US10722491B2ActiveUtilityA1

Phenol compound and combination of same with a benzodiazepine fused to 1,4-dihydropyridine for treating diseases of the central nervous and vascular systems

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Assignee: UNIV LA HABANAPriority: May 4, 2016Filed: May 3, 2017Granted: Jul 28, 2020
Est. expiryMay 4, 2036(~9.8 yrs left)· nominal 20-yr term from priority
Inventors:Estael Ochoa RodríguezYamila Verdecia ReyesYanier Núñez FigueredoJeney Ramírez SánchezMaylin Wong GuerraLuis Arturo Fonseca FonsecaGilberto Lázaro Pardo AndreuClaudia Amanda Canaán-Haden NavarroAbel Mondelo RodriguezPedro Gilberto Bárzaga FernándezNicté González AlfonsoRené Delgado HernándezAlejandro Saúl Padrón Yaquis
C07D 319/06A61P 25/28A61P 25/16A61P 9/10A61K 31/357A61K 31/366A61K 9/2059A61K 47/44A61K 9/006A61K 9/14A61K 9/2018A61K 9/10A61K 9/0019A61K 47/06A61K 9/08A61K 31/5513A61K 2300/00
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PatentIndex Score
3
Cited by
7
References
15
Claims

Abstract

These pharmaceutical compositions exhibit GABAergic, antiglutamatergic, calcium channel modulating, mitoprotective, anti-oxidant, anti-inflammatory, and antiapoptotic action, usable in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. Pharmaceutical composition comprising the compound of formula I 
       
         
           
           
               
               
           
         
         and one or more pharmaceutically acceptable excipients. 
       
     
     
       2. The pharmaceutical composition according to  claim 1  further comprising the compound of formula II 
       
         
           
           
               
               
           
         
       
     
     
       3. The pharmaceutical composition according to  claim 2  wherein the compound of formula II is at least in the form of a racemate or in the form of its dextrorotatory or levorotatory enantiomer. 
     
     
       4. A method of treating diseases of the central and vascular nervous system comprising administering a pharmaceutical composition comprising an effective amount of the compound of formula I or a salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
       5. The method according to  claim 4 , wherein the pharmaceutical composition further comprises an effective amount of the compound of formula II or a salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
       6. The method according to  claim 4 , wherein the disease of the central and vascular nervous system is cerebral ischemia. 
     
     
       7. The method according to  claim 4 , wherein the disease of the central and vascular nervous system is Parkinson's disease. 
     
     
       8. The method according to  claim 4 , wherein the disease of the central and vascular nervous system is related to different types of dementias. 
     
     
       9. The method according to  claim 8 , wherein the dementia is Alzheimer's disease. 
     
     
       10. The method according to  claim 8 , wherein the dementia is vascular dementia. 
     
     
       11. The method according to  claim 5 , wherein the disease of the central and vascular nervous system is cerebral ischemia. 
     
     
       12. The method according to  claim 5 , wherein the disease of the central and vascular nervous system is Parkinson's disease. 
     
     
       13. The method according to  claim 5 , wherein the disease of the central and vascular nervous system is related to different types of dementias. 
     
     
       14. The method according to  claim 13 , wherein the dementia is Alzheimer's disease. 
     
     
       15. The method according to  claim 13 , wherein the dementia is vascular dementia.

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