrrhizate; and e) at least one gelling agent. The composition is preferably in the form of an aqueous gel or an aqueous-alcoholic gel. Also described, is the use of such a composition for the treatment of dermatological disorders, and in particular in the treatment of acne.

The invention claimed is: 
     
       1. A topical wash composition comprising:
 (a) benzoyl peroxide at a nonzero concentration of equal to or less than 5% w/w; 
 (b) at least one anionic and/or non-ionic surfactant selected from the group consisting of sodium lauroyl methyl isethionate, decyl glucoside, zinc coceth sulfate, sodium cocoyl isethionate, and C14-C16 α-olefinsulfonates; 
 (c) zinc gluconate; and 
 (d) dipotassium glycyrrhizate; 
 wherein at least 90% of the benzoyl peroxide in the composition remains in the composition after storage at 40° C. for one to two months. 
 
     
     
       2. The composition according to  claim 1 , wherein the composition is a foaming composition. 
     
     
       3. The composition according to  claim 1 , wherein the composition further comprises at least one gelling agent selected from the group consisting of gelling agents in the polyacrylamide family, “electrolyte-insensitive” carbomers, polysaccharides, cellulose derivatives, bentonite, magnesium aluminium silicates, neutralized polymeric sulfonic acid and mixtures thereof. 
     
     
       4. The composition according to  claim 1 , wherein the composition comprises between 1% w/w and 5% w/w of benzoyl peroxide. 
     
     
       5. The composition according to  claim 3 , wherein the gelling agent is a polysaccharide, a magnesium aluminium silicate or a mixture thereof. 
     
     
       6. The composition according to  claim 5 , wherein the gelling agent is a xanthan gum, a magnesium aluminium silicate or a mixture thereof. 
     
     
       7. The composition according to  claim 1 , wherein the composition further comprises a wetting agent. 
     
     
       8. The composition according to  claim 7 , wherein the wetting agent is a poloxamer and/or a glycol. 
     
     
       9. The composition according to  claim 7 , wherein the wetting agent is propylene glycol, Poloxamer 124, or a mixture thereof. 
     
     
       10. The composition according to  claim 7 , wherein the wetting agent is at a concentration between 1% to 7% by weight with regards to the total composition weight. 
     
     
       11. The composition according to  claim 1 , wherein benzoyl peroxide is in dispersed form. 
     
     
       12. The composition according to  claim 1 , wherein the composition comprises between 2.5% and 3.5% of benzoyl peroxide expressed by weight of active ingredient relative to the total weight of the composition. 
     
     
       13. The composition according to  claim 1 , wherein the concentration of zinc gluconate expressed by weight relative to the total weight of the composition is between 0.15% and 0.3%. 
     
     
       14. The composition according to  claim 1 , wherein dipotassium glycyrrhizate is present at a concentration expressed by weight relative to the total weight of the composition between 0.15% and 0.3%. 
     
     
       15. A method of improving, or inhibiting a dermatological condition linked to acne treatment, the method comprising administering an effective amount of the composition according to  claim 1  to an individual subject in need thereof. 
     
     
       16. A method of treating acne, comprising administering to a subject in need thereof an effective amount of the composition according to  claim 1 . 
     
     
       17. The method as defined in  claim 16 , wherein the acne is common acne. 
     
     
       18. The composition according to  claim 13 , wherein the concentration of the zinc gluconate is between 0.2% and 0.3% by weight, relative to the total weight of the composition. 
     
     
       19. The composition according to  claim 14 , wherein the concentration of the dipotassium glycyrrhizate is between 0.25% and 0.3% by weight, relative to the total weight of the composition. 
     
     
       20. The composition of  claim 1 , wherein the anionic and/or non-ionic surfactant is present at a concentration of between 0.5 and 5% by weight, relative to the total weight of the composition. 
     
     
       21. The composition of  claim 1 , wherein the dipotassium glycyrrhizate is present at a concentration of between 0.1 to 1% by weight, relative to the total weight of the composition. 
     
     
       22. The composition of  claim 1 , wherein the zinc gluconate is present at a concentration of between 0.1 and 1% by weight, relative to the total weight of the composition. 
     
     
       23. The composition of  claim 3 , wherein the gelling agent is present at a concentration of between 0.15 and 7% by weight, relative to the total weight of the composition.