Autophagy activation-induced compound for improving skin inflammation for aging

Abstract

Provided are a novel autophagy activation-inducing compound or salt thereof, and a use thereof, and particularly, a medicinal composition for treatment and prevention of neurodegenerative diseases, type II diabetes, or atopy or psoriasis dermatitis, a cosmetic composition for alleviation of aging or atopy or psoriasis dermatitis, and a food composition, including the compound capable of inducing autophagy activation or a pharmaceutically acceptable salt thereof.

The invention claimed is: 
     
       1. An autophagy activation-inducing compound represented by the following Chemical Formula 1: 
       
         
           
           
               
               
           
         
       
       wherein
 R is hydrogen or —X—R 1 ; X is a single bond or —CO—; and R 1  is C1-C20 substituted or unsubstituted alkyl, 
 or pharmaceutically acceptable salt thereof. 
 
     
     
       2. The autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 , wherein it is an autophagy activation-inducing compound represented by the following Chemical Formula 2: 
       
         
           
           
               
               
           
         
       
       wherein
 R′ is hydrogen or —X—R 2 ; X is a single bond or —CO—; and R 2  is C1-C20 substituted or unsubstituted alkyl. 
 
     
     
       3. The autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 , wherein X is —CO—, and R 2  is C1-C20 substituted or unsubstituted alkyl. 
     
     
       4. A medicinal composition for treatment and prevention of atopy or psoriasis skin diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 . 
     
     
       5. A medicinal composition for treatment and prevention of type II diabetes comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 . 
     
     
       6. A medicinal composition for treatment and prevention of neurodegenerative diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 . 
     
     
       7. The medicinal composition of  claim 6 , wherein the neurodegenerative diseases are Alzheimer's disease, Huntington's disease, or Parkinson's disease. 
     
     
       8. The medicinal composition of  claim 4 , wherein the compound
 or pharmaceutically acceptable salt thereof is comprised at 0.0001 to 10 wt. %. 
 
     
     
       9. The medicinal composition of  claim 4 , wherein it is used in a form of tablets, pills, capsules, granules, pulverized forms, powders, liquids, patches, coating agents or injections. 
     
     
       10. A cosmetic composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 . 
     
     
       11. The cosmetic composition of  claim 10 , wherein the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof is comprised at 0.0001 to 1 wt. %. 
     
     
       12. The cosmetic composition of  claim 10 , wherein the composition is at least one selected from the group consisting of a formulation of suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray. 
     
     
       13. A food composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 1 . 
     
     
       14. A medicinal composition for treatment and prevention of atopy or psoriasis skin diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 . 
     
     
       15. A medicinal composition for treatment and prevention of atopy or psoriasis skin diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 3 . 
     
     
       16. A medicinal composition for treatment and prevention of type II diabetes comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 . 
     
     
       17. A medicinal composition for treatment and prevention of type II diabetes comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 3 . 
     
     
       18. A medicinal composition for treatment and prevention of neurodegenerative diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 . 
     
     
       19. A medicinal composition for treatment and prevention of neurodegenerative diseases comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 3 . 
     
     
       20. A cosmetic composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 . 
     
     
       21. A cosmetic composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 3 . 
     
     
       22. A food composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 2 . 
     
     
       23. A food composition comprising the autophagy activation-inducing compound or pharmaceutically acceptable salt thereof of  claim 3 .